Keywords: رسانه های بیرونی; Solid lipid-based drug delivery systems; Spray congealing; Controlled release; Biorelevant media; Dissolution rate; Microparticles;
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Keywords: رسانه های بیرونی; ÎCN; acetonitrile; API; active pharmaceutical ingredient; BCS; biopharmaceutics classification system; FeSSGF; fed state simulated gastric fluid; FeSSGFhf; fed state simulated gastric fluid prepared with high fat milk (5% w/v); FeSSGFsk; fed state simula
Keywords: رسانه های بیرونی; Functionalized mesoporous silica nanoparticle; Dissolution kinetics; Weibull model; Higuchi model; Simulated media; Biorelevant media;
Keywords: رسانه های بیرونی; Dissolution; Hypochlorhydria; Achlorhydria; Pioglitazone hydrochloride; Human aspirates; Weak bases; Biorelevant media;
Keywords: رسانه های بیرونی; Biorelevant media; Dissolution; Food effect; Itraconazole; Oral bioavailability; Self-micellizing solid dispersion; AUC0-2; area under the curve of dissolved itraconazole vs. time from 0 to 2Â h; AUC0-â; area under the curve of blood concentration v
Keywords: رسانه های بیرونی; Fed state; Gastric; Biorelevant media; Drug analysis; Dissolution; Bioavailability
Keywords: رسانه های بیرونی; RCM; Reaction crystallization method; PSD; Phase solubility diagram; FeSSIF; Fed state simulated intestinal fluid; [drug]eu; Drug concentration at the eutectic point; [coformer]eu; Coformer concentration at the eutectic point; Keu; Eutectic constant, Keu
Keywords: رسانه های بیرونی; Itraconazole; Cyclodextrin; Biorelevant media; Gastrointestinal transfer; Supersaturation; Precipitation;
Keywords: رسانه های بیرونی; Biorelevant media; DCS classes; Fasted state; Fed state; Classification; Decision tree;
The effect of 2-hydroxypropyl-β-cyclodextrin on the intestinal permeation through mucus
Keywords: رسانه های بیرونی; Cyclodextrin; Mucus; Artificial membrane insert system (AMI-system); Caco-2; Biorelevant media;
Considerations for the development of in vitro dissolution tests to reduce or replace preclinical oral absorption studies
Keywords: رسانه های بیرونی; Animal; Gastrointestinal physiology; Biorelevant media; In vitro; Dissolution testing;
Multiparticulate system combining taste masking and immediate release properties for the aversive compound praziquantel
Keywords: رسانه های بیرونی; Taste masking; Praziquantel; Extrusion; Solid lipid extrusion; Spray-drying; Biorelevant media;
Supersaturation of zafirlukast in fasted and fed state intestinal media with and without precipitation inhibitors
Keywords: رسانه های بیرونی; Preformulation; Food effects; Precipitation inhibitors; Amorphous; Biorelevant media; Bioavailability;
Matching phosphate and maleate buffer systems for dissolution of weak acids: Equivalence in terms of buffer capacity of bulk solution or surface pH?
Keywords: رسانه های بیرونی; Dissolution; Biorelevant media; Buffer capacity; Surface pH; Weak acids;
Advances in the design of fasted state simulating intestinal fluids: FaSSIF-V3
Keywords: رسانه های بیرونی; FaSSIF; Fasted state; Human intestinal fluid; Surface tension; Biorelevant media; Solubility; Bile salts; Lysolecithin;
Fasted-State Simulated Intestinal Fluid "FaSSIF-C", a Cholesterol Containing Intestinal Model Medium for In Vitro Drug Delivery Development
Keywords: رسانه های بیرونی; in vitro models; biorelevant media; drug solubility; lipids; micelle; light-scattering; DLS; SANS; FaSSIF; Caco-2 cells;
Predicting the oral pharmacokinetic profiles of multiple-unit (pellet) dosage forms using a modeling and simulation approach coupled with biorelevant dissolution testing: Case example diclofenac sodium
Keywords: رسانه های بیرونی; Diclofenac; Enteric coated pellet; Multiple units dosage form; Oral administration; Pharmacokinetics; Biorelevant media; Modeling and simulation
Biorelevant media for transport experiments in the Caco-2 model to evaluate drug absorption in the fasted and the fed state and their usefulness
Keywords: رسانه های بیرونی; Biorelevant media; Fasted state; Fed state; Permeability coefficient; Caco-2; Intestinal absorption;
Solubilization thermodynamics of ibuprofen in modified and classical FeSSIF biorelevant media
Keywords: رسانه های بیرونی; Ibuprofen; Biorelevant media; Solubilization thermodynamics; Sodium taurocholate; Phosphatidylcholine;
Understanding the in vivo performance of enteric coated tablets using an in vitro-in silico-in vivo approach: Case example diclofenac
Keywords: رسانه های بیرونی; Diclofenac; Monolithic enteric coated tablet; Oral administration; Pharmacokinetics; Biorelevant media; Modeling and simulation;
An in vitro–in silico–in vivo approach to predicting the oral pharmacokinetic profile of salts of weak acids: Case example dantrolene
Keywords: رسانه های بیرونی; Dantrolene; Precipitation; Oral administration; Pharmacokinetics; Biorelevant media
Dissolution media simulating the proximal canine gastrointestinal tract in the fasted state
Keywords: رسانه های بیرونی; Biorelevant media; Dogs; Bile salts; Phospholipids; Surface tension; Gastric fluid; Intestinal fluids; Dissolution tests; Solubility
Solubility and stability of dalcetrapib in vehicles and biological media
Keywords: رسانه های بیرونی; Dalcetrapib; Dalcetrapib solubility; Dalcetrapib stability; Biorelevant media; Biological media; Cholesteryl ester transfer protein (CETP)
Use of conventional surfactant media as surrogates for FaSSIF in simulating in vivo dissolution of BCS class II drugs
Keywords: رسانه های بیرونی; Biorelevant media; Compartmental absorption and transit (CAT) model; Fasted state simulated intestinal fluid (FaSSIF); Dissolution; In vitro–in vivo correlation (IVIVC); Pharmacokinetic simulation
Online monitoring of dissolution tests using dedicated potentiometric sensors in biorelevant media
Keywords: رسانه های بیرونی; Ion-Selective Electrode; Online monitoring; In situ dissolution; Biorelevant media; Online measurement; Electrodes
Biorelevant pKa (37 °C) predicted from the 2D structure of the molecule and its pKa at 25 °C
Keywords: رسانه های بیرونی; Ionization constant; pKa; Abraham's descriptors; Biorelevant media; Linear free energy relationships
Analysis of Nifedipine Absorption from Soft Gelatin Capsules Using PBPK Modeling and Biorelevant Dissolution Testing
Keywords: رسانه های بیرونی; absorption; biorelevant media; computational ADME; dissolution; nifedipine; PBPK modeling; pharmacokinetics; PK-Sim; precipitation; solubility;
Biorelevant Media Simulating Fed State Intestinal Fluids: Colloid Phase Characterization and Impact on Solubilization Capacity
Keywords: رسانه های بیرونی; solubilization; biorelevant media; Cryo-TEM; poorly soluble drug compounds;
The Developability Classification System: Application of Biopharmaceutics Concepts to Formulation Development
Keywords: رسانه های بیرونی; biopharmaceutics classification system (BCS); bioequivalence; oral absorption; developability; biorelevant media; solubility; permeability; dissolution rate;
Simulation of gastric lipolysis and prediction of felodipine release from a matrix tablet in the fed stomach
Keywords: رسانه های بیرونی; Intragastric release; Felodipine; Fed state; Biorelevant media; HPMC tablet
Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: Comparison with commercial preparations
Keywords: رسانه های بیرونی; Biorelevant media; Cogrinding; Dissolution rate enhancement; Fenofibrate; Jet milling; Micronization; Particle size reduction; Spray-drying
Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound
Keywords: رسانه های بیرونی; Biorelevant media; Solubility; Dissolution; Poorly soluble; In vivo–in vitro correlation (IVIVC)
High throughput UV method for the estimation of thermodynamic solubility and the determination of the solubility in biorelevant media
Keywords: رسانه های بیرونی; Solubility; Precipitation method; Biorelevant media; High-throughput measurements
A novel dissolution method relevant to intestinal release behaviour and its application in the evaluation of modified release mesalazine products
Keywords: رسانه های بیرونی; Mesalazine; 5-Aminosalicylic acid; Drug release; Dissolution; Simulation; Colon; Biorelevant media
In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media
Keywords: رسانه های بیرونی; In vivo in vitro correlations; Flow-through cell; Dissolution; Biorelevant media; Danazol;