In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH2) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and a
Keywords: PL-3994; Natriuretic peptide receptors; Atrial natriuretic peptide; Brain natriuretic peptide; Neutral endopeptidase sensitivity; BronchodilatorANP, atrial natriuretic peptide; ASM, airway smooth muscle; BNP, brain natriuretic peptide; BSA, bovine serum a