The positive is inside the negative: HER2-negative tumors can express the HER2 intracellular domain and present a HER2-positive phenotype
Keywords: HER 2; human epidermal growth factor receptor 2; FISH; fluorescent in situ hybridization; ECD; extracellular domain of HER2; ICD; intracellular domain of HER2; LC-MS; label-free nanoscale mass spectrometry; Human epithelial growth factor receptor 2 (HER