Keywords: CAPE، اسید کافئین فنیل استریل; ACE, angiotensin I-converting enzyme; BD, biodiesel; CAPE, caffeic acid phenethyl ester; CD, circular dichroism; DAG, diacylglycerol; DPPH, 2,2-diphenyl-1-picrylhydrazyl radical scavenging; DWGP, defatted wheat germ protein; EAE, enzyme assisted extractio
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Keywords: CAPE، اسید کافئین فنیل استریل; Antioxidant activity; CLA; Dairy; Flavonoids; Milk quality; Phenolic acidsPBP, propolis-based product; CAPE, caffeic acid phenethyl ester; DM, dry matter; TMR, total mixed ration; BW, body weight; NFC, non-fiber carbohydrates; SCC, somatic cell counts; FC
Turkish propolis supresses MCF-7 cell death induced by homocysteine
Keywords: CAPE، اسید کافئین فنیل استریل; DCFH-DA, 2′7′-dichlorodihydrofluorescin diacetate; CAPE, Caffeic Acid Phenethyl Ester; GSH-Px, Glutathione Peroxidase; Hcy, Homocysteine; H2O2, Hydrogen Peroxide; MDA, Malondialdehyde; MCF-7 cells, Michigan Cancer Foundation-7 Cells; μg/ml, Microgram/mili
Lead compound bearing caffeic scaffold induces EGFR suppression in solid tumor cancer cells
Keywords: CAPE، اسید کافئین فنیل استریل; CA, caffeic acid; CAPE, caffeic acid phenethyl ester; EGFR, epidermal growth factor receptor; RTK, receptor tyrosine kinase; TNBC, triple-negative breast cancerCaffeic acid derivatives; EGFR inhibitor; Triple-negative breast cancer; Non-small cell lung ca
Identification of a Novel Substance P–Neurokinin-1 Receptor MicroRNA-221-5p Inflammatory Network in Human Colonic Epithelial Cells
Keywords: CAPE، اسید کافئین فنیل استریل; Colitis; Inflammation; MicroRNA; Substance Pas, anti-sense; CAPE, caffeic acid phenethyl ester; COL2α1, collagen, type II, α 1; CXCL10, C-X-C motif chemokine 10; DSS, dextran sulfate sodium; IBD, inflammatory bowel disease; IL, interleukin; IL-6R, interle
Polyphenol-rich propolis extracts from China and Brazil exert anti-inflammatory effects by modulating ubiquitination of TRAF6 during the activation of NF-κB
Keywords: CAPE، اسید کافئین فنیل استریل; Propolis; Polyphenols; Anti-inflammatory; LPS; TRAF6; NF-κBBPPE, Brazilian propolis polyphenol-rich extracts; CAPE, caffeic acid phenethyl ester; COX-2, cyclooxygenase-2; CPPE, Chinese propolis polyphenol-rich extracts; DEX, dexamethasone; FRAP, ferric-re
N-phenethyl caffeamide and photodamage: Protecting skin by inhibiting type I procollagen degradation and stimulating collagen synthesis
Keywords: CAPE، اسید کافئین فنیل استریل; AP-1, activator protein-1; CAPE, caffeic acid phenethyl ester; DCFDA, 2′,7′-dichlorofluorescin diacetate; DMEM, Dulbecco’s modified Eagle’s medium; DMSO, dimethyl sulfoxide; DPPH, 1,1-diphenyl-2-picrylhydrazyl radical; ECM, extracellular matrix; K36, N-ph
Caffeic acid phenethyl ester, a 5-lipoxygenase enzyme inhibitor, alleviates diabetic atherosclerotic manifestations: Effect on vascular reactivity and stiffness
Keywords: CAPE، اسید کافئین فنیل استریل; AGEs, advanced glycation end products; ACh, acetyl choline; CAPE, caffeic acid phenethyl ester; BP, blood pressure; PE, phenylephrine; STZ, streptozotocin; TNF-α, tumor necrosis factor-α; HO-1, haem oxygenase-1; ELISA, enzyme-linked immunosorbent assay; A
Caffeic acid phenethyl ester prevents apoptotic cell death in the developing rat brain after pentylenetetrazole-induced status epilepticus
Keywords: CAPE، اسید کافئین فنیل استریل; CAPE, Caffeic acid phenethyl ester; SE, Status epilepticus; TUNEL, Terminal deoxynucleotidyl transferase-mediated dUTP nick end-labelingSeizure activity; Developing rat brain; Neuroprotection; Propolis; Natural product: honeybee propolis
Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pylori peptide deformylase activity
Keywords: CAPE، اسید کافئین فنیل استریل; CAPE, caffeic acid phenethyl ester; PDF, peptide deformylase; HpPDF, Helicobacter pylori PDF; PDIs, peptide deformylase inhibitors; FDH, formate dehydrogenase; f-MAS, N-formyl-Met-Ala-SerHelicobacter pylori; Peptide deformylase; Propolis; Phenolic compoun
Inhibition of arachidonic acid metabolism by the Andean crude drug Parastrephia lucida (Meyen) Cabrera
Keywords: CAPE، اسید کافئین فنیل استریل; AA, arachidonic acid; CAPE, caffeic acid phenethyl ester; COX, cyclooxygenase; 1,2dHGPC, 1,2-diheptanoilthio-glycerophosphocholine; DMSO, dimethyl sulfoxide; DTNB, 5,5′ dithiobis-2-nitrobenzoic acid; LTs, leukotrienes; LOX, lipoxygenase; NSAIDs, non-stero
Mechanism of acute lung injury due to phosgene exposition and its protection by cafeic acid phenethyl ester in the rat
Keywords: CAPE، اسید کافئین فنیل استریل; ALI, acute lung injury; CAPE, caffeic acid phenethyl ester; BALF, bronchoalveolar lavage fluidALI; Phosgene; Chloride gadolinium; CAPE; Inflammation; Oxidative stress
Grape seed proanthocyanidins inhibit migration potential of pancreatic cancer cells by promoting mesenchymal-to-epithelial transition and targeting NF-κB
Keywords: CAPE، اسید کافئین فنیل استریل; EMT, epithelial–mesenchymal transition; NF-κB, nuclear factor-kappaB; GSPs, grape seed proanthocyanidins; CAPE, caffeic acid phenethyl ester; MMP, matrix metalloproteinaseNF-κB; Epithelial-to-mesenchymal transition; Pancreatic cancer cells; Cancer cell mi
Caffeic acid phenethyl ester protects against the dopaminergic neuronal loss induced by 6-hydroxydopamine in rats
Keywords: CAPE، اسید کافئین فنیل استریل; AIF, apoptosis-inducing factor; ANOVA, analysis of variance; AP, Antero-Posterior; BSA, bovine serum albumin; CAPE, caffeic acid phenethyl ester; CPu, caudate putamen; CsA, cyclosporin A; DCFH-DA, dihydrodichlorofluorescein diacetate; DMSO, dimethyl sulfo
Regulation of thrombomodulin expression in prostate cancer cells
Keywords: CAPE، اسید کافئین فنیل استریل; Prostate cancer cells; Thrombomodulin; DNA methylation; Cell signalling5-aza-dC, 5-aza-2′-deoxycytidine; BSA, bovine serum albumin; CAPE, caffeic acid phenethyl ester; DMSO, dimethyl sulphoxide; FCS, foetal calf serum; GSK-3, glycogen synthase kinase-3β;
Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo–keto reductase 1B10
Keywords: CAPE، اسید کافئین فنیل استریل; AKR1B10; Aldose reductase; Caffeic acid phenethyl ester; Inhibitor; Selectivity; CancerAKR, Aldo–keto reductase; AKR1B1, Human aldose reductase; AKR1B10, A human member in the AKR1B subfamily of the AKR superfamily; CAPE, Caffeic acid phenethyl ester
4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling
Keywords: CAPE، اسید کافئین فنیل استریل; ABCC, ATP-binding cassette, subfamily C member; AKR1C, aldo-keto reductase family member; ARE, antioxidant-response element; t-BHQ, tert-butylhydroquinone; CAPE, caffeic acid phenethyl ester; DCF, dichlorofluorescein; DCFH-DA, 2′,7′-chlorofluorescein diac
Viral enzymes containing magnesium: Metal binding as a successful strategy in drug design
Keywords: CAPE، اسید کافئین فنیل استریل; 3-P, 3′-processing; CAPE, caffeic acid phenethyl ester; 5-CITEP, 1-(5-chloroindol-3-yl)-3-hydroxy-3-(2H-tetrazol-5-yl)-propenone; AIDS, acquired immunodeficiency syndrome; CCD, catalytic core domain; CTD, C-terminal domain; DKA, β-diketo acid; EIV, influe
Hyperoxia attenuates the inhibitory effect of nitric oxide donors on HIF prolyl-4-hydroxylase-2: Implication on discriminative effect of nitric oxide on HIF prolyl-4-hydroxylase-2 and collagen prolyl-4-hydroxylase
Keywords: CAPE، اسید کافئین فنیل استریل; NO, Nitric oxide; GSNO, S-nitrosoglutathione; SNAP, (±)-S-nitroso-N-acetylpenicillamine; HIF-1α, Hypoxia inducible factor-1 alpha; HPH, HIF prolyl-4-hydroxylase; VHL, von Hippel-Lindau; IVT, In vitro translated; CAPE, Caffeic acid phenethyl ester; P4Hs, P
Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurodegeneration
Keywords: CAPE، اسید کافئین فنیل استریل; MPTP; Parkinson's disease; mitochondria; CAPEAIF, apoptosis inducing factor; CAPE, caffeic acid phenethyl ester; CGN, cerebellar granule neurons; DA, dopamine; DAT, dopamine transporter; iNOS, inducible nitric oxide synthase; MAO, monoamine oxidase; MPTP,
Suppressive effects of methoxyflavonoids isolated from Kaempferia parviflora on inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells
Keywords: CAPE، اسید کافئین فنیل استریل; CAPE, caffeic acid phenethyl ester; DMEM, Dulbecco's modified Eagle's medium; eNOS, endothelial nitric oxide synthase; ERK, extracellular signal-regulated kinase; IFNγ, interferon-γ; IκB, inhibitor of κB; IKK, IκB kinase; iNOS, inducible nitric oxide synt
The metabolic bioactivation of caffeic acid phenethyl ester (CAPE) mediated by tyrosinase selectively inhibits glutathione S-transferase
Keywords: CAPE، اسید کافئین فنیل استریل; CAPE, caffeic acid phenethyl ester; CA, caffeic acid; 4-HA, 4-hydroxyanisole; MEM, Modified Eagle Medium Alpha; FBS, fetal bovine serum; PBS, phosphate buffered saline; MEM, Minimum Essential Medium; MTT, (3-(4,5-dimethylthiazolyl-2)-2,5-diphenyl tetrazol
Polyphenols as small molecular inhibitors of signaling cascades in carcinogenesis
Keywords: CAPE، اسید کافئین فنیل استریل; Carcinogenesis; Chemoprevention; Polyphenol; Signaling cascades5-DK, 5-Deoxykaempferol; 7,3′,4′-THIF, 7,3′,4′-Trihydroxyisoflavone; AhR, aryl hydrocarbon receptor; AP-1, activator protein 1; CAPE, caffeic acid phenethyl ester; CBP, CREB-binding protein; C
Effects of caffeic acid phenethyl ester on thioacetamide-induced hepatic encephalopathy in rats
Keywords: CAPE، اسید کافئین فنیل استریل; HE, Hepatic encephalopathy; CAPE, Caffeic acid phenethyl ester; ROS, Reactive oxygen species; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; CAT, Catalase; SOD, Superoxide dismutase; GSH-Px, Glutathione peroxidase; MDA, Malondialdehyde; T
Caffeic acid phenethyl ester is a potent inhibitor of HIF prolyl hydroxylase: structural analysis and pharmacological implication
Keywords: CAPE، اسید کافئین فنیل استریل; CAPE, caffeic acid phenethyl ester; CNAPE, cinnamic acid phenethyl ester; DMC, dimethoxycinnamic acid phenethyl ester; DMDHC, dimethoxydihydrocinnamic acid phenethyl ester; DHC, dihydrocaffeic acid phenethyl ester; CAME, caffeic acid methyl ester; CAPEN,
Antitumor progression potential of caffeic acid phenethyl ester involving p75NTR in C6 glioma cells
Keywords: CAPE، اسید کافئین فنیل استریل; CAPE, caffeic acid phenethyl ester; GFAP, glial fibrillary acidic protein; MMP, matrix metalloproteinase; NGF, nerve growth factor; p75NTR, p75 neurotrophin receptorCaffeic acid phenethyl ester; Differentiation; Glioma; Invasion; p75 neurotrophin receptor
Regulation of arginine transport and metabolism by Protein Kinase Cα in endothelial cells: stimulation of CAT2 transporters and arginase activity
Keywords: CAPE، اسید کافئین فنیل استریل; CAA, Cationic Amino Acid; CAPE, Caffeic Acid Phenethyl Ester; EBSS, Earle's Balanced Salt Solution; eNOS, endothelial Nitric Oxide Synthase; FBS, Fetal Bovine Serum; HAEC, Human Aortic Endothelial cells; HF, Human Fibroblasts; HUVEC, Human Umbilical Vein
Caffeic acid phenethyl ester protects rabbit brains against permanent focal ischemia by antioxidant action: A biochemical and planimetric study
Keywords: CAPE، اسید کافئین فنیل استریل; ANOVA, one-way analysis of variance; CAPE, caffeic acid phenethyl ester; CAT, catalase; DTNB, dinitro2,2-dithiobenzoic acid; GSH, reduced glutathione; MCA, middle cerebral artery; MCAO, middle cerebral artery occlusion; MDA, malondialdehyde; NO, nitric ox
Caffeic acid phenethyl ester protects mice from lethal endotoxin shock and inhibits lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in RAW 264.7 macrophages via the p38/ERK and NF-κB pathways
Keywords: CAPE، اسید کافئین فنیل استریل; CAPE, caffeic acid phenethyl ester; iNOS, inducible nitric oxide synthase; PGE2, prostaglandin E2; COX-2, cyclooxygenase-2; TNF-α, tumor necrosis factor-α; IL-1β, interleukin-1β; NF-κB, nuclear factor-κB; IκB, inhibitory factor of NF-kB; MAPK, mitogen-act
DNA damage induced by caffeic acid phenyl ester in the presence of Cu(II) ions: Potential mechanism of its anticancer properties
Keywords: CAPE، اسید کافئین فنیل استریل; CAPE, caffeic acid phenethyl ester; ROS, reactive oxygen species; CA, caffeic acid; FA, ferulic acid; EF, ethyl ferulate; O2-, superoxide anion; EDTA, ethylene diamine tetraacetic acid; SOD, superoxide dismutases; DMSO, dimethyl sulfoxideCaffeic acid phen
CAPE (caffeic acid phenethyl ester) stimulates glucose uptake through AMPK (AMP-activated protein kinase) activation in skeletal muscle cells
Keywords: CAPE، اسید کافئین فنیل استریل; ACC, acetyl-CoA carboxylase; AICAR, 5-aminoimidazole-4-carboxy-amide-1-D-ribofuranoside; AMPK, AMP-activated protein kinase; CAPE, caffeic acid phenethyl ester; PI3K, phosphoinositide 3-kinaseCAPE; AMPK; Akt; Glucose uptake
Structure-activity relationship of C6-C3 phenylpropanoids on xanthine oxidase-inhibiting and free radical-scavenging activities
Keywords: CAPE، اسید کافئین فنیل استریل; CAPE, caffeic acid phenethyl ester; DHR123, dihydrorhodamine 123; DMEM, Dulbecco's modified Eagle's medium; DMPO, 5,5-dimethyl-1-pyrroline-N-oxide; DPPH, 1,1-diphenyl-2-picrylhydrazyl hydrate; FBS, fetal bovine serum; LPS, lipopolysaccharide; MEM, minimum
Propolis and the immune system: a review
Keywords: CAPE، اسید کافئین فنیل استریل; ACF, aberrant crypt foci; ADCC, antibody-dependent cellular cytotoxicity; AST, aspartate aminotransferase; BSA, bovine serum albumin; CAPE, caffeic acid phenethyl ester; Con A, concanavalin A; Erk-2, extracellular-signal-regulated kinase; GC, gas-chromato
The effect of caffeic acid phenethyl ester (CAPE) on histopathological changes in testicular ischemia-reperfusion injury
Keywords: CAPE، اسید کافئین فنیل استریل; MPO, myeloperoxidase; iNOS, inducible nitric oxide synthases; NO, nitric oxide; NOS, nitric oxide synthase; CAPE, caffeic acid phenethyl ester; T/D, torsion/detorsion; ROS, reactive oxygen species; I/R, ischemia/reperfusionTesticular ischemia-reperfusion;
Altered iron homeostasis involvement in arsenite-mediated cell transformation
Keywords: CAPE، اسید کافئین فنیل استریل; CAPE, caffeic acid phenethyl ester; HOS, human osteogenic sarcoma; As-T-HOS, arsenic-transformed HOS; As-8w-HOS, HOS cells treated for 8 weeks with arsenite; DMT, divalent metal transporter; FAC, ferric ammonium citrate; FBS, fetal bovine serum; IRE, iron
Enhancement of caffeic acid phenethyl ester on all-trans retinoic acid-induced differentiation in human leukemia HL-60 cells
Keywords: CAPE، اسید کافئین فنیل استریل; APL, acute promyelocytic leukemia; ATRA, all-trans retinoic acid; CAPE, caffeic acid phenethyl ester; EMSA, electrophoretic mobility shift assay; NBT, nitroblue tetrazolium; RAR, retinoic acid receptor; RARE, retinoic acid response elementsCaffeic acid ph
Characterization of the pro-inflammatory signaling induced by protein acetylation in microglia
Keywords: CAPE، اسید کافئین فنیل استریل; CAPE, caffeic acid phenethyl ester; Dexa, dexamethasone; EMSA, electrophoretic mobility shift assay; FBS, fetal bovine serum; HDAC, histone deacetylase; IKK2, I kappa B kinase 2 (IKK beta); IL-6, interleukin-6; JNK, c-Jun N-terminal kinase; LDH, lactate d
Mechanism of macrophage activation by (1,4)-α-d-glucan isolated from Tinospora cordifolia
Keywords: CAPE، اسید کافئین فنیل استریل; BRM, biological response modifier; CAPE, caffeic acid phenethyl ester; CR3, complement receptor 3; DMEM, Dulbecco's Modified Eagle Medium; ELISA, enzyme-linked immunosorbent assay; FITC, fluorescein isothiocyanate; GAPDH, glyceraldehyde-3-phosphate dehydr
The selective inhibition of nitric oxide production in the avian macrophage cell line HD11
Keywords: CAPE، اسید کافئین فنیل استریل; ALLN, N-acetyl-leu-leu-nor leucinal; CAPE, caffeic acid phenethyl ester; eNOS, endothelial nitric oxide synthase; EG, Enterococcus gallinarum; IκB, I kappa B; iNOS, inducible nitric oxide synthase; IFNγ, interferon-γ; KP, Klebsiella pneumoniae; MAPK, mito
Regulation of inflammation and redox signaling by dietary polyphenols
Keywords: CAPE، اسید کافئین فنیل استریل; AP-1, activator protein 1; ARE, antioxidant response elements; ATF1, activating transcription factor; CAPE, caffeic acid phenethyl ester; COPD, chronic obstructive pulmonary disease; COX-2, cyclooxygenase-2; CRE, cyclic AMP response element; CREB, CRE-bin
Molecular targets of dietary agents for prevention and therapy of cancer
Keywords: CAPE، اسید کافئین فنیل استریل; AP-1, activator protein-1; CAPE, caffeic acid phenethyl ester; Cdk, cyclin-dependent kinase; COX-2, cyclooxygenase-2; cPLA2, phospholipase A; CSF, colony-stimulating factors; DIM, 1,1-bis(3′-indolyl)-1-(p-substituted phenyl) methanes; DMBA, dimethyl-benz(