Aged garlic extract protects against doxorubicin-induced cardiotoxicity in rats
Keywords: سمیت قلبی; Doxorubicin; Aged garlic extract; Cardiotoxicity;
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A multicentre Phase II study of non-pegylated liposomal doxorubicin in combination with trastuzumab and docetaxel as first-line therapy in metastatic breast cancer
Keywords: سمیت قلبی; Non-pegylated liposomal doxorubicin; Docetaxel; Trastuzumab; Phase II trial; Cardiotoxicity; Metastatic breast cancer
Tomotherapy and Multifield Intensity-Modulated Radiotherapy Planning Reduce Cardiac Doses in Left-Sided Breast Cancer Patients With Unfavorable Cardiac Anatomy
Keywords: سمیت قلبی; Breast cancer; Radiation; Cardiotoxicity; IMRT; Tomotherapy;
Cardioprotective effect of Lagenaria siceraria (LS) fruit powder in isoprenalin-induced cardiotoxicity in rats
Keywords: سمیت قلبی; Lagenaria siceraria (LS) fruit powder; Isoprenalin; Cardiotoxicity;
Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats
Keywords: سمیت قلبی; Cranberry; Doxorubicin; Cardiotoxicity; Antioxidation
Pretreatment with quercetin ameliorates lipids, lipoproteins and marker enzymes of lipid metabolism in isoproterenol treated cardiotoxic male Wistar rats
Keywords: سمیت قلبی; Cardiotoxicity; Isoproterenol; Lipid; Lipoprotein; Quercetin
Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model
Keywords: سمیت قلبی; Doxorubicin; l-carnitine; OCTN2 (organic cation/carnitine transporter); H-FABP (heart fatty acid binding protein); Gene expression; Cardiotoxicity
Recombinant human interleukin-1 receptor antagonist protects mice against acute doxorubicin-induced cardiotoxicity
Keywords: سمیت قلبی; Doxorubicin; Recombinant human interleukin-1 receptor antagonist; Cardiotoxicity
ErbB signaling in cardiac development and disease
Keywords: سمیت قلبی; ErbB; Heart development; Heart disease; Mouse models; Cardiotoxicity; Therapeutics
A pH/Enzyme-responsive tumor-specific delivery system for doxorubicin
Keywords: سمیت قلبی; Doxorubicin; pH/enzyme-responsive; Cardiotoxicity; Gelatinase
Autophagy plays an important role in Sunitinib-mediated cell death in H9c2 cardiac muscle cells
Keywords: سمیت قلبی; Sunitinib; Cardiotoxicity; Antitumor drugs; Autophagy
Crotoxin potentiates L-type calcium currents and modulates the action potential of neonatal rat cardiomyocytes
Keywords: سمیت قلبی; Snake venom; Phospholipase A2; L-type Ca2+ channels; Cardiac electrical activity; Cardiotoxicity
Cytotoxicity and ultrastructural changes in H9c2(2-1) cells treated with pavetamine, a novel polyamine
Keywords: سمیت قلبی; Cardiotoxicity; Gousiekte; H9c2(2-1) cell line; Mitochondria; Pavetamine; PolyamineATP, adenosine triphosphate; Ca2+, calcium; CsA, cyclosporin A; DMEM, Dulbecco's Modified Eagle's Medium; EC50, half maximal effective concentration; FCS, fetal calf serum;
Imatinib does not induce cardiotoxicity at clinically relevant concentrations in preclinical studies
Keywords: سمیت قلبی; ADP; adenosine diphosphate; ATP; adenosine triphosphate; AUC; area under the concentration-time curve; Cmax; maximal concentration; c-Abl; C-terminus of Abl gene; CML; chronic myeloid leukemia; ED; end-diastole; ER; endoplasmic reticulum; ES; end-systol
Identification of potential genomic biomarkers for early detection of chemically induced cardiotoxicity in rats
Keywords: سمیت قلبی; Biomarker; Cardiotoxicity; Rat; Toxicogenomics
Damage to some contractile and cytoskeleton proteins of the sarcomere in rat neonatal cardiomyocytes after exposure to pavetamine
Keywords: سمیت قلبی; Actin; Cardiotoxicity; Cytoskeleton; F-actin; Gousiekte; Myosin; Pavetamine; Polyamine; Rat neonatal cardiomyocytes; TitinBSA, bovine serum albumin; DMEM, Dulbecco's Modified Eagle's Medium; LDH, lactate dehydrogenase; LSCM, laser scanning confocal micros
Tomorrow's targeted therapies in breast cancer patients: What is the risk for increased radiation-induced cardiac toxicity?
Keywords: سمیت قلبی; Breast cancer; Cardiotoxicity; Antiangiogenesis; Trastuzumab; Radiotherapy
Cardiotoxic effects of Loxosceles intermedia spider venom and the recombinant venom toxin rLiD1
Keywords: سمیت قلبی; Loxosceles intermedia spider; Loxtox monoclonal antibody; Ca2+ transient; Cardiomyocytes path clamp and confocal microscopy; Cardiotoxicity
Cardiac side-effects of cancer chemotherapy
Keywords: سمیت قلبی; Cancer; Chemotherapy; Cardiotoxicity;
Impact of biomarker development on drug safety assessment
Keywords: سمیت قلبی; Safety biomarkers; Nephrotoxicity; Hepatoxicity; Cardiotoxicity; Vascular injury; Personalized medicine
Cardioprotective effect of ‘Khamira Abresham Hakim Arshad Wala’ a Unani formulation in isoproterenol-induced myocardial necrosis in rats
Keywords: سمیت قلبی; Abresham; Unani; Isoproterenol; Cardiotoxicity; Oxidative stress
Acute cardiotoxicity with concurrent trastuzumab and radiotherapy including internal mammary chain nodes: A retrospective single-institution study
Keywords: سمیت قلبی; Breast cancer; Trastuzumab; Cardiotoxicity; Internal mammary chain irradiation; Radiotherapy
Appraising cardiotoxicity associated with liposomal doxorubicin by means of tissue Doppler echocardiography end-points: Rationale and design of the LITE (Liposomal doxorubicin–Investigational chemotherapy–Tissue Doppler imaging Evaluation) randomized pilo
Keywords: سمیت قلبی; Anthracycline; Cardiotoxicity; Echocardiography; Randomized clinical trial; Tissue Doppler imaging
Oral glutamine protects against cyclophosphamide-induced cardiotoxicity in experimental rats through increase of cardiac glutathione
Keywords: سمیت قلبی; Cyclophosphamide; Heart; Cardiotoxicity; Glutamine; Glutathione;
Cardiotoxicité après un traitement au long cours par chloroquine chez deux patientes lupiques
Keywords: سمیت قلبی; Lupus; Chloroquine érythémateuse; Cardiotoxicité; Lupus; Erythematosus chloroquine; Cardiotoxicity;
Effect of methimazole treatment on doxorubicin-induced cardiotoxicity in mice
Keywords: سمیت قلبی; Methimazole; Doxorubicin; Cardiotoxicity; Drug–drug interaction
Cardiotoxicity associated with trastuzumab in normal clinical practice
Keywords: سمیت قلبی; HER2-breast cancer; Cardiotoxicity; Trastuzumab; Adverse effects; Cáncer de mama HER-2; Cardiotoxicidad; Trastuzumab; Efectos adversos;
Evaluation of the usefulness of biomarkers for cardiac and skeletal myotoxicity in rats
Keywords: سمیت قلبی; Cardiotoxicity; Skeletal myotoxicity; Rats; Combinatorial safety biomarkers
Improving the therapeutic index of anthracycline chemotherapy: Focus on liposomal doxorubicin (Myocet™)
Keywords: سمیت قلبی; Liposomal doxorubicin; Anthracycline; Cardiotoxicity; Metastatic breast cancer
Ostreolysin induces sustained contraction of porcine coronary arteries and endothelial dysfunction in middle- and large-sized vessels
Keywords: سمیت قلبی; Aegerolysin; Ca2+ channel blocker; Cardiotoxicity; Histopathology; Immunofluorescence; Ostreolysin; Pleurotus ostreatus;
The iron chelator Dp44mT does not protect myocytes against doxorubicin
Keywords: سمیت قلبی; Dp44mT; Doxorubicin; Iron; Myocyte; Cardiotoxicity;
Cardiovascular Effects of Tyrosine Kinase Inhibitors Used for Gastrointestinal Stromal Tumors
Keywords: سمیت قلبی; Gastrointestinal stromal tumor; Cancer; Cardiotoxicity; Tyrosine kinase inhibitors; Imatinib; Sunitinib
Cardiotoxicity of calmidazolium chloride is attributed to calcium aggravation, oxidative and nitrosative stress, and apoptosis
Keywords: سمیت قلبی; Calmidazolium; H9c2 cells; Cardiotoxicity; Oxidative stress; Mitochondrial damage; Cardiomyocytes; Free radicals
Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer
Keywords: سمیت قلبی; Doxorubicin; Cardiotoxicity; Hepatotoxicity; Fullerenol; Oxidative stress; Colorectal cancerDox, doxorubicin; Frl, fullerenol; DMSO, dimethyl-sulfoxide; DMH, 1,2-dimethyl-hydrazine; CK, creatine kinase; ALT, alanine aminotransferase; AST, aspartate aminot
Studies on self-aggregation of anthracycline drugs by restrained molecular dynamics approach using nuclear magnetic resonance spectroscopy supported by absorption, fluorescence, diffusion ordered spectroscopy and mass spectrometry
Keywords: سمیت قلبی; 4′-Epiadriamycin, adriamycin and daunomycin; 2D nuclear Overhauser enhancement spectroscopy; Restrained molecular dynamics; Electron spray ionization mass spectrometry; Diffusion ordered spectroscopy; Cardiotoxicity
Cardiovascular Complications of Cancer Therapy : Incidence, Pathogenesis, Diagnosis, and Management
Keywords: سمیت قلبی; cancer; cardiotoxicity; therapy; heart failureACE, angiotensin-converting enzyme; ACS, acute coronary syndrome; ATE, arterial thrombotic event; ATP, adenosine triphosphate; CMP, cardiomyopathy; CTCL, cutaneous T-cell lymphoma; DVT, deep vein thrombosis; F
Emergencies Related to Cancer Chemotherapy and Hematopoietic Stem Cell Transplantation
Keywords: سمیت قلبی; Chemotherapy; Stem cell transplant; Neutropenia; Anemia; Cardiotoxicity; Graft-versus-host disease;
Validation of a guinea pig Langendorff heart model for assessing potential cardiovascular liability of drug candidates
Keywords: سمیت قلبی; Arrhythmia; Cardiotoxicity; ECG; Guinea pig; Hemodynamic; Langendorff heart; Methods; Monophasic action potential; QT/QTc; Torsade de Pointes
Beta-blocker and angiotensin-converting enzyme inhibitor may limit certain cardiac adverse effects of clozapine
Keywords: سمیت قلبی; Clozapine; Cardiotoxicity; β-Blockers
Clozapine-induced myocarditis: Role of catecholamines in a murine model
Keywords: سمیت قلبی; Atypical antipsychotic; Norepinephrine; Epinephrine; TNF-alpha; Cardiotoxicity; Balb/C mice
Treatment of HER-2 positive breast cancer
Keywords: سمیت قلبی; Breast neoplasms; c-erbB-2; Anthracyclines; Taxanes; Trastuzumab; Cardiotoxicity;
Prone Positioning Causes the Heart To Be Displaced Anteriorly Within the Thorax: Implications for Breast Cancer Treatment
Keywords: سمیت قلبی; Breast cancer; Radiotherapy technique; Prone position; Heart movement; Cardiotoxicity;
Cardiac blood biomarkers in patients receiving thoracic (chemo)radiation
Keywords: سمیت قلبی; Cardiotoxicity; Troponin; CK-MB; BNP; Radiation; Lung cancer
Metabolic context affects hemodynamic response to bupivacaine in the isolated rat heart
Keywords: سمیت قلبی; Bupivacaine; Cardiotoxicity; Fatty acid metabolism; Local anesthesia; Isolated heart; Metabolic modulation
An evaluation of the cardiotoxicity of imatinib mesylate
Keywords: سمیت قلبی; Imatinib; Cardiotoxicity; Chronic myeloid leukaemia; Ventricular function; BNP
Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats
Keywords: سمیت قلبی; ADR, adriamycin; GSH, reduced glutathione; i.p., intraperitoneally; LDH, lactate dehydrogenase; CPK, creatine phosphokinase; MDA, malondialdehydeAdriamycin; Silymarin; Cardiotoxicity; Nephrotoxicity; Lipid peroxidation; GSH
Dose dependent effects of standardized nose-horned viper (Vipera ammodytes ammodytes) venom on parameters of cardiac function in isolated rat heart
Keywords: سمیت قلبی; Cardiotoxicity; Isolated heart; Snake venom; Vipera ammodytes ammodytes
Morphine is protective against doxorubicin-induced cardiotoxicity in rat
Keywords: سمیت قلبی; Doxorubicin; Morphine; Cardiotoxicity; ECG
Ability of suramin to antagonize the cardiotoxic and some enzymatic activities of Bothrops jararacussu venom
Keywords: سمیت قلبی; Suramin; Bothrops jararacussu venom; Cardiotoxicity; Proteolytic and phospholipase A2 activityPLA2, phospholipases A2; BthTX-I, Bothropstoxin-I; BthTX-II, Bothropstoxin-II
The use of liposomal anthracycline analogues for childhood malignancies: A systematic review
Keywords: سمیت قلبی; Liposomal anthracyclines; Cardiotoxicity; Paediatric oncology; Adverse drug events; Efficacy; Systematic review;