Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure–activity relationship for anti-inflammatory drug
Keywords: NSAID; COX-2/COX-1 selectivity; Orally active COX-2 inhibitor; Carrageenan-induced oedema; InflammationAA, arachidonic acid; COX, cyclooxygenase (or endoperoxidase, or prostaglandin G/H synthase, EC 1.14.99.1); PG, prostaglandin; PGH2, prostaglandin H2; P