Keywords: CCl4، تتراکلرید کربن; Allyl isothiocyanate; Carbon tetrachloride; Hepatoprotection; Heme oxygenase-1AITC, allyl isothiocyanate; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CAT, catalase; CCl4, carbon tetrachloride; DAB, diaminobenzidine; HO-1, heme oxygenas
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Keywords: CCl4، تتراکلرید کربن; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BET, betaine; CAT, catalase; CCl4, carbon tetrachloride; CHOL, cholesterol; COL1A1, type I collagen; ECM, extracellular matrix; FRAP, ferric reducing antioxidant power; GSH, glutathione; GSH-
Keywords: CCl4، تتراکلرید کربن; Liver fibrosis; SOCS1; Dimethylnitrosamine; Carbon tetrachloride; Hepatic stellate cells; PDGFALT, alanine transferase; CCl4, carbon tetrachloride; DMN, dimethylnitrosamine; ECM, extra-cellular matrix; GBSS, Gey’s Balanced Salt Solution; HCC, hepatocellul
Keywords: CCl4، تتراکلرید کربن; ECM, extracellular matrix; aHSCs, activated hepatic stellate cells; CCl4, carbon tetrachloride; BDL, bile duct ligation; qHSCs, quiescent hepatic stellate cells; GFAP, glial fibrillar acidic protein; TGFβ, transforming growth factor beta; PDGF, platelet-d
Keywords: CCl4، تتراکلرید کربن; CCL4, carbon tetrachloride; C/EBPa, CCAAT/enhancer binding protein alpha; CTGF, connective tissue growth factor; Dlk1, delta-like homolog 1; ERK1/2, extracellular regulated kinases 1 and 2; FGF18, fibroblast growth factor 18; Gfap, glial fibrillary acidic
Keywords: CCl4، تتراکلرید کربن; Hypoxia-Inducible Factors; Liver Fibrosis; Kupffer Cells; Hepatic Stellate CellsBDL, bile duct ligation; CCl4, carbon tetrachloride; Ccr, C-C chemokine receptor; FGF, fibroblast growth factor; HGF, hepatocyte growth factor; HIFs, hypoxia-inducible factors
Keywords: CCl4، تتراکلرید کربن; BDECs, Bile duct epithelial cells; CBDL, Common bile duct ligation; CCl4, Carbon tetrachloride; FCH, Fibrosing cholestatic hepatitis; HSCs, Hepatic stellate cells; LECs, Liver endothelial cells; TBIL, Total bilirubin; VEGF, Vascular endothelial growth fac
Keywords: CCl4، تتراکلرید کربن; α-SMA, α-smooth muscle actin; CCl4, carbon tetrachloride; CTGF, connective tissue growth factor; HSC, hepatic stellate cell; MMP-9, matrix metalloproteinase 9; Nrf2, nuclear factor erythroid 2–related factor 2; PDGF, platelet-derived growth factor; TGF-β,
Keywords: CCl4، تتراکلرید کربن; ALT, alanine aminotransferase; ALP, alkaline phosphatase; AMY, amylase; AST, aminotransferase; BUN, blood urea nitrogen; CCl4, carbon tetrachloride; CCl3-radical, trichloromethyl radical; CK, creatine kinase; CRP, C-reactive protein; CYP, cytochrome P450;
Keywords: CCl4، تتراکلرید کربن; α-SMA, alpha smooth muscle actin; CCl4, carbon tetrachloride; HSCs, hepatic stellate cells; IFNγ, interferon gamma; mimIFNγ, interferon gamma peptidomimetic; MHC-II, major histocompatibility complex-II; TIMP-1, tissue inhibitor of matrix metalloproteinase
Keywords: CCl4، تتراکلرید کربن; ALT, alanine aminotransferase; CCl4, carbon tetrachloride; DTNB, dithio-bis-nitrobenzoic acid; GPx, glutathione peroxidase; GR, glutathione reductase; i.p., intraperitoneally; Nrf2, nuclear factor erythroid 2-related factor 2; PBS, phosphate buffer saline
Keywords: CCl4، تتراکلرید کربن; a-SMA, a-Smooth Muscle Actin; BM, bone marrow; CCl4, carbon tetrachloride; CK19, Cytokeratin-19; FCM, flow cytometry; FVIII, Factor VIII; G-CSF, Granulocyte-Colony Stimulating Factor; GFP, Green Fluorescent Protein; HSCs, hematopoietic stem cells; IL-6, I
Therapeutic approaches for treating hemophilia A using embryonic stem cells
Keywords: CCl4، تتراکلرید کربن; Bry, brachyury; CCl4, carbon tetrachloride; DAPI, 4′,6-diamidino-2-phenylindole; Dox, doxycycline; EB, embryoid body; ES, embryonic stem; FVIII, factor VIII; FVIII:Ag, factor VIII antigen; FVIII:C, factor VIII activity; FIX, factor IX; GFP, green fluoresc
Chemoprotective Effect of Elettaria Cardamomum against Chemically induced Hepatocellular Carcinoma in Rats by Inhibiting NF-κB, Oxidative Stress, and Activity of Ornithine Decarboxylase
Keywords: CCl4، تتراکلرید کربن; TNF, tumor necrosis factor; IL-1, interlukin-1; NF-κB, nuclear factor-kappaB; AFP, α-feto protein; ODC, ornithine decarboxylase; ALT, alanine transaminase; ALP, alkaline phosphatase; AST, aspartate transaminase; CAT, catalase; CCl4, carbon tetrachloride;
Development of quercetin-phospholipid complex to improve the bioavailability and protection effects against carbon tetrachloride-induced hepatotoxicity in SD rats
Keywords: CCl4، تتراکلرید کربن; QT, quercetin; QT-PC, quercetin-phospholipid complex; CCl4, carbon tetrachloride; IR, infrared spectroscopy; DSC, differential scanning calorimetry; PXRD, powder X-ray diffraction; SD, Sprague-Dawley; AST, aspartate aminotransferase; ALT, alanine aminotra
Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice
Keywords: CCl4، تتراکلرید کربن; ALT, alanine aminotransaminase; CCl4, carbon tetrachloride; COX-2, cyclooxygenase-2; DBM, DNA binding domain mutant; ERK5, extracellular signal-regulated kinase 5; HBV, hepatitis B virus; LPS, lipopolysaccharide; NF-κB, nuclear factor κB; PARP, poly (ADP-
4-Phenylbutyric acid regulates CCl4-induced acute hepatic dyslipidemia in a mouse model: A mechanism-based PK/PD study
Keywords: CCl4، تتراکلرید کربن; ER, Endoplasmic reticulum; 4-PBA, 4-Phenylbutyric acid; LDL, Low-density lipoprotein; HDL, High-density lipoprotein; PDI, Protein disulfide isomerase; CCl4, Carbon tetrachloride; CYP2E1, Cytochrome P450 2E1; ApoB, Apolipoprotein B; TG, Triglyceride; PK, P
Interleukin-15 receptor α on hepatic stellate cells regulates hepatic fibrogenesis in mice
Keywords: CCl4، تتراکلرید کربن; IL-15RαKO, IL-15Rα knockout; IL-15, interleukin-15; CD8+ T, cytotoxic T; NK, natural killer; NKT, natural killer T; DC, dendritic cell; BM, bone marrow; HSC, hepatic stellate cell; CCl4, carbon tetrachloride; BDL, bile duct ligation; BMT, bone marrow tran
Chlordecone potentiates hepatic fibrosis in chronic liver injury induced by carbon tetrachloride in mice
Keywords: CCl4، تتراکلرید کربن; AST, aspartate aminotransferase; ALT, alanine aminotransferase; CD, chlordecone; CCl4, carbon tetrachloride; α-SMA, α-smooth muscle actin; ECM, extracellular matrixLiver; Fibrosis; Chlordecone; CCl4; Collagen; Kepone
Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway
Keywords: CCl4، تتراکلرید کربن; HSCs, hepatic stellate cells; Sirt1, Sirtuin 1; CCl4, carbon tetrachloride; BDL, bile duct ligation; DMN, dimethylnitrosamine; HO-1, heme oxygenase-1; GST, glutathione-S-transferase; GCLC, glutathione cysteine ligase catalytic subunit; GCLM, glutathione c
Belamcanda chinensis (L.) DC-An ethnopharmacological, phytochemical and pharmacological review
Keywords: CCl4، تتراکلرید کربن; AMPK, Adenosine 5′-Monophosphate-Activated Protein Kinase; COX-1, Cyclooxygenase-1; COX-2, Cyclooxygenase-2; Ca2+-ATPase, Calcium Pump; CPAE, Calf Pulmonary Arterial Endothelial; CCl4, Carbon Tetrachloride; DPPH, 1,1-Diphenyl-2-Picrylhydrazyl; ETOH, Ethan
Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury
Keywords: CCl4، تتراکلرید کربن; APAP; Mouse Model; Gene Regulation; Pharmacologic TreatmentALF, acute liver failure; AMPK, adenosine monophosphate-activated protein kinase; APAP, acetaminophen; CCl4, carbon tetrachloride; D-GalN, D-galactosamine; DILI, drug-induced liver injury; IP, int
Self-nanoemulsifying particles of coenzyme Q10 with improved nutraceutical potential
Keywords: CCl4، تتراکلرید کربن; ALT, alanine aminotransferase; ANOVA, analysis of variance; AST, aspartate aminotransferase; β-NADH, nicotinamide adenine dinucleotide; CCl4, carbon tetrachloride; Cmax, maximum concentration; CoQ10, coenzyme Q10; DLS, dynamic light scattering; DSC, diffe
Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice
Keywords: CCl4، تتراکلرید کربن; CREB, cAMP-response element-binding protein; CBP, CREB-binding protein; CCl4, carbon tetrachloride; BDL, bile duct ligation; PBDL, partial BDL; HSC, hepatic stellate cell; MMP, matrix metalloproteinase; TGF-β, transforming growth factor; HCV, hepatitis C
Protective effect of extracellular polysaccharides from Grifola frondosa mycelium on CCl4-injured liver in vitro
Keywords: CCl4، تتراکلرید کربن; GF, Grifola frondosa; GFP, Grifola frondosa polysaccharide; CCL4, carbon tetrachloride; CYP2E1, cytochrome P4502E1; TNF-α, tumor necrosis factor alpha; ROS, reactive oxygen speciesGrifola frondosa; L-02 cell line; Liver injured; Protective effect; In vitr
Ubiquitin C-terminal hydrolase 1: A novel functional marker for liver myofibroblasts and a therapeutic target in chronic liver disease
Keywords: CCl4، تتراکلرید کربن; HSC, hepatic stellate cells; UCHL1, ubiquitin c-terminal hydrolase; Ub, ubiquitin; DUB, deubiquitinase; USP, ubiquitin specific protease; IPF, idiopathic pulmonary fibrosis; CCl4, carbon tetrachloride; BDL, bile duct ligation; qHSC, quiescent hepatic stel
Activation of Slit2-Robo1 signaling promotes liver fibrosis
Keywords: CCl4، تتراکلرید کربن; α-SMA, α-smooth muscle actin; CCl4, carbon tetrachloride; ECM, extracellular matrix; HSCs, hepatic stellate cells; Robo1/2+/− mice, Robo1+/−Robo2+/− double heterozygotes mice; Slit2-Tg mice, Slit2-transgenic mice; TGF-β1, transforming growth factor-βα-SMA
Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice
Keywords: CCl4، تتراکلرید کربن; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BSA, bovine serum albumin; CCl4, carbon tetrachloride; COX-2, cyclooxygenase-2; CYP2E1, cytochrome P450 2E1; DMSO, dimethyl sulphoxide; DPPH, 2,2-diphenyl-1-picryl-hydrazyl; DTNB, 5,5′-dithio
Ferulic acid suppresses activation of hepatic stellate cells through ERK1/2 and Smad signaling pathways in vitro
Keywords: CCl4، تتراکلرید کربن; α-SMA, α-smooth muscle actin; ANOVA, one-way analysis of variance; CCl4, carbon tetrachloride; ECM, extracellular matrix; ELISA, enzyme-linked immunosorbent assay; ERK1/2, extracellular signal-regulated kinases 1 and 2; FA, ferulic acid; FAK, focal adhesi
Protective effects of ursolic acid in an experimental model of liver fibrosis through Nrf2/ARE pathway
Keywords: CCl4، تتراکلرید کربن; ALT, Alanine aminotransferase; AST, Aspartate aminotransferase; ARE, Antioxidant response elements; CAT, Catalase; CCl4, Carbon tetrachloride; GPx, Glutathione peroxidase; GSH, Reduced glutathione; GST, Glutathione S-transferase; HO-1, Heme oxygenase-1; i
Biopharmaceutical characterization of nanocrystalline solid dispersion of coenzyme Q10 prepared with cold wet-milling system
Keywords: CCl4، تتراکلرید کربن; ALT, alanine aminotransferase; ANOVA, analysis of variance; AST, aspartate aminotransferase; AUC0-inf, area under the curve of blood concentration vs. time from t = 0 to t = ∞ after oral administration; BA, bioavailability; CCl4, carbon tetrachloride; Cma
Protective effects of neohesperidin dihydrochalcone against carbon tetrachloride-induced oxidative damage in vivo and in vitro
Keywords: CCl4، تتراکلرید کربن; ALT, alanine transaminase; AST, aspartate transaminase; CAT, catalase; CCl4, carbon tetrachloride; COX-2, cyclooxygenase-2; DAB, 3,3′-diaminobenzidine tetrahydrochloride; DCFH-DA, 2′,7′-dichlorodihydrofluorescein diacetate; GP-X, glutathione peroxidase; G
Hautriwaic acid as one of the hepatoprotective constituent of Dodonaea viscosa
Keywords: CCl4، تتراکلرید کربن; CCl4, carbon tetrachloride; ALT, alanine aminotransferase; AST, aspartate transaminase; ALP, alkaline phosphatase; MeOH, methanolic extract; EtOAc, ethyl acetate; H2O, aqueousLiver injury; Carbon tetrachloride; Hepatoprotective; Dodonaea viscosa; In vivo;
Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway
Keywords: CCl4، تتراکلرید کربن; α-SMA, α-smooth muscle actin; ALT, alanine aminotransferase; AMPK, AMP-activated protein kinase; AST, aspartate aminotransferase; AO, acridine orange; AVO, acidic vesicular organelles; CCl4, carbon tetrachloride; DCFH-DA, 2′,7′-dichlo-rofluore-scein diace
Trianthema portulacastrum Linn. exerts chemoprevention of 7,12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in rats
Keywords: CCl4، تتراکلرید کربن; AI, apoptotic index; CCl4, carbon tetrachloride; DENA, diethylnitrosamine; DMBA, 7,12-dimethylbenz(a)anthracene; LI, labeling index; PAH, polycyclic aromatic hydrocarbon; PCNA, proliferating cell nuclear antigen; TCF, T cell factor; TPE, Trianthema portul
Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation
Keywords: CCl4، تتراکلرید کربن; ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate transaminase; Caspase-3, cysteinyl aspartate specific proteinase-3; Caspase-9, cysteinyl aspartate specific proteinase-9; CCl4, carbon tetrachloride; COX-2, cyclooxygenase-2; CYP2E1, cyt
Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don: A comparative review on traditional uses, phytochemistry and pharmacology
Keywords: CCl4، تتراکلرید کربن; CNS, central nervous system; CCl4, carbon tetrachloride; DPPH, 2,2-diphenyl-1-picrylhydrazyl; NIDDM, non-insulin dependent diabetes mellitus; NO, nitric oxide; NSAIDs, nonsteroidal anti-inflammatory drugs; ROS, radicals, reactive oxygen species; SGLT, sod
Comparative analysis of gene expression profiles of acute hepatic failure and that of liver regeneration in rat
Keywords: CCl4، تتراکلرید کربن; A, absent; AHF, acute hepatic failure; CCl4, carbon tetrachloride; HGF, hepatocyte growth factor; LR, liver regeneration; M, marginal; NC, normal control; P, present; PH, partial hepatectomy; RT-PCR, real-time polymerase chain reaction; SD, Sprague–Dawley
Physicochemical and biopharmaceutical characterization of amorphous solid dispersion of nobiletin, a citrus polymethoxylated flavone, with improved hepatoprotective effects
Keywords: CCl4، تتراکلرید کربن; ALT, alanine aminotransferase; ANOVA, analysis of variance; AST, aspartate aminotransferase; Ceq, equilibrium solubility; CCl4, carbon tetrachloride; CYP, cytochrome P450; DLS, dynamic light scattering; DSC, differential scanning calorimetry; H&E, hematox
Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats
Keywords: CCl4، تتراکلرید کربن; GA, Gentiana asclepiadea L.; GAA, Gentiana asclepiadea L. methanol aerial parts extract; GAR, Gentiana asclepiadea L. methanol roots extract; CCl4, carbon tetrachloride; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phospha
Liver carcinogenesis: Rodent models of hepatocarcinoma and cholangiocarcinoma
Keywords: CCl4، تتراکلرید کربن; CCA, cholangiocarcinoma; CCl4, carbon tetrachloride; CDD, choline deficient diet; DEN, N-nitrosodiethylamine; HCC, hepatocellular carcinoma; NAFLD, non-alcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; PB, phenobarbital; PH, partial hepat
Curcumin ameliorates intrahepatic angiogenesis and capillarization of the sinusoids in carbon tetrachloride-induced rat liver fibrosis
Keywords: CCl4، تتراکلرید کربن; CCl4, carbon tetrachloride; ECM, extracellular matrix; HSC, hepatic stellate cells; vWF, von Willebrand factor; TEM, transmission electron microscopy; HIF-1α, hypoxia-inducible factor-1α; VEGF, vascular endothelial growth factor; VEGFR, vascular endotheli
Sphingosine-1-phosphate: A Janus-faced mediator of fibrotic diseases
Keywords: CCl4، تتراکلرید کربن; BAL, bronchoalveolar lavage; BMSC, bone marrow-derived stem cell; CCl4, carbon tetrachloride; Col, collagen; CTGF, connective tissue growth factor; DN, diabetic nephropathy; EC, epithelial cell; ERK, extracellular signal-regulated kinase; FB, fibroblast;
Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK
Keywords: CCl4، تتراکلرید کربن; CYP2E1, cytochrome P4502E1, E47 cells, HepG2 cells which express CYP2E1; C34 cells, HepG2 cells which do not express CYP2E1; AA, arachidonic acid; BSO, L-buthionine sulfoximine; CCl4, carbon tetrachloride; 3-MA, 3-methyadenine; Rap, rapamycin; NAC, N-acet
Antifibrotic effects of glycyrrhizin and matrine in vitro and in vivo
Keywords: CCl4، تتراکلرید کربن; Glycyrrhizin; Matrine; HSC-T6 cell; Carbon tetrachloride; Hepatic fibrosis; Rat modelMat, Matrine; Gly, Glycyrrhizin; ECM, Extracellular matrix; HSCs, Hepatic stellate cells; CCL4, Carbon tetrachloride; HA, Hexadecenoic acid; LN, Laminin; PC-III, Procollg
Agaricus blazei Murill as an efficient hepatoprotective and antioxidant agent against CCl4-induced liver injury in rats
Keywords: CCl4، تتراکلرید کربن; AbM, Agaricus blazei Murill; CCl4, carbon tetrachloride; AST, aspartate transaminase; ALT, alanine transaminase; LDH, lactate dehydrogenase; GR, glutathione reductase; GSH, glutathione; MDA, malondialdehyde; vit. C, vitamin C; vit. E, vitamin EAgaricus bl
Loss of c-Met accelerates development of liver fibrosis in response to CCl4 exposure through deregulation of multiple molecular pathways
Keywords: CCl4، تتراکلرید کربن; HGF, hepatocyte growth factor; NAFLD/NASH, non-alcoholic fatty liver disease/steatohepatitis; ECM, extracellular matrix; MMP, matrix metalloproteinase; CCl4, carbon tetrachloride; TGF-β, transforming growth factor β; PDGF-β, platelet derived growth factor
Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice
Keywords: CCl4، تتراکلرید کربن; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BSA, bovine serum albumin; CCl4, carbon tetrachloride; COX-2, cyclooxygenase; DTNB, 5,5′-dithiobis-(2-nitrobenzoic acid); EDTA, ethylenediaminetetraacetic acid; GR, glutathione reductase; GSH
Traditional extract of Pithecellobium dulce fruits protects mice against CCl4 induced renal oxidative impairments and necrotic cell death
Keywords: CCl4، تتراکلرید کربن; AEPD, aqueous extract of the fruits of Pithecellobium dulce; BSA, bovine serum albumin; BUN, blood urea nitrogen; CCl4, carbon tetrachloride; CDNB, 1-chloro-2,4-dinitrobenzene; DPPH, 2,2-diphenyl-1-picrylhydrazyl; DTNB, 5,5′-dithiobis(2-nitrobenzoic acid)
Calretinin immunoreactivity in normal and carbon tetrachloride-induced nephrotoxic rats
Keywords: CCl4، تتراکلرید کربن; BUN, blood urea nitrogen; CaBPs, calcium binding proteins; CB, calbindin; CR, calretinin; CCl4, carbon tetrachloride; Cr, creatinineCalretinin; Carbon tetrachloride; Kidney; Proximal tubule; Rat