Keywords: کیناز وابسته به سیکلین، CDK; Cdc6; Cdt1; Replication licensing factors; Replication stress; CancerRS, replication stress; DDR, DNA damage response; RLM, replication licensing machinery; pre-RC, pre-replication complex; CDK, cyclin-dependent kinase; ORC, origin recognition complex; Cd
مقالات ISI کیناز وابسته به سیکلین، CDK (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: کیناز وابسته به سیکلین، CDK; Lipid-based anticancer agent; Alkyl phospholipid; PUFA epoxide; Epoxide isostere; Tumor proliferation; Tumor apoptosisAkt, protein kinase B; ALP, alkyl phospholipid; CDK, cyclin-dependent kinase; COX, cyclooxygenase; CYP, cytochrome P450; DHA, docosahexae
Keywords: کیناز وابسته به سیکلین، CDK; AGP, α1-acid glycoprotein; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ATP, adenosine triphosphate; BMP, bone morphogenetic protein; BSA, bovine serum albumin; CAT, catalase; CDK, cyclin-dependent kinase; COX
Keywords: کیناز وابسته به سیکلین، CDK; Cell cycle; Cyclin D1; p16; Pituitary adenoma; RB protein; RecurrenceACTH, Adrenocorticotropic hormone; APA, Anterior pituitary adenoma; CDK, Cyclin-dependent kinase; CDKI, Cyclin-dependent kinase inhibitor; CI, Confidence interval; FPA, Functioning pitui
Keywords: کیناز وابسته به سیکلین، CDK; bFGF2, basic fibroblast growth factor 2; BrdU, 5-bromo-2′-deoxyuridine; Cdk, cyclin-dependent kinase; DCX, doublecortin; DG, dentate gyrus; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ERK, extracellular-signal-regulated kinases 1
Keywords: کیناز وابسته به سیکلین، CDK; Dihydroartemisinin; Artesunate; Infection; Cancer; Autoimmune disorder; AllergyBcl-2, B-cell lymphoma 2; CMV, cytomegalovirus; CDK, cyclin-dependent kinase; DHA, dihydroartemisinin; dsDNA, double-stranded DNA; HBV, hepatitis B virus; HIF-1α, hypoxia-induc
Keywords: کیناز وابسته به سیکلین، CDK; AUC, area under the curve; BPRS, Brief Psychiatric Rating Scale; CDK, cyclin-dependent kinase; CNV, copy number variation; GABA, gamma-aminobutyric acid; GAF, Global Assessment of Functioning; MCM, mini-chromosome maintenance; POLD, polymerase (DNA-direct
PELP1: Structure, biological function and clinical significance
Keywords: کیناز وابسته به سیکلین، CDK; AP1, activator protein 1; AR, androgen receptor; CBP, CREB- binding protein; CDK, cyclin-dependent kinase; DDR, DNA damage response; E2F, E2F transcription factor 1; EGF, epidermal growth factor; EGFR, EGF receptor; ESR1, estrogen receptor alpha; ESR2, Es
Andrographolide inhibits adipogenesis of 3T3-L1 cells by suppressing C/EBPβ expression and activation
Keywords: کیناز وابسته به سیکلین، CDK; CDK, cyclin-dependent kinase; CREB, cAMP response element-binding protein; C/EBP, CCAAT/enhancer-binding protein; EMSA, electrophoretic mobility shift assay; ERK, extracellular signal-regulated kinases; FAS, fatty acid synthase; GSK, glycogen synthase kin
Myostatin propeptide gene delivery by gene gun ameliorates muscle atrophy in a rat model of botulinum toxin-induced nerve denervation
Keywords: کیناز وابسته به سیکلین، CDK; AChR, acetylcholine receptor; BoNT-A, botulinum toxin A; cdk, cyclin-dependent kinase; CMV, cytomegalovirus; DEPC, diethylpyrocarbonate; EGFP, enhanced green fluorescent protein; GAP-43, growth associated protein of 43 kDa; GAPDH, glyceraldehyde-3-phospha
Implications of MDSCs-targeting in lung cancer chemo-immunotherapeutics
Keywords: کیناز وابسته به سیکلین، CDK; Ad, adenoviral; ARG, arginase; ATRA, all-trans-retinoic acid; CAIX, carbonic anhydrase IX; CDK, cyclin-dependent kinase; CTLs, cytotoxic T lymphocytes; DCs, dendritic cells; EGFR, epidermal growth factor receptor; G-CSF, granulocyte colony-stimulating fac
Recent Advances in chemistry and pharmacology of 2-methoxyestradiol: An anticancer investigational drug
Keywords: کیناز وابسته به سیکلین، CDK; ROS, reactive oxygen species; CYP450, cytochrome P450; VEGFR, vascular endothelial growth factor; HIF, hypoxia inducible factor; PDT, podophyllotoxin; Cdk, cyclin-dependent kinase; TNF, tumour necrosis factor2-Methoxyestradiol; Anticancer; Structure-activ
Yeast as a model system to screen purine derivatives against human CDK1 and CDK2 kinases
Keywords: کیناز وابسته به سیکلین، CDK; CDK, cyclin-dependent kinase; cDNA, complementary DNA; DMSO, dimethylsulfoxide; ABC transporter, ATP-binding cassette transporters; GI50, 50% growth inhibition; IC50, half maximal inhibitory concentrationCyclin-dependent kinases; Purine derivatives; Yeast
Low concentrations of methylmercury inhibit neural progenitor cell proliferation associated with up-regulation of glycogen synthase kinase 3β and subsequent degradation of cyclin E in rats
Keywords: کیناز وابسته به سیکلین، CDK; MeHg, methylmercury; NPCs, neural progenitor cells; GSK-3β, glycogen synthase kinase 3β; CDK, cyclin-dependent kinase; MTS, 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl-2H-tetrazolium, inner salt); BrdU, bromodeoxyuridine; NeuN
Arabidopsis thaliana seedlings show an age-dependent response on growth and DNA repair after exposure to chronic γ-radiation
Keywords: کیناز وابسته به سیکلین، CDK; Ionising radiation; Arabidopsis thaliana; Abiotic stress; Biological effects; Gene expressionBER, base excision repair; CDK, cyclin-dependent kinase; DSB, double strand breaks; HR, homologous recombination; IR, ionising radiation; NHEJ, non-homologous end
Aurora Kinase A Is Upregulated in Cutaneous T-Cell Lymphoma and Represents a Potential Therapeutic Target
Keywords: کیناز وابسته به سیکلین، CDK; AURK, Aurora kinase; AURKA, Aurora kinase A; cDNA, complementary DNA; CDK, cyclin-dependent kinase; CTCL, cutaneous T-cell lymphoma; MF, mycosis fungoides; PLK1, polo-like kinase 1; SS, Sézary syndrome
Application of electroretinography (ERG) in early drug development for assessing retinal toxicity in rats
Keywords: کیناز وابسته به سیکلین، CDK; ERG, electroretinography; pan-CDK inhibitor, pan-cyclin dependent kinase inhibitor; CDK, cyclin-dependent kinase; APAP, N-acetyl-para-aminophenol/acetaminophen; Hz, hertz; H&E, hematoxylin and eosin; TUNEL, terminal deoxynucleotide transferase (TdT)-media
microRNA-365-targeted nuclear factor I/B transcriptionally represses cyclin-dependent kinase 6 and 4 to inhibit the progression of cutaneous squamous cell carcinoma
Keywords: کیناز وابسته به سیکلین، CDK; CSCC, cutaneous squamous cell carcinoma; NFIB, nuclear factor I/B; CDK, cyclin-dependent kinase; ChIP, chromatin immunoprecipitation; UV, ultraviolet; p-Rb, phosphorylated retinoblastoma protein; IHC, immunohistochemistrymiR-365; Cutaneous squamous cell c
Resveratrol and pterostilbene regulate MED28 (magicin/EG1) expression and cell growth in MCF7 human breast cancer cells
Keywords: کیناز وابسته به سیکلین، CDK; CDK, cyclin-dependent kinase; DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulfoxide; EG-1, endothelial-derived gene; EGF, epidermal growth factor; ELISA, enzyme-linked immunosorbent assay; ERK, extracellular-signal-regulated kinase; FBS, feta
Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related
Keywords: کیناز وابسته به سیکلین، CDK; ATR, ataxia telangiectasia and Rad3 related; CDC25, cell division cycle 25 phosphatase; Cdk, cyclin-dependent kinase; Chk1, checkpoint kinase 1; DAPI, 4′,6-diamidino-2-phenylindole; DMSO, dimethyl sulfoxide; IDILI, idiosyncratic drug-induced liver injury;
Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells
Keywords: کیناز وابسته به سیکلین، CDK; 4E-BP, eukaryotic initiation factor 4E-binding protein; Akt, Ak thymoma; AML, acute myeloid leukemia; BC-CML, blast crisis-chronic myeloid leukemia; Bcl-2, B-cell lymphoma-2; BCR-ABL, breakpoint cluster region-abelson; CDK, cyclin-dependent kinase; del, d
Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B
Keywords: کیناز وابسته به سیکلین، CDK; 6-4PP, 6-4 photoproduct; BMC, bone marrow cell; Cdk, cyclin-dependent kinase; CPD, cyclopyrimidine dimer; CPT, camptothecin; CRBN, Cereblon; CRL4, cullin RING ligase; CS, Cockayne syndrome; CSN, COP9 signalosome; CUL4A, cullin 4A; CUL4B, cullin 4B; DCAF,
Potential mechanism of mycelium polysaccharide from Pholiota dinghuensis Bi in regulating the proliferation and apoptosis of human breast cancer MCF-7 cells through p38/MAPK pathway
Keywords: کیناز وابسته به سیکلین، CDK; ASK, apoptosis signal regulating kinase; Bcl-2, B cell lymphoma-2; Bax, Bcl-2 associated X protein; Caspase, cysteine aspartic acid specific protease; CDK, cyclin-dependent kinase; DMEM, Dulbecco's Modified Eagle's medium; EDTA, ethylenediaminetetraacetic
Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors
Keywords: کیناز وابسته به سیکلین، CDK; AL, activation loop; ALL, acute lymphoblastic leukemia; AS, activation segment; CDK, cyclin-dependent kinase; Chk, Csk homologous kinase; CML, chronic myelogenous leukemia; Csk, C-terminal Src kinase; C-spine, catalytic spine; EGFR, epidermal growth facto
FAK signaling in human cancer as a target for therapeutics
Keywords: کیناز وابسته به سیکلین، CDK; Tumorigenesis; Metastasis; Tyrosine kinase; Scaffold protein; Tyrosine kinase inhibitor; Cancer stem cellsATP, Adenosine triphosphate; CDK, cyclin-dependent kinase; JNK, c-jun N-terminal kinase; DRT, detergent-resistant membrane; EC, endothelial cell; EGF
Dephosphorylation of Orc2 by protein phosphatase 1 promotes the binding of the origin recognition complex to chromatin
Keywords: کیناز وابسته به سیکلین، CDK; α-pT116, anti-phospho-Thr-116 Orc2 antibody; α-pT226, anti-phospho-Thr-226 Orc2 antibody; CDK, cyclin-dependent kinase; ORC, origin recognition complex; PP1, protein phosphatase 1; PP2A, protein phosphatase 2A; pre-RC, pre-replicative complexORC; Protein
Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo
Keywords: کیناز وابسته به سیکلین، CDK; HNC, head and neck cancers; HNSCC, head and neck squamous cell carcinoma; mTOR, mammalian target of rapamycin; S6K, S6 kinase; CDK, cyclin-dependent kinase; Rb, retinoblastoma proteinGalangin; Head and neck squamous cell carcinoma; Cell cycle; Cyclin D1;
High glucose increases Cdk5 activity in podocytes via transforming growth factor-β1 signaling pathway
Keywords: کیناز وابسته به سیکلین، CDK; Cdk, Cyclin-dependent kinase; DN, Diabetic nephropathy; Egr, Early growth response; ERK, Extracellular signal-regulated kinase; MEK, Mitogen-activated protein kinase/ERK kinase; siRNA, Small interference RNA; TGF-β1, Transforming growth factor-β1.Cdk5; TG
Focal adhesion kinase antagonizes doxorubicin cardiotoxicity via p21Cip1
Keywords: کیناز وابسته به سیکلین، CDK; CDK, cyclin-dependent kinase; CDKI, cyclin-dependent kinase inhibitor; DOX, doxorubicin; FAK, focal adhesion kinase; MFKO, myocyte-restricted FAK knockout mice; NRCMs, neonatal rat cardiomyocytes; NTG, non-transgenic littermate control mice; SF, Super act
Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells
Keywords: کیناز وابسته به سیکلین، CDK; Akt, protein kinase B; ARE, antioxidant response element; Erk, extracellular signal-regulated kinase; CBP, CREB-binding protein; CREB, cAMP response-element (CRE) binding protein; CDK, cyclin-dependent kinase; DHE, dihydroethidium; Drp1, dynamin-related p
CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions
Keywords: کیناز وابسته به سیکلین، CDK; ATRA, all-trans-retinoic acid; CDK, cyclin-dependent kinase; ODN, oligodeoxynucleotide; NCS, neocarzinostatin; ROS, reactive oxygen species; UDS, unscheduled DNA synthesisDNA damage; Neurodegeneration; Learning and memory; Neocarzinostatin; Beta amyloid p
ErbB/HER protein-tyrosine kinases: Structures and small molecule inhibitors
Keywords: کیناز وابسته به سیکلین، CDK; AL, activation loop; AMP-PNP, 5′-adenylyl-β, γ-imidodiphosphate; AS, activation segment; C-spine, catalytic spine; CDK, cyclin-dependent kinase; EC, extracellular; EGFR, epidermal growth factor receptor; FDA, United States Food and Drug Administration; 3-
The ErbB/HER family of protein-tyrosine kinases and cancer
Keywords: کیناز وابسته به سیکلین، CDK; ADCC, antibody-dependent cellular cytotoxicity; ado-trastuzumab emtansine, ado-trastuzumab-DM1; AL, activation loop; AR, amphiregulin; BTC, betacellulin; C-spine, catalytic spine; CAQ, 4-(3-chloroanilino) quinazoline; CDK, cyclin-dependent kinase; CNS, ce
Development of temperature-sensitive mutants of the Drosophila melanogaster P-TEFb (Cyclin T/CDK9) heterodimer using yeast two-hybrid screening
Keywords: کیناز وابسته به سیکلین، CDK; P-TEFb, positive transcription elongation factor b; CDK, cyclin-dependent kinase; TS, temperature sensitive; CS, cold sensitive; Gal4DBD, Gal4 DNA binding domainConditional mutants; Drosophila melanogaster P-TEFb; Cyclin T; CDK9
Cyclin D1/Cdk4 increases the transcriptional activity of FOXM1c without phosphorylating FOXM1c
Keywords: کیناز وابسته به سیکلین، CDK; aa, amino acid; Cdk, cyclin-dependent kinase; CKI, Cdk inhibitor; CMV, cytomegalovirus; DBD, DNA binding domain; dn, dominant-negative; FOXM1c, Forkhead box M1, splice variant c; GST, glutathione-S-transferase; HA, hemagglutinin; HSV, herpes simplex virus
Evidence for reciliation of RPE1 cells in late G1 phase, and ciliary localisation of cyclin B1
Keywords: کیناز وابسته به سیکلین، CDK; Primary cilia; Cyclin B1; CDK1; Aurora A; DNA replication; Cilium disassemblyAurA, Aurora kinase A; BrdU, bromodeoxyuridine; CDK, cyclin-dependent kinase; DAPI, 4’,6-diamidino-2-phenylindole; FBS, fetal bovine serum; HU, hydroxyurea; Mim, mimosine; siRNA,
Stimulatory effect of insulin on theca-interstitial cell proliferation and cell cycle regulatory proteins through MTORC1 dependent pathway
Keywords: کیناز وابسته به سیکلین، CDK; BrdU, Bromodeoxyuridine; CCND3, cyclin D3; CDK, cyclin-dependent kinase; EIF4EBP1, eukaryotic initiation factor 4E binding protein 1; ERK, extracellular signal-regulated kinase; IGF-1, insulin like growth factor 1; MAP kinase, mitogen-activated protein ki
In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells
Keywords: کیناز وابسته به سیکلین، CDK; EGFR, epidermal growth factor receptor; VEGF, vascular endothelial cell growth factor; CDK, cyclin-dependent kinase; CDKI, cyclin-dependant kinase inhibitorPancreatic cancer; Silibinin; Cell cycle; Apoptosis; Angiogenesis
Assessing gene network stability and individual variability in the fathead minnow (Pimephales promelas) transcriptome
Keywords: کیناز وابسته به سیکلین، CDK; CDC45, cell division cycle 45 homolog (S. cerevisiae); CDC6, cell division cycle 6 homolog (S. cerevisiae); CDC7, cell division cycle 7 homolog (S. cerevisiae); CDK, cyclin-dependent kinase; CDT1, chromatin licensing and DNA replication factor 1; CIZ1, CD
Fluorescent biosensors — Probing protein kinase function in cancer and drug discovery
Keywords: کیناز وابسته به سیکلین، CDK; AFP, autofluorescent protein; CDK, cyclin-dependent kinase; CHEF, chelation-enhanced fluorescence; FRET, fluorescence resonance energy transfer; KAR, kinase activity reporter; PAABD, phosphoamino acid binding domain; HCS, high content screening; HTS, high
Luteolin inhibits proliferation of human glioblastoma cells via induction of cell cycle arrest and apoptosis
Keywords: کیناز وابسته به سیکلین، CDK; BCNU, 1,3-bis(2-chloroethyl)-1-nitrosourea; CDK, cyclin-dependent kinase; EA, ethyl acetate; FBS, fetal bovine serum; FITC, annexin-V-fluorescein isothiocyanate; GBM, Glioblastoma multiforme; PARP, poly-ADP-ribose polymerase; PBS, phosphate buffered salin
Rapamycin decreases tau phosphorylation at Ser214 through regulation of cAMP-dependent kinase
Keywords: کیناز وابسته به سیکلین، CDK; AD, Alzheimer’s disease; AKAPs, A kinase-anchored proteins; ANOVA, analysis of variance; CaMK, Ca2+/calmodulin-dependent protein kinase; Cat, catalytic subunits of cAMP-dependent protein kinase; cdk, cyclin-dependent kinase; CK, casein kinase; CREB, cAMP
Camptothecin inhibits platelet-derived growth factor-BB-induced proliferation of rat aortic vascular smooth muscle cells through inhibition of PI3K/Akt signaling pathway
Keywords: کیناز وابسته به سیکلین، CDK; CDK, cyclin-dependent kinase; DMEM, Dulbecco's Modified Eagle's Media; DMSO, dimethyl sulfoxide; ERK, extracellular signal regulated kinase; FBS, fetal bovine serum; HEPES, N-[2-hydroxyethyl]piperazine-N-[2-ethanesulfonicacid]; PBS, phosphate buffered sal
Amadori products promote cellular senescence activating insulin-like growth factor-1 receptor and down-regulating the antioxidant enzyme catalase
Keywords: کیناز وابسته به سیکلین، CDK; CDK, cyclin-dependent kinase; GA, glycated albumin; PKC, protein kinase C; TGF-beta, transforming growth factor-beta; HMC, human mesangial cells; NGA, non-glycated human albumin; CAT, catalase; C12FDG, 5-dodecanoylaminofluorescein di-beta-d-galactopyranos
Synthesis and biological evaluation of guanidino analogues of roscovitine
Keywords: کیناز وابسته به سیکلین، CDK; 6-Guanidinopurine; Olomoucine; Roscovitine; CDK inhibitors; MitosisATP, adenosine 5′-triphosphate; CDK, cyclin-dependent kinase; DABCO, 1,4-diazabicyclo[2.2.2]octane; DMEM, Dulbecco's modified Eagle's medium; DMF, dimethylformamide; DMSO, dimethyl sulfoxi
Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation
Keywords: کیناز وابسته به سیکلین، CDK; ADF, actin-depolymerizing factor; BMP, bone morphogenic protein; BMPRII, BMP receptor II; CaMK, Ca2 +/calmodulin-dependent protein kinase; CaN, calcineurin; Cdk, cyclin-dependent kinase; CIN, chronophin; DSP, dual-specificity phosphatase; D-SSH, Drosophil
Expression of p27Kip1, a cell cycle repressor protein, is inversely associated with potential carcinogenic risk in the genetic rodent models of obesity and long-lived Ames dwarf mice
Keywords: کیناز وابسته به سیکلین، CDK; 4E-BP1, eukaryotic translation initiation factor 4E binding protein 1; AICAR, 5-amino-4-imidazolecarboxamide riboside; AMPK, 5′-AMP-activated protein kinase; CDI, cyclin-dependent kinase inhibitor; CDK, cyclin-dependent kinase; ERK, ERK MAP kinase; GAPDH,
Overlapping activities of TGF-β and Hedgehog signaling in cancer: Therapeutic targets for cancer treatment
Keywords: کیناز وابسته به سیکلین، CDK; ALDH, aldehyde de-hydrogenase; ALK, activin receptor-like kinase; ATO, arsenic tri-oxide; BCC, basal cell carcinoma; BMP, Bone Morphogenetic Protein; CDK, cyclin-dependent kinase; CSC, cancer stem cell; CTL, cytotoxic T-lymphocyte; EMT, epithelial to mese
Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis
Keywords: کیناز وابسته به سیکلین، CDK; 4E-BP1, eIF4E-binding protein 1; AMPK, adenine monophosphate-activated protein kinase; ARE, AU-rich element; BMP, bone morphogenetic protein; CDK, cyclin-dependent kinase; CIN, chromosomal instability; COX, cyclooxygenase; DR, death receptor; EGFR, epider
Design, synthesis and biological evaluation of β-carboline derivatives as novel inhibitors targeting B-Raf kinase
Keywords: کیناز وابسته به سیکلین، CDK; B-Raf kinase inhibitor; β-Carboline derivatives; Kinase inhibitory activitiesMAPK, mitogen-activated protein kinase; IC50, half maximal inhibitory concentration; JAK2, janus kinase 2; CDK, cyclin-dependent kinase