
Design and synthesis of fused bicyclic inhibitors targeting the L5 loop site of centromere-associated protein E
Keywords: DIPEA; N,N-diisopropylethylamine; HATU; hexafluorophosphate O-(7-azabenzotriazol-1-yl)-N,N,Nâ²,Nâ²-tetramethyluronium; PD; pharmacodynamic; CENP-E; Electrostatic potential map (EPM); 2,3-Dihydro-1-benzothiophene 1,1-dioxide derivatives; Anti-cancer agen