دانلود مقالات ISI درباره Chk1، checkpoint kinase 1 + ترجمه فارسی

تعاملات بین هیدروکربن های آروماتیک چند حلقه ای در ترکیبات پیچیده و پیامدهای آن برای ارزیابی خطر سرطان

Interactions between polycyclic aromatic hydrocarbons in complex mixtures and implications for cancer risk assessment

Keywords: Chk1، checkpoint kinase 1; AhR, aryl hydrocarbon receptor; ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia and Rad3-related protein; B[a]P, benzo[a]pyrene; B[a]Peq, B[a]P-equivalent; Chk1, checkpoint kinase 1; CT, coal tar; CYP, cytochrome P450; DE, diol epoxide; DNA

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Lovastatin prevents cisplatin-induced activation of pro-apoptotic DNA damage response (DDR) of renal tubular epithelial cells

Keywords: Chk1، checkpoint kinase 1; ApG, adenine-guanine; ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia and Rad3 related kinase; Bax, Bcl2-associated X protein; Bcl2, B-cell/lymphoma 2; Chk1, checkpoint kinase 1; Chk2, checkpoint kinase 2; CisPt, cisplatin; Ctr1, solute car

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

A novel assay revealed that ribonucleotide reductase is functionally important for interstrand DNA crosslink repair

Keywords: Chk1، checkpoint kinase 1; ATM, Ataxia telangiectasia mutated; ATR, ATM and rad3-related; BCA, bicinchoninic acid; Chk1, checkpoint kinase 1; DDR, DNA damage response/repair; DMSO, dimethyl sulfoxide; EDTA, ethylenediaminetetraacetic acid; FBS, fetal bovine serum; HEPES, 2-[4-(2-hy

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

STAT3 regulated ATR via microRNA-383 to control DNA damage to affect apoptosis in A431 cells

Keywords: Chk1، checkpoint kinase 1; STAT3, signal transducer and activator of transcription 3; 3′ UTR, 3′ untranslated regions; UV, ultraviolet radiation; PIKK, phosphatidylinositol 3-kinase-related kinase; ATM, the ataxia telangiectasia-mutated; ATR, Rad3-related; CHK1, checkpoint kinase 1

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related

Keywords: Chk1، checkpoint kinase 1; ATR, ataxia telangiectasia and Rad3 related; CDC25, cell division cycle 25 phosphatase; Cdk, cyclin-dependent kinase; Chk1, checkpoint kinase 1; DAPI, 4′,6-diamidino-2-phenylindole; DMSO, dimethyl sulfoxide; IDILI, idiosyncratic drug-induced liver injury;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

CHEK again: Revisiting the development of CHK1 inhibitors for cancer therapy

Keywords: Chk1، checkpoint kinase 1; CHK1; Checkpoint kinase 1; DNA replication; WEE1; DNA damage responseATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3 related; CHK1, Checkpoint Kinase 1; CHK2, Checkpoint Kinase 2; CDKs, Cyclin-dependent kinases; DDK, DBF4/DRF1-dependent CDC7 kinase;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Interaction between Rad9–Hus1–Rad1 and TopBP1 activates ATR–ATRIP and promotes TopBP1 recruitment to sites of UV-damage

Keywords: Chk1، checkpoint kinase 1; Rad, radiation sensitive; Hus, hydroxyurea sensitive; 9–1–1, Rad9–Hus1–Rad1; ser, serine; TopBP1, DNA Topoisomerase II Binding Protein 1; CK2, casein kinase 2; ATR, ATM- and Rad3-related; Chk1, checkpoint kinase 1; ATM, Ataxia telangiectasia mutated; ATRI

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Persistent activation of DNA damage signaling in response to complex mixtures of PAHs in air particulate matter

Keywords: Chk1، checkpoint kinase 1; PAH, polycyclic aromatic hydrocarbon; PM, particulate matter; BP, benzo[a]pyrene; DBP, dibenzo[a,l]pyrene; Chk1, checkpoint kinase 1; CYP, cytochrome P450; TEF, toxic equivalency factor; RPF, relative potency factor; SPE, solid phase extraction; DDR, DNA

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Ligand modulation of a dinuclear platinum compound leads to mechanistic differences in cell cycle progression and arrest

Keywords: Chk1، checkpoint kinase 1; ATM, Ataxia Telangiectasia Mutated; ATR, Ataxia Telangiectasia Mutated and Rad3 related; BrdU, bromodeoxyuridine; CDK, cyclin dependent kinase; Chk1, checkpoint kinase 1; DACH, 1,2-diaminocyclohexane; Gy, Gray; MTT, (3,4,5-dimethylthiazol-2-yl)-2,5-diphen

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

MAGE-A antigens as targets in tumour therapy

Keywords: Chk1، checkpoint kinase 1; AR, androgen receptor; ARF, alternative reading frame; CHK1, checkpoint kinase 1; CT, cancer/testis; EBV, epstein-barr virus; EGF, epidermal growth factor; HDAC, histone deacetylase; hNSE1, human non-SMC element 1 homologue (S. cerevisiae); KAP1, (also kn

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Cdk phosphorylation of Chk1 regulates efficient Chk1 activation and multiple checkpoint proficiency

Keywords: Chk1، checkpoint kinase 1; Cdk, cyclin-dependent kinase; ATM, ataxia-telangiectasia mutated; ATR, ATM-and Rad3-related; Chk1, checkpoint kinase 1; UV, ultravioletChk1; Cdk; S/M checkpoint; G2/M checkpoint; Cell cycle

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy

Keywords: Chk1، checkpoint kinase 1; Chk1; Chk1inhibitor; AZD7762; Radiosensitivity; DNA damage checkpointDSB, double-stranded DNA break; Chk1, checkpoint kinase 1; ATM, ataxia-telangiectasia mutated; ATR, ATM and Rad3-related; IR, ionizing radiation; MBT, metastatic brain tumor; shRNA, smal

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

M2, a novel anthracenedione, elicits a potent DNA damage response that can be subverted through checkpoint kinase inhibition to generate mitotic catastrophe

Keywords: Chk1، checkpoint kinase 1; AN-9, pivaloyloxymethyl butyrate; ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia mutated-related; CC, closed; Chk1, checkpoint kinase 1; Chk2, checkpoint kinase 2; CI, combination index; DDR, DNA damage response; DNA-PK, DNA protein kinase

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair

Keywords: Chk1، checkpoint kinase 1; ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia mutated and Rad3-related; CHK1, checkpoint kinase 1; CHK2, checkpoint kinase 2; CPD, cyclobutane pyrimidine dimers; CS, Cockayne's syndrome; DAPI, 4′-6′-diamidino-2-phenylindole; DDB2, damaged

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Crystal Structure of the Human Rad9–Hus1–Rad1 Clamp

Keywords: Chk1، checkpoint kinase 1; EM, electron microscopy; PCNA, proliferating cell nucleus antigen; Chk1, checkpoint kinase 1; RFC, replication factor C; FEN1, flap endonuclease 1; MYH, MutY glycosylase homologue; hMYH, human MYH; IDC, interdomain connecting; SeMet, selenomethionine; Sso

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Apoptotic death induced by the cyclophosphamide analogue mafosfamide in human lymphoblastoid cells: Contribution of DNA replication, transcription inhibition and Chk/p53 signaling

Keywords: Chk1، checkpoint kinase 1; TK6, p53 wild-type lymphoblastoid cells; WTK1, p53 mutant lymphoblastoid cells; ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia and Rad3 related; Chk1, checkpoint kinase 1; Chk2, checkpoint kinase 2; PI3-kinase, phosphoinositide-3 kinase; F

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

RPA Mediates Recombination Repair During Replication Stress and Is Displaced from DNA by Checkpoint Signalling in Human Cells

Keywords: Chk1، checkpoint kinase 1; Chk1, checkpoint kinase 1; DSBs, DNA double-strand breaks; HU, hydroxyurea; MRN, MRE11/RAD50/NBS1; RPA, replication protein A; siRNA, small interfering RNA; TopBP1, topoisomerase IIβ binding protein 1RPA; homologous recombination; Chk1; mammalian cells; s

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Role of Claspin in regulation of nucleotide excision repair factor DDB2

Keywords: Chk1، checkpoint kinase 1; 6-4 PP, (6-4) photoproducts; ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia mutated- and rad-related; Chk1, checkpoint kinase 1; CPD, cyclobutane pyrimidine dimers; Cul4A, cullin 4A E3 ubiquitin ligase; DTT, dithiothreitol; GG-NER, global

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation

Keywords: Chk1، checkpoint kinase 1; ara-C, arabinosylcytosine; ATM, ataxia telangiectasia-mutated; ATR, ataxia telangiectasia-mutated and Rad 3-related; CDC, cell division cycle; CDK, cyclin-dependent kinase; Chk1, checkpoint kinase 1; DMEM, Dulbecco’s modified Eagle’s medium; DMSO, dimethy

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

Excess ribonucleotide reductase R2 subunits coordinate the S phase checkpoint to facilitate DNA damage repair and recovery from replication stress

Keywords: Chk1، checkpoint kinase 1; RNR, ribonucleotide reductase; ATM, ataxia telangiectasia-mutated; ATR, ATM and Rad3-related; DSBs, DNA double-stranded breaks; IR, ionizing radiation; chk1, checkpoint kinase 1; γ-H2Ax, phosphorylated-histone 2Ax; sh/siRNA, short hairpin/short interferen

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

5-ASA Affects Cell Cycle Progression in Colorectal Cells by Reversibly Activating a Replication Checkpoint

Keywords: Chk1، checkpoint kinase 1; 5-ASA, 5-amino-salicylic acid (mesalazine); ATM, ataxia telangiectasia mutated kinase; ATR, ATM-and-Rad3-related kinase; ATRIP, ATR-interacting protein; CDK, cyclin-dependent kinase; Chk1, checkpoint kinase 1; COX, cyclooxygenase; CRC, colorectal cancer;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2007 سفارش ترجمه

The p53 pathway is synergized by p38 MAPK signaling to mediate 11,11′-dideoxyverticillin-induced G2/M arrest

Keywords: Chk1، checkpoint kinase 1; Chk1, checkpoint kinase 1; Chk2, checkpoint kinase 2; p38 MAPK, p38 mitogen-activated protein kinase; DMSO, dimethyl sulfoxide; FBS, fetal bovine serum; PBS, phosphate buffered saline; PI, propidium iodide11,11′-dideoxyverticillin; G2/M arrest; p53; p38 M

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه