Keywords: Blood-borne gene signature; Human hepatocellular carcinoma (HCC); Peripheral blood mononuclear cells (PBMC); Chronic hepatitis B (CHB); Chemokine (C-X-C motif) receptor 2 (CXCR2); C–C chemokine receptor type 2 (CCR2); E1A-Binding Protein P400 (EP400); Mul