Keywords: نامزد بالینی; Neurosteroid; NAS; GABAA; NMDA; Synaptic; Extrasynaptic; Clinical candidate;
مقالات ISI نامزد بالینی (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Discovery of AAT-008, a novel, potent, and selective prostaglandin EP4 receptor antagonist
Keywords: نامزد بالینی; EP4 receptor antagonist; Structure-activity relationship (SAR); Prostaglandin E2; Inflammation; Pain; Autoimmune diseases; Cancer; Clinical candidate;
Recent progress towards clinically relevant ATP-competitive Akt inhibitors
Keywords: نامزد بالینی; Akt inhibitor; Kinase inhibitor; PI3K/Akt/mTOR pathway; Clinical candidate;
The drug candidate, ADX71441, is a novel, potent and selective positive allosteric modulator of the GABAB receptor with a potential for treatment of anxiety, pain and spasticity
Keywords: نامزد بالینی; Allosteric modulator; GABA; Anxiety; Pain; Body temperature; Baclofen; Spasticity; Clinical candidate; GABA (PubChem CID: 119); (R)-Baclofen (PubChem CID: 44602); Diazepam (PubChem CID: 3016); Chlordiazepoxide (PubChem CID: 2712);
Identification and biological activity of 6-alkyl-substituted 3-methyl-pyridine-2-carbonyl amino dimethyl-benzoic acid EP4 antagonists
Keywords: نامزد بالینی; Prostaglandin E2 (PGE2); EP4 antagonist; Clinical candidate; Pain; Inflammation
Discovery of an l-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100
Keywords: نامزد بالینی; Prodrugs; Hsp90 inhibitors; Salt screening; Clinical candidate; Chromatography-free synthesis;
Identification of clinical candidates from the benzazepine class of histamine H3 receptor antagonists
Keywords: نامزد بالینی; H3 receptor; Histamine; GPCR; Clinical candidate; Receptor antagonists; Neurotransmitters; Lead optimisation;
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation
Keywords: نامزد بالینی; Inflammation; m-PGES-1; Benzoxazole; Clinical candidate; PF-4693627
Small molecule inhibitors of BRAF in clinical trials
Keywords: نامزد بالینی; Kinase inhibitor; BRAF protein; Clinical candidate;
Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4â²-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)
Keywords: نامزد بالینی; Histamine-H3 antagonist; Sleep; Wakefulness; CNS; hERG; Clinical candidate;
Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development
Keywords: نامزد بالینی; mGluR5; Negative allosteric modulator; GPCR; In vitro pharmacology; Pain; Clinical candidate;
Design, synthesis and structure–activity relationships of (indo-3-yl) heterocyclic derivatives as agonists of the CB1 receptor. Discovery of a clinical candidate
Keywords: نامزد بالینی; Cannabinoid; CB1 receptor agonist; GPCR; Clinical candidate
Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: A novel histamine H4 receptor antagonist
Keywords: نامزد بالینی; Histamine; H4 receptor; GPCR antagonist; Toxicity studies; Clinical candidate; Biomarker; PF-3893787
The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: The first clinical candidate
Keywords: نامزد بالینی; Cyclooxygenase; COX-2 inhibitor; Clinical candidate; Benzopyran; Half-life; Plasma protein bound; X-ray crystal structure
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: The three microdose candidates
Keywords: نامزد بالینی; Cyclooxygenase; Clinical candidate; Benzopyran; Half-life; Plasma protein bound; Microdose; Microsomal; Metabolism
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life
Keywords: نامزد بالینی; Cyclooxygenase; COX-2 inhibitor; Clinical candidate; Benzopyran; Half-life; Plasma protein bound; Microsomal; X-ray crystal structure
The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA α5 inverse agonists for the treatment of cognitive dysfunction
Keywords: نامزد بالینی; Neuroscience; GABAA receptor subtypes; Lead optimisation; Clinical candidate
Structure–activity relationships of triazolopyridine oxazole p38 inhibitors: Identification of candidates for clinical development
Keywords: نامزد بالینی; p38 kinase; MAP, mitogen activated protein; Inhibitor; SAR, structure–activity relationship; Clinical candidate; Triazolopyridine; Oxazole; Triazole; TNF-α, tumor necrosis factor-α; CP-808844; Inflammation; Arthritis; Cytokine; Anti-inflammatory