Keywords: کلینت; AIDS; acquired immunodeficiency syndrome; AUC; area under the plasma concentration versus time curve of NVP in absence of NT; AUCI; area under the plasma concentration versus time curve of NVP in presence of NT; AUCratio; ratio between AUCI and AUC (AUCI/
مقالات ISI کلینت (ترجمه نشده)
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Keywords: کلینت; CLint; Intrinsic hepatic clearance; HLM; Human liver microsomes; LC/MS/MS; Liquid chromatography tandem mass spectrometry; LC/UV/RAD; Liquid chromatography/ultraviolet/radioactive detection; MRM; Multiple reaction monitoring; NADPH; Nicotinamide adenine d
Keywords: کلینت; AUC; area under the concentration-time curve; BN; benalaxyl; CE; capillary electromigration techniques; CL; clearance; CLH; hepatic clearance; CLint; intrinsic clearance; DC; diclofop; DM; diclofop-methyl; DN; diniconazole; E; hepatic extraction rate; ET;
Keywords: کلینت; ADAM; advanced dissolution, absorption, and metabolism; AED; antiepileptic drug; AUC; area-under-the-curve; B/P; blood to plasma ratio; BID; twice daily; BMI; body mass index; CBZ; carbamazepine; CLint; intrinsic clearance; CLR; renal clearance; CL; clear
Keywords: کلینت; ADME; absorption distribution metabolism excretion; AFE; average fold error; CLint; intrinsic metabolic clearance; CRO; contract research organisation; CYP; cytochrome P450; DMPK; drug metabolism and pharmacokinetics; G6P; glucose-6-phosphate; t1/2; half-
Keywords: کلینت; Clint; intrinsic clearance; Clint app.; apparent intrinsic clearance; DAD; diod array detector; DMSO; dimethyl sulfoxide; ER; endoplasmic reticulum; fu; unbound fraction of a drug in the microsomal incubation mixture; HPLC; high performance liquid chromat
Keywords: کلینت; EPA; Environmental Protection Agency; HTS; High-Throughput Screening; IVIVE; in vivo-in vitro extrapolation; OED; Oral equivalent dose; AER; Activity:Exposure ratio; TK; Toxicokinetics; HTTK; High Throughput TK; NHANES; National Health and Nutrition Exami
Keywords: کلینت; preclinical pharmacokinetics; physiological model; simulations; clearance; absorption; distribution; ADAM; advanced dissolution absorption and metabolism; B:P; blood-to-plasma ratio; CLint; intrinsic clearance; CLiv; intravenous clearance; CLu,intH; unbou
Keywords: کلینت; AUC; area under the plasma concentration-time curve; B/P; blood-to-plasma ratio; CYP; cytochrome P450; CLint; intrinsic clearance; Cmax; maximum plasma concentration; CLPD; passive permeability-surface area product; DDI; drug-drug interaction; fa; fract
Keywords: کلینت; 3-PBA; 3-phenoxybenzoic acid; 3-PBAlc; 3-phenoxy-benzylalcohol; 8-OhdG; 8-hydroxy-2â²-deoxyguanosine; AchE; acetylcholinesterase; ADH; alcohol dehydrogenase; ALDH; aldehyde dehydrogenase; ANT; anthracene; ARE; antioxidant response element; AUC; area unde
Keywords: کلینت; AKR; aldo-keto reductase; CBZ-E; carbamazepine 10,11-epoxide; Cmax; mean maximum level; CLint; internal clearance; DHD; 10,11-dihydro-10,11-dihydroxy-carbamazepine; MHD; 10,11-dihydro-10-hydroxy-carbamazepine; SDR; short-chain dehydrogenase/reductase; O
Keywords: کلینت; ADH; alcohol dehydrogenase; BSA; body surface area; BH; body height; BW; body weight; Clint; intrinsic clearance; Clintad; intrinsic clearance in average adult; Clintind; intrinsic clearance in any individual; CAss; arterial blood concentration at steady-
Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography
Keywords: کلینت; 75Se-SeHCAT; 75Se-labelled homocholic acid taurine; PET; positron emission tomography; 11C-CSar; [N-methyl-11C]cholylsarcosine; CT; computed tomography; PSmem; permeability surface area product for 11C-CSar from blood to hepatocytes; Clint; hepatic intrin
Development of human biotransformation QSARs and application for PBT assessment refinement
Keywords: کلینت; In vivo biotransformation; Biotransformation half-life; QSAR; Hazard assessment; Refined PBT assessment; 1-CoPK; one-compartment pharmacokinetic model; AD; Applicability Domain; ADME; Absorption, Distribution, Metabolism and Elimination; B; Bioaccumulati
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria
Keywords: کلینت; AUC; area under the curve; BA; bioavailability; CLplasma; plasma clearance; CLint; intrinsic clearance; CYP; cytochrome P450; DCM; dichloromethane; DMF; dimethyl formamide; ED; effective dose; FaSSIF; fasted state simulated intestinal fluid; FeSSIF; fed s
Sulfation disposition of liquiritigenin in SULT1A3 overexpressing HEK293 cells: The role of breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 4 (MRP4) in sulfate efflux of liquiritigenin
Keywords: کلینت; CLint; intrinsic clearance; CYP; cytochrome P450; HPLC; high performance liquid chromatography; Km; Michaelis-Menten constant; MS; mass spectroscopy; PAPS; 3â²-Phosphoadenosine-5â²-phosphosulfate; QTOF; Quadrupole time-of-flight; shRNA; short hairpin RN
Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis
Keywords: کلینت; CE; capillary electrophoresis; Clint; intrinsic clearance; CLM; canine liver microsomes; CYP; cytochrome P450 enzymes; D; diazepam; DHNK; 5,6-dehydronorketamine; ELM; equine liver microsomes; HLM; human liver microsomes; HNK; hydroxynorketamine; IST; inte
Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes
Keywords: کلینت; Bile canaliculi; Collagen; Hepatic drug disposition; Methods; Sandwich-cultured rat hepatocytes; AUC; Area Under the Curve; BEI; biliary excretion index; CDF; 5-(6)-carboxy-2-dichlorofluorescein; CDFDA; 5-(6)-carboxy-2-dichlorofluorescein diacetate; Clint
Effect of genetic polymorphism on the inhibition of dopamine formation from p-tyramine catalyzed by brain cytochrome P450 2D6
Keywords: کلینت; CYP2D6; Dopamine formation; Genetic polymorphism; Drug interaction; CLint; intrinsic clearance; CYP or P450; cytochrome P450; DHEA; dehydroepiandrosterone; IC50; 50% inhibitory concentration; Iu; unbound concentration of the inhibitor; Ki; inhibitory cons
Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes
Keywords: کلینت; ADME; absorption, distribution, metabolism and excretion; Clint; intrinsic clearance; Clp; plasma clearance; Clu; unbound clearance; DCM; dichloromethane; DHEP; dog hepatocytes; DLM; dog liver microsomes; DMAc; dimethylacetamide; DMF; dimethylformamide; D
Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates
Keywords: کلینت; CYP3A4; NADPH-cytochrome P450 reductase; Caco-2Â cells; Human artificial chromosome vector; Intestinal metabolism; ABT; 1-aminobenzotriazole; CLint; intrinsic clearance; CPR; NADPH-cytochrome P450 reductase; Ct; threshold cycle; CYP; cytochrome P450; Eg;
Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids
Keywords: کلینت; AUDA; 212-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid; 4-HBP; 4-hydroxybenzophenone; ACN; acetonitrile; CLother(AA); aggregate clearance of other pathways of AA; CLother(EET); aggregate clearance of other pathways of EET; AA; arac
Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data
Keywords: کلینت; clinical trial simulations; drug interactions; pharmacokinetics; physiologically based pharmacokinetic modeling; organic anion-transporting polypeptide transporters; CYP enzymes; AUC; area under the blood concentration-time curve; AUCR; area under the b
Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations
Keywords: کلینت; active transport; passive diffusion/transport; hepatic metabolism; biliary excretion; distribution; disposition; tissue partition; protein binding; hepatocytes; human liver microsomes; ABT; 1-aminobenzotriazole; AFE; average fold error; CLint; intrinsic c
Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of ursolic acid
Keywords: کلینت; Ursolic acid; UDP-glucuronosyltransferases; Metabolism pathway; Metabolism characterization; UA; ursolic acid; HLMs; human liver microsomes; HIMs; human intestinal microsomes; UGTs; UDP-glucuronosyltransferases; DDI; drug-drug interactions; RILD; Resear
Tissue and species differences in the glucuronidation of glabridin with UDP-glucuronosyltransferases
Keywords: کلینت; GA; glabridin; UGT; UDP-glucuronosyltransferases; HLM and HIM; liver and intestinal microsomes from humans, respectively; RLM and RIM; liver and intestinal microsomes from rats, respectively; CyLM and DLM; liver microsomes from cynomolgus monkeys and beag
In vitro disposition profiling of heterocyclic compounds
Keywords: کلینت; ABT; 1-aminobenzotriazole; ADMET; absorption distribution metabolism excretion toxicity; BCS; biopharmaceutics classification system; BDDCS; biopharmaceutics drug disposition classification system; Clint,basolateral; intrinsic basolateral clearance; Clint
Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling
Keywords: کلینت; AUC; area under the plasma concentration-time curve; DDI; drug-drug interaction; CLint; intrinsic clearance; BCRP; Breast Cancer Resistance Protein; HEK293; Human Embryonic Kidney 293 (cell-line); MRP; Multidrug resistance-associated protein; NTCP; Sodi
Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase
Keywords: کلینت; SDR; short-chain dehydrogenyse/reductase; AKR; aldo-keto reductase; 11β-HSD1; 11β-hydroxysteroid dehydrogenase 1; ANT; anthracycline; DAUN; daunorubicin; DAUNOL; daunorubicinol; ADAUN; aglycone of daunorubicin; ADAUNOL; aglycone of daunorubicinol; DOX;
Synthesis, biological evaluation, and metabolic stability of acrylamide derivatives as novel CCR3 antagonists
Keywords: کلینت; Allergic diseases; CCR3 antagonists; Acrylamide derivatives; CLint