دانلود مقالات ISI درباره CLint، ترخیص داخلی + ترجمه فارسی

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Aspartic protease inhibitors containing tertiary alcohol transition-state mimics

Keywords: CLint، ترخیص داخلی; Protease inhibitors; Tertiary alcohol; Transition-state mimic; HIV; Malaria; AlzheimerAIDS, acquired immune deficiency syndrome; AD, Alzheimer's disease; Aβ, amyloid beta; AP, aspartic protease; Asp, aspartic acid; Clint, intrinsic clearance; CC50, 50% of

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2015 سفارش ترجمه

New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data

Keywords: CLint، ترخیص داخلی; AFE, average fold error; CLh, hepatic clearance; CLint, intrinsic clearance; CLint,h, intrinsic hepatic clearance; CLint,met, intrinsic metabolic clearance; CLint,sec, intrinsic secretory clearance; CLren, renal clearance; CLtot, total clearance; CYP, cyt

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Characterization of in vitro primary metabolic profile of SKLB-M8, a novel antitumor compound, using liquid chromatography coupled with triple quadrupole tandem mass spectrometry and quadrupole time-of-flight tandem mass spectrometry

Keywords: CLint، ترخیص داخلی; CID, collision-induced dissociation; CLint, intrinsic clearance; DLMs, dog liver microsomes; ESI, electrospray ionization; h, Hill coefficient; HLMs, human liver microsomes; IC50, half maximal inhibitory concentration; IS, internal standard; M1-4, metabol

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis, structure–property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor

Keywords: CLint، ترخیص داخلی; P2Y12 receptor; Anti-platelet; Sulfonylureas; Solubility; Stability3-aze, 3-amino-azetidinyl; CDI, N,N′-carbonyl diimidazole; CLint, intrinsic clearance; cy-Pr, cyclopropyl; Caco-2, adenocarcinoma cells from human colon; DIPEA, N,N-diisopropylethylamine;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Muscle contraction increases carnitine uptake via translocation of OCTN2

Keywords: CLint، ترخیص داخلی; CLint, Intrinsic clearance; CLuptake, Uptake clearance; GAPDH, Glyceraldehyde-3-phosphate dehydrogenase; GasD, The deep portions of muscle gastrocnemius; GasS, The surface portions of muscle gastrocnemius; IAP, Iodoantipyrine; MCT4, Monocarboxylate transp

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Optimization of the HepaRG cell model for drug metabolism and toxicity studies

Keywords: CLint، ترخیص داخلی; ADMET, absorption, distribution, metabolism, excretion and/or toxicity; AFB1, aflatoxin B1; CLint, intrinsic clearance; CYP, cytochrome P450; DMSO, dimethyl sulfoxide; LD, low density; HD, high density; MeiQx, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

In vitro biotransformation and investigation of metabolic enzymes possibly responsible for the metabolism of bisdesoxyolaquindox in the liver fractions of rats, chicken, and pigs

Keywords: CLint، ترخیص داخلی; ADH, alcohol dehydrogenase; ALDH, aldehyde dehydrogenase; ANF, α-naphthoflavon; AO, aldehyde oxidase; BDES, bisdesoxyolaquindox; CID, collision-induced dissociation; Clint, intrinsic clearance; CPZ, chlorpromazine; CYP, cytochrome P450; DDTC, diethyldithi

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Prediction of pharmacokinetic drug–drug interaction caused by changes in cytochrome P450 activity using in vivo information

Keywords: CLint، ترخیص داخلی; AUC, area under the plasma or serum drug concentration curve; CLint, intrinsic clearance; CLint,g, intrinsic clearance of enterocytes; CR, contribution ratio of the clearance pathway to clearance after oral absorption; CRh, contribution ratio of hepatic c

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2010 سفارش ترجمه

In vitro measurements of metabolism for application in pharmacokinetic modeling

Keywords: CLint، ترخیص داخلی; AUC, area under the curve; BW, body weight; CLh, hepatic clearance; CLint, intrinsic clearance; CYP, cytochrome P450; DDI, drug–drug interaction; DZN, diazinon; Fu-inc, fraction of unbound drug in incubation; Fu-bl, fraction of unbound drug in blood; FCZ,

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2008 سفارش ترجمه

High performance liquid chromatography with ultraviolet detection for the determination of SYUIQ-5, a novel telomerase inhibitor for cancer therapy: Application to an enzyme kinetic study in rat liver microsomes

Keywords: CLint، ترخیص داخلی; CLint, intrinsic clearance; CV, coefficient of variation; CYP, cytochrome P450; Km, Michaelis–Menten constant; LOQ, lower limit of quantification; NADPH, reduced β-nicotinamide adenine dinucleotide phosphate; Vmax, maximum velocity of reactionSYUIQ-5; HPL

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Glucuronidation of fenamates: Kinetic studies using human kidney cortical microsomes and recombinant UDP-glucuronosyltransferase (UGT) 1A9 and 2B7

Keywords: CLint، ترخیص داخلی; 4-MU, 4-methylumbelliferone; CLint, intrinsic clearance; h, Hill coefficient; HKCM, human kidney cortical microsomes; IC50, concentration of inhibitor causing 50% inhibition; Kmapp, apparent Michaelis constant; MM, Michaelis–Menten; NSAIDs, non-steroidal

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Effects of renal failure on drug transport and metabolism

Keywords: CLint، ترخیص داخلی; Renal failure; Uptake transporters; Efflux transporters; Hepatic clearance; Uremic toxinsAUC, area under the curve; CLint, intrinsic clearance; CMPF, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid; CRF, chronic renal failure; CYP450, cytochrome P450; E

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: Drug–drug interactions and interindividual differences in transporter and metabolic enzyme functions

Keywords: CLint، ترخیص داخلی; AUC, area under the plasma concentration–time profile; BCRP/Bcrp, breast cancer resistance protein; BSEP/Bsep, bile salt exporting pump; CLint, intrinsic clearance; CLint,all, overall intrinsic clearance; CLtot, total body clearance; Cmax, maximum plasma

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2006 سفارش ترجمه