
Recombinant human tripeptidyl peptidase-1 infusion to the monkey CNS: Safety, pharmacokinetics, and distribution
Keywords: aCSF, artificial cerebrospinal fluid; AUC, area under the curve; CHO, Chinese hamster ovary; CLN2, ceroid lipofuscinosis neuronal type 2; Cmax, maximal concentration; CRIM, cross-reactive immunological material; D, deep tissue; ERT, enzyme replacement the