Linking HSP90 target occupancy to HSP70 induction and efficacy in mouse brain
Keywords: 17-AAG; 17-Allylamino-17-demethoxygeldanamycin; Cmpd; compound; CNS; central nervous system; fEPSP; evoked postsynaptic field potential; HSF1; heat-shock factor 1; HSP; heat-shock protein; Occ50; 50% occupancy; p.o.; peroral dosing; HSP70; HSP90; Occupanc