Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties
Keywords: Hybrid drugs; Oxidative stress; Combretastatin-A4; Protein glutathionylation; Cancer chemotherapyROS, reactive oxygen species; GSH, glutathione; CA4, combretastatin A4; PL, piperlongumine; wt, wild-type; DCF-DA, 2′,7′-dichlorofluorescein diacetate; KSS-9,