Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies
Keywords: Isothiazoles; Dihydroisothiazolopyridinones; Microtubule destabilization; Sea urchin embryo; Cytotoxicity; CA4P; combretastatin A-4 disodium phosphate; DIP; 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones; MDR; multi-drug resistance; Pgp; P-glycoprotein;