Keywords: کنوتوکسین; Calcium channels; Conotoxin; Agatoxin; Protoxin; Spiders; Venom; Pain;
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Keywords: کنوتوکسین; MeCN; acetonitrile; MS; mass spectrometry; TFA; trifluoroacetic acid; Prohormone-4; Elevenin; Conotoxin; Venom; Neuropeptide; Hormone;
Keywords: کنوتوکسین; Unedogemmula bisaya; Crassispira cerithina; Gemmula speciosa; Turritoxin; Conotoxin; Venom duct;
Keywords: کنوتوکسین; Conotoxin; Crassipeptide; Crassispirine snails; Potassium channel; cce9a; cce9b
Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB
Keywords: کنوتوکسین; ACh; acetylcholine; AChBP; acetylcholine-binding protein; ECD; extracellular domain; gAuIB; globular AuIB; ICD; intracellular domain; nAChR; nicotinic acetylcholine receptor; rAuIB; ribbon AuIB; SAR; structure-activity relationship; TMD; transmembrane dom
α-Conotoxins to explore the molecular, physiological and pathophysiological functions of neuronal nicotinic acetylcholine receptors
Keywords: کنوتوکسین; Nicotinic acetylcholine receptor; Venom; Cone snail; Conotoxin;
A novel μ-conotoxin from worm-hunting Conus tessulatus that selectively inhibit rat TTX-resistant sodium currents
Keywords: کنوتوکسین; Conotoxin; Conopeptide; Voltage-gated sodium channels; Pain;
Structure and activity of contryphan-Vc2: Importance of the d-amino acid residue
Keywords: کنوتوکسین; Conotoxin; Contryphan-Vc2; Nuclear magnetic resonance; Solution structure; Molecular dynamics; d-amino acid; BMRB; Biological Magnetic Resonance Data Bank; BSA; bovine serum albumin; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; DPC; dodec
Research PaperCisplatin-induced neuropathic pain is mediated by upregulation of N-type voltage-gated calcium channels in dorsal root ganglion neurons
Keywords: کنوتوکسین; Neuropathic pain; Polyneuropathy; Cisplatin; Voltage-gated calcium channels; Dorsal root ganglion; Conotoxin;
Subtype-specific block of voltage-gated K+ channels by μ-conopeptides
Keywords: کنوتوکسین; Channel block; Pain; Patch clamp; Cone snails; Conotoxin; Neurotoxin; TTX; tetrodotoxin; KV channel; Voltage-gated K+ channel; NaV channel; Voltage-gated Na+ channel;
Molecular interaction of δ-conopeptide EVIA with voltage-gated Na+ channels
Keywords: کنوتوکسین; COSY; correlation spectroscopy; DG; distance geometry; DIEA; N,N-diisopropylethylamine; Fmoc; 9-fluorenylmethoxycarbonyl; GSH; glutathione reduced; GSSG; glutathione oxidized; HBTU; O-(benzotriazol-1-yl)-N,N,Nâ²,Nâ²-tetramethyl-uronium-hexafluorophospha
Soluble expression and sodium channel activity of lt16a, a novel framework XVI conotoxin from the M-superfamily
Keywords: کنوتوکسین; Conotoxin; Conopeptide; M-superfamily; Conus litteratus; Sodium currents;
αS-conotoxin GVIIIB potently and selectively blocks α9α10 nicotinic acetylcholine receptors
Keywords: کنوتوکسین; nAChR, nicotinic acetylcholine receptor; ACh, acetylcholine; HPLC, high performance liquid chromatography; SEC, size-exclusion chromatography; TFA, trifluoroacetic acid.Protein purification; Oocyte; Nicotinic receptor; Alpha9 alpha10; Conotoxin
A sleep-inducing peptide from the venom of the Indian cone snail Conus araneosus
Keywords: کنوتوکسین; Conus araneosus; Conotoxin; M-, T-superfamily; Mass spectrometry; Post-translational modification; Sleep-inducing peptide; TCEP; Tris (2-carboxyethyl) phosphine; NEM; N-ethylmaleimide; ACN; acetonitrile; RP-HPLC; reverse phase-high performance liquid chro
Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom
Keywords: کنوتوکسین; ASIC; acid-sensing ion channel; CNF; conorfamide; C-terminus; carboxyl terminus; [Ca2Â +]i; cytosolic calcium ion concentration; DRG; dorsal root ganglion; FaNaC; FMRF-amide-gated Na+ channel; GPCR; G-protein-coupled receptor; IC; intracranial; MeCN; acet
Pharmacological characterization of conotoxin lt14a as a potent non-addictive analgesic
Keywords: کنوتوکسین; Conotoxin; Lt14a; Analgesic; nAChR; Drug addictionnAChR, nicotinic acetylcholine receptor; TUB, tubocurarine chloride; HB, hexamethonium bromide; ERK, extracellular signal-regulated kinase; Ach, acetylcholine; NMR, nuclear magnetic resonance; PWT, paw wit
Soluble expression, purification and functional identification of the framework XV conotoxins derived from different Conus species
Keywords: کنوتوکسین; Bio-activity; Conotoxin; Cysteine framework; Diversity; Recombinant expression
Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose
Keywords: کنوتوکسین; Venom; Cone snails; Conotoxin; Lethal dose; Milking
De novo design and synthesis of a μ-conotoxin KIIIA peptidomimetic
Keywords: کنوتوکسین; Conotoxin; Peptidomimetic; Sodium channel blocker; KIIIA; Pain;
Characterizing the evolution and functions of the M-superfamily conotoxins
Keywords: کنوتوکسین; Conus; Conotoxin; Conopeptide; Birth-and-death evolution; Codon conservation; Insertions and deletions; BEB; Bayes Empirical Bayes; bps; base pairs; EP; eastern Pacific; indels; insertions and deletions; IP; Indo-Pacific; UTR; Untranslated Regions;
Precursor De13.1 from Conus delessertii defines the novel G gene superfamily
Keywords: کنوتوکسین; Conidae; Conopeptide; Conotoxin; Conus delessertii; Hydroxy-lysine; Peptide de13b
A novel arrangement of Cys residues in a paralytic peptide of Conus cancellatus (jr. syn.: Conus austini), a worm-hunting snail from the Gulf of Mexico
Keywords: کنوتوکسین; Conus cancellatus; Conus austini; Vermivorous; Conotoxin; Six Cys; Paralysis
Unraveling the peptidome of the South African cone snails Conus pictus and Conus natalis
Keywords: کنوتوکسین; Conus pictus; Conus natalis; Cone snail; Conotoxin; A-, M-, O-superfamily
Challenging the catechism of therapeutics for chronic neuropathic pain: Targeting CaV2.2 interactions with CRMP2 peptides
Keywords: کنوتوکسین; CGRP; calcitonin gene related peptide; CaV2.2; N-type voltage-gated Ca2+ channel; CBD; Ca2+ channel binding domain; CRMP2; collapsin response mediator protein 2; CPP; cell penetrating peptide; CNS; central nervous system; Ï-CTX; omega-conotoxin; DIV; day
Identification and classification of conopeptides using profile Hidden Markov Models
Keywords: کنوتوکسین; Conotoxin; Conopeptide; Hidden Markov Model; Conopeptide superfamilies; Protein prediction;
Expression of a biologically-active conotoxin PrIIIE in Escherichia coli
Keywords: کنوتوکسین; Conotoxin; Escherichia coli; Acetylcholine receptor;
Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain
Keywords: کنوتوکسین; Conotoxin; Pain; Nicotinic; nAChR; Allodynia; IntrathecalAUC, area under curve; eEPSC, evoked excitatory post-synaptic current; nAChR, nicotinic acetylcholine receptor; PNL, partial nerve ligation; PWT, paw withdrawal threshold
Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity
Keywords: کنوتوکسین; Conotoxin; Conus pictus; Disulfide connectivity; NMR; Electrophysiology; Bioassay;
Recombinant expression and insecticidal properties of a Conus ventricosus conotoxin-GST fusion protein
Keywords: کنوتوکسین; Conotoxins; Ion channels; Recombinant expression; Conus ventricosus; GST; glutathione-S-transferase; CTX; conotoxin;
Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptome
Keywords: کنوتوکسین; Conotoxin; Conopeptide; Toxin; Transcriptome
A novel conotoxin, qc16a, with a unique cysteine framework and folding
Keywords: کنوتوکسین; Conotoxin; Conus quercinus; Disulfide connectivity; Mutation; NMR; Electrophysiology
A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain
Keywords: کنوتوکسین; Conotoxin; GABAB receptor; Nicotinic acetylcholine receptor; N-type Ca2+ channel; Sensory neuron; Mechanical allodynia; Neuropathic pain;
Diselenium, instead of disulfide, bonded analogs of conotoxins: novel synthesis and pharmacotherapeutic potential
Keywords: کنوتوکسین; Cone snail; Conotoxin; Diselenide; Disulfide
Voltage-gated calcium channels involved in the inhibitory motor responses and vasoactive intestinal polypeptide release in the rat gastric fundus
Keywords: کنوتوکسین; NANC (non-adrenergic non-cholinergic) relaxation; Rat gastric fundus; VGCCs (voltage-gated calcium channels); VIP (vasoactive intestinal polypeptide) release; Conotoxin; Agatoxin
Conopeptide characterization and classifications: An analysis using ConoServer
Keywords: کنوتوکسین; Conus venom; Conopeptide; Conotoxin; ConoServer; Cone snail venom
New conotoxins define the novel I3-superfamily
Keywords: کنوتوکسین; Conotoxin; I-superfamily; cDNA cloning;
Role of voltage-gated calcium channels in ascending pain pathways
Keywords: کنوتوکسین; Dorsal root ganglion; T-type channel; N-type channel; Conotoxin; Burst firing
Structural basis for α-conotoxin potency and selectivity
Keywords: کنوتوکسین; NMR solution structure; Conotoxin; Parkinson’s disease; Nicotinic acetylcholine receptorNMR, nuclear magnetic resonance; nAChR, nicotinic acetylcholine receptor; AChBP, acetylcholine binding protein; DA, dopamine; CTx, conotoxin; DQF-COSY, double quantum
Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS
Keywords: کنوتوکسین; Venom peptide; Venomics; Mass spectrometry; Cone snail; Conotoxin
TxXIIIA, an atypical homodimeric conotoxin found in the Conus textile venom
Keywords: کنوتوکسین; Conotoxin; Homodimer; Conus textile; MALDI-TOF/TOF;
Comparative proteomic study of the venom of the piscivorous cone snail Conus consors
Keywords: کنوتوکسین; Cone snail; Conopeptide; Conotoxin; Conus consors; ESI-MS; HPLC; Hydrophobicity; MALDI-TOF-MS; Mass fingerprint; Mass range; Mass spectrometry; Peptide; Peptidomics; Proteomics; Toxins; Venom; Venomics;
ω-Conotoxin GVIA mimetics based on an anthranilamide core: Effect of variation in ammonium side chain lengths and incorporation of fluorine
Keywords: کنوتوکسین; Conotoxin; N-type calcium channels; Cav2.2; Channel blockers; Pain
Use of lantibiotic synthetases for the preparation of bioactive constrained peptides
Keywords: کنوتوکسین; Cyclic peptides; Enkephalin; Conotoxin; Lantibiotic; Dehydroalanine
Isolation and cloning of a conotoxin with a novel cysteine pattern from Conus caracteristicus
Keywords: کنوتوکسین; Conotoxin; Cysteine framework; Signal peptide;
The three-dimensional structure of the analgesic α-conotoxin, RgIA
Keywords: کنوتوکسین; Conotoxin; Nuclear magnetic resonance; Analgesic; Oxidative folding; Disulfide isomers
Identification of a novel class of conotoxins defined as V-conotoxins with a unique cysteine pattern and signal peptide sequence
Keywords: کنوتوکسین; Conotoxin; V-superfamily; Cysteine framework; Diversity
Purification and characterization of a novel excitatory peptide from Conus distans venom that defines a novel gene superfamily of conotoxins
Keywords: کنوتوکسین; Conus venom; Conus peptide; Conotoxin; γ-Carboxyglutamate; Hydroxyproline; Conus distans
Two different groups of signal sequence in M-superfamily conotoxins
Keywords: کنوتوکسین; Conotoxin; M-superfamily; cDNA cloning; Signal peptide; Sequence alignment; Phylogenetic analysisRACE, rapid amplification cDNA ends; AP, adapter primer; AUAP, abridged universal amplification primer; X-Gal, 5-bromo-4-chloro-3-indolyl-β-d-galactopyranosid
I1-superfamily conotoxins and prediction of single d-amino acid occurrence
Keywords: کنوتوکسین; Conotoxin; Epimerization; d-amino acid; Post-translational modifications; Excitatory peptide;
I-conotoxins in vermivorous species of the West Atlantic: Peptide sr11a from Conus spurius
Keywords: کنوتوکسین; Conidae; Cone snail; Western Atlantic; Conus spurius; Conotoxin; I-conotoxin