Keywords: CPP، پپتید نفوذی سلولی; Peptoid; Molecular transporter; Spermine; Cellular uptake; HeLa cellBoc, tert-butoxycarbonyl; CPP, cell-penetrating peptide; CPPo, cell-penetrating peptoid; CuAAC, copper(I)-catalyzed azide-alkyne cycloaddition; DIC, N,N′-diisopropylcarbodiimide; DMF, N,N
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miRNAs in pancreatic cancer: Therapeutic potential, delivery challenges and strategies
Keywords: CPP، پپتید نفوذی سلولی; Ago, Argonaute; ASO, Antisense oligonucleotide; bFGF, Basic fibroblast growth factor; CPP, Cell-penetrating peptide; CSCs, Cancer stem cells; cRGD, Cyclo Arg-Gly-Asp; DNA, Deoxyribonucleic acid; ECM, Extracellular matrix; EGFR, Epidermal growth factor rec
X-pep, a novel cell-penetrating peptide motif derived from the hepatitis B virus
Keywords: CPP، پپتید نفوذی سلولی; aa, amino acid; CPP, cell-penetrating peptide; HBV, hepatitis B virusCell-penetrating peptide; Stereoisomer; Cell-permeability; X-protein; Hepatitis B virus
A novel cell-penetrating peptide derived from WT1 enhances p53 activity, induces cell senescence and displays antimelanoma activity in xeno- and syngeneic systems
Keywords: CPP، پپتید نفوذی سلولی; Malignant melanoma; Wilms tumor 1 (WT1); Senescence; p53C PEP, control peptide; CL-ELISA, chemiluminescence ELISA; CPP, cell-penetrating peptide; pTj, Trojan peptide; SA-βGal, senescence-associated β-galactosidase; TMZ, Temozolomide; WT1, Wilms tumor prot
Identification and characterization of a novel cell-penetrating peptide of 30Kc19 protein derived from Bombyx mori
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; PTD, protein transduction domain; TAT, trans-activator of transcription; GFP, green fluorescent protein; SDS, sodium dodecyl sulfate; PAGE, polyacryl amide gel electrophoresis; HRP, horseradish peroxidase; CLC, Cake-Loving C
Modeling the endosomal escape of cell-penetrating peptides using a transmembrane pH gradient
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; BR, Bacteriorhodopsin; Pyrenebutyrate, 4-(1-pyrenyl)-butyric acid; CQ, chloroquine; POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPG, 1-palmitoyl-2-oleoyl-sn-glycero-3[phospho-rac-(1-glycerol)]; BMP, sn-(3-oleoyl
Insights into cell entry and intracellular trafficking of peptide and protein drugs provided by electron microscopy
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; cryo-EM, cryo-electron microscopy; EM, electron microcopy; ET, electron tomography; HPF, high pressure freezing; immuno-EM, immuno-electron microscopy; IFM, immunofluorescence microscopy; mAb, monoclonal antibody; Tat-SPIONs
Synthesis, characterization and applications of carboxylated and polyethylene-glycolated bifunctionalized InP/ZnS quantum dots in cellular internalization mediated by cell-penetrating peptides
Keywords: CPP، پپتید نفوذی سلولی; BFP, blue fluorescent protein; CPP, cell-penetrating peptide; DMSO, dimethyl sulfoxide; DOTA, 1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetra acetic acid; Dox, doxorubicin; DSPE-PEG(2000), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[carboxy(polyet
Cell-penetrating peptides: 20 years later, where do we stand?
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; MALDI, matrix-assisted laser desorption; TOF, time of flight; MS, mass spectrometry; ON, oligonucleotide; EGFP, enhanced green fluorescent protein; CHO, Chinese hamster ovary; FITC, fluorescein isothiocyanate; CS, chondroiti
Solution NMR studies of cell-penetrating peptides in model membrane systems
Keywords: CPP، پپتید نفوذی سلولی; AMP, antimicrobial peptide; CHAPS, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; CMC, critical micelle concentration; DHPC, L-α-1,2-dihexanoylphosphatidylcholine; CPP, cell-penetrating peptide; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholin
Comparative study on the interaction of cell-penetrating polycationic polymers with lipid membranes
Keywords: CPP، پپتید نفوذی سلولی; ATR-FTIR, attenuated total reflection-Fourier transform infrared; CD, circular dichroism; CPP, cell-penetrating peptide; DPH, diphenyl-1,3,5-hexatriene; DPPG, dipalmitoyl phosphatidylglycerol; DSC, differential scanning calorimetry; FAM, 5-(and 6-)-carbox
Arginine-rich cell-penetrating peptides deliver gene into living human cells
Keywords: CPP، پپتید نفوذی سلولی; BFP, blue fluorescent protein; CMV, cytomegalovirus; CPP, cell-penetrating peptide; Cy3, Cyanine 3; CytD, cytochalasin D; EGFP, enhanced green fluorescent protein; EIPA, 5-(N-ethyl-N-isopropyl)-amiloride; FITC, fluorescein isothiocyanate; GFP, green fluor
Knockdown of a G protein-coupled receptor through efficient peptide-mediated siRNA delivery
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; CQ, chloroquine; EYFP, enhanced yellow-fluorescent protein; GPCR, G protein-coupled receptor; hCT, human calcitonin; HEK-293, human embryonic kidney cells; NPY1R, neuropeptide Y1 receptor; siRNA, small interfering ribonuclei
A gene delivery system for insect cells mediated by arginine-rich cell-penetrating peptides
Keywords: CPP، پپتید نفوذی سلولی; CecB, cecropin B; CPP, cell-penetrating peptide; Cy3, Cyanine 3; EGFP, enhanced green fluorescent protein; GFP, green fluorescent protein; HIV-1, human immunodeficiency virus type 1; HR9, histidine-rich nona-arginine; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5
Receptor-independent cellular uptake of pituitary adenylate cyclase-activating polypeptide
Keywords: CPP، پپتید نفوذی سلولی; ATP, adenosine triphosphate; BOP, benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate; CPP, cell-penetrating peptide; cAMP, cyclic adenosine mono-phosphate; dNTP, deoxynucleotide triphosphate; FITC, Fluorescein isothiocyanate; GPCR
LAH4 enhances CD8+ T cell immunity of protein/peptide-based vaccines
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; CpG, CpG oligonucleotide; DC, dendritic cellCell penetrating peptide; Protein-based vaccine; Peptide-based vaccine; LAH4; Protein delivery; Cross-presentation
Design and characterization of novel cell-penetrating peptides from pituitary adenylate cyclase-activating polypeptide
Keywords: CPP، پپتید نفوذی سلولی; CD, circular dichroism; CHO, Chinese hamster ovary; CPP, cell-penetrating peptide; FITC, fluorescein isothiocyanate; GFP, green-fluorescent protein; hCT, human calcitonin; HEK293, human embryonic kidney 293; MALDI-TOF MS, matrix-assisted laser desorption/
Quantitative assessment of peptide–lipid interactions.: Ubiquitous fluorescence methodologies
Keywords: CPP، پپتید نفوذی سلولی; 6-KC, 6-ketocholestanol; AMP, antimicrobial peptide; BPPZ, 3-(4-{4-[4′-(3-Hydroxybenzo[f]flavonyl)phenyl]piperazino}-1-pyridiniumyl)-1-propanesulfonate; CL, cardiolipin; CPP, cell-penetrating peptide; DHE, dehydroergosterol; di-8-ANEPPS, 4-[2-[6-(dioctyla
Novel immunotherapeutic approaches to skin cancer treatments using protein transduction technology
Keywords: CPP، پپتید نفوذی سلولی; g, antigen; CPP, cell-penetrating peptide; DC, dendritic cell; FCRLA (FCRL), Fc receptor like A; GFP, green fluorescent protein; PTD, protein-transduction domain; HSPG, heparan sulfate proteoglycan; i.d., intradermal; i.t., intratumoral; LACK, Leishmania
Protection by neuroglobin and cell-penetrating peptide-mediated delivery in vivo: A decade of research: Comment on Cai et al.: TAT-mediated delivery of neuroglobin protects against focal cerebral ischemia in mice. Exp Neurol. 2011; 227(1): 224–31
Keywords: CPP، پپتید نفوذی سلولی; bFGF, basic fibroblast growth factor; BBB, blood–brain barrier; BDNF, brain-derived neurotrophic factor; CPP, cell-penetrating peptide; JNK, c-Jun N-terminal kinase; EPO, erythropoietin; KD, gene knock down; JBD, JNK binding domain, a JNK inhibitor; MCAO,
A gene delivery system for human cells mediated by both a cell-penetrating peptide and a piggyBac transposase
Keywords: CPP، پپتید نفوذی سلولی; Cell-penetrating peptide (CPP); Gene delivery; Polyarginine; piggyBac (PB); TransposonBGH, bovine growth hormone; CMV, cytomegalovirus; CNPT, covalent and noncovalent protein transductions; CPP, cell-penetrating peptide; EGFP, enhanced green fluorescent p
Intracellular delivery of quantum dots mediated by a histidine- and arginine-rich HR9 cell-penetrating peptide through the direct membrane translocation mechanism
Keywords: CPP، پپتید نفوذی سلولی; Cell-penetrating peptides (CPPs); Cellular internalization; Protein transduction domains (PTDs); Quantum dots (QDs); SemiconductorAID, arginine-rich intracellular delivery; BFP, blue fluorescent protein; CPP, cell-penetrating peptide; CytD, cytochalasin D
Prodrug-based intracellular delivery of anticancer agents
Keywords: CPP، پپتید نفوذی سلولی; 5-FdU, 5-fluoro-2′-deoxyuridine; Ag, Antigen; ApoE, Apolipolipoprotein E; AraC, 1-β-d-Arabinofuranosylcytosine (cytarabine); BE, Benzyl elimination; CALI, NAc-gamma calicheamycin; CPP, Cell-penetrating peptide; CPT, Camptothecin; DAUN, Daunorubicin; dFdC,
Dual functions of the human antimicrobial peptide LL-37—Target membrane perturbation and host cell cargo delivery
Keywords: CPP، پپتید نفوذی سلولی; AMP, antimicrobial peptide; ATR-FTIR, Attenuated Total Reflection Fourier Transform Infrared; CD, circular dichroism; CPP, cell-penetrating peptide; DPC, Dipalmitoyl Phosphatidyl Choline; DPH, 1,6-diphenyl-1,3,5-hexatriene; HS, Heparan Sulphate; LD, linea
MALDI-TOF mass spectrometry: A powerful tool to study the internalization of cell-penetrating peptides
Keywords: CPP، پپتید نفوذی سلولی; Acm, acetamido; CHCA, α-cyano-4-hydroxycinnamic acid; CHO, Chinese hamster ovary; CPP, cell-penetrating peptide; DTNB, 5,5′-dithio-bis(2-nitrobenzoic acid); DMEM, Dubelcco's modified eagle medium; DTT, dithiotreitol; MALDI-TOF MS, matrix-assisted laser de
Cell biology meets biophysics to unveil the different mechanisms of penetratin internalization in cells
Keywords: CPP، پپتید نفوذی سلولی; Bzp, benzophenone; CHO, Chinese hamster ovary cells; CPP, cell-penetrating peptide; DHPC, dihexanoylphosphatidylcholine; DMPC, dimyristoylphosphatidylcholine; DMPG, dimyristoylphosphatidylglycerol; DPPC, dipalmitoylphosphatidylcholine; DOPC, dioleylphosph
Cationic cell-penetrating peptides induce ceramide formation via acid sphingomyelinase: Implications for uptake
Keywords: CPP، پپتید نفوذی سلولی; ASMase, acid sphingomyelinase; BSA, bovine serum albumin; bSMase, bacterial sphingomyelinase; CPP, cell-penetrating peptide; DMSO, dimethyl sulfoxide; FCS, fetal calf serum; HBS, HEPES-buffered saline; HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic
Membrane-active peptides as anti-infectious agents
Keywords: CPP، پپتید نفوذی سلولی; membrane; cell-penetrating peptide; antimicrobial peptide; antibiotic resistance; infectious diseaseAMP, antimicrobial peptide; CPP, cell-penetrating peptide; DC, dendritic cell; HβD, human β defensin; HNP, human neutrophil peptide (human α-defensin); IM,
Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy
Keywords: CPP، پپتید نفوذی سلولی; 2′-OMe ON, Phosphorothioate 2′-O-methyl RNA; Arg9, Nona-arginine; CPP, Cell-penetrating peptide; CR, Charge ratio; DLS, Dynamic light scattering; HKR, HEPES-buffered Krebs Ringer solution; MR, Molar ratio; ON, Oligonucleotide; Pen, Penetratin; SCO, Splice
PEP and CADY-mediated delivery of fluorescent peptides and proteins into living cells
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; FACS, fluorescence-activated cell sorting; FITC, fluorescein isothiocyanate; NLS, nuclear localization sequence; PTD, protein transduction domain; PNA, peptide nucleic acid; mRFP, monomeric red fluorescent proteinCell-penetr
A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy
Keywords: CPP، پپتید نفوذی سلولی; 2′-OMe ON, phosphorothioate 2′-O-methyl RNA; Arg9, nona-arginine; CPP, cell-penetrating peptide; HKR, HEPES-buffered Krebs Ringer; ON, oligonucleotide; Pen, penetratin; TFA, trifluoroacetc acid; TP10, transportan 10Cell-penetrating peptide; Co-incubation;
The cell-penetrating peptide octa-arginine is a potent inhibitor of proteasome activities
Keywords: CPP، پپتید نفوذی سلولی; Cell-penetrating peptides; Octa-arginine; Proteasome; Inhibitor; Ubiquitin-conjugated proteins; HeLa cellsArg, arginine; Bz-VGR, benzoyl-Val-Gly-Arg; CPP, cell-penetrating peptide; AMC, 7-amino-4-methylcoumarin; Suc-LLVY, succinyl-Leu-Leu-Val-Tyr; Z-LLE,
Elucidating cell-penetrating peptide mechanisms of action for membrane interaction, cellular uptake, and translocation utilizing the hydrophobic counter-anion pyrenebutyrate
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; pyrenebutyrate, 4-(1-pyrenyl)-butyric acid; FACS, fluorescence assisted cell sorting; POPC, palmitoyl-2-oleoyl-phosphatidylcholine; POPG, palmitoyl-2-oleoyl-phosphatidylglycerol; ON, oligonucleotide; LNA, locked nucleic acid
Analysis of in vitro toxicity of five cell-penetrating peptides by metabolic profiling
Keywords: CPP، پپتید نفوذی سلولی; CHO, Chinese hamster ovary cell line; CPP, cell-penetrating peptide; GSH, glutathione; GSSG, glutathione dimer; MAP, model amphipathic peptide; pAntp, third helix (amino acids 43–58) of Drosophila antennapedia homeodomain; PCA, principal component analysi
CPP–protein constructs induce a population of non-acidic vesicles during trafficking through endo-lysosomal pathway
Keywords: CPP، پپتید نفوذی سلولی; Arg9, nona-arginine; AvTxR, avidin labeled with Texas Red; CPP, cell-penetrating peptide; PTD, protein transduction domain; TGN, trans-Golgi network; TP, transportan; TPb, biotinylated transportanCell-penetrating peptides; Endocytosis; Intracellular traff
Efficient induction of apoptosis by doxorubicin coupled to cell-penetrating peptides compared to unconjugated doxorubicin in the human breast cancer cell line MDA-MB 231
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; DHE, dihydro-ethidium; DMSO, dimethyl sulfoxide; Dox, doxorubicine; FACS, fluorescence activated cell sorting; FITC, fluoresceine isothiocyanate; MCa, maurocalcine; MCaAbu, maurocalcine analogue with cysteine residues replac
Penetratin and derivatives acting as antifungal agents
Keywords: CPP، پپتید نفوذی سلولی; Penetratin; Cationic peptides; Cryptococcosis; Candida infections; Molecular dynamics; Conformational analysisAIDS, acquired immunodeficiency syndrome; CPP, cell-penetrating peptide; SA, simulated annealing; MD, molecular dynamics; MIC, minimum inhibitory
Gramicidin A-based peptide vector for intracellular protein delivery
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; PTD, protein transduction domain; NLS, nuclear localization sequence; SV-40, simian virus 40; Tat, CPP, derived from HIV-1; β-Gal, β-galactosidase; oNPG, o-nitrophenil-β-d-galactoside; X-Gal, 5-bromo-4-chloro-3-indolyl-β-d-g
A novel mimovirus vaccine containing survivin epitope with adjuvant IL-15 induces long-lasting cellular immunity and high antitumor efficiency
Keywords: CPP، پپتید نفوذی سلولی; CTL, cytotoxic T lymphocyte; TAA, tumor associated antigen; APC, antigen presenting cell; CPP, cell-penetrating peptide; AICD, activation induced cell death; m-IL-15, mimovirus-IL-15; m-P, mimovirus-Psectag; FCM, flow cytometric assayMimovirus; Survivin;
Insight into the role of HSPG in the cellular uptake of apolipoprotein E-derived peptide micelles and liposomes
Keywords: CPP، پپتید نفوذی سلولی; apoE, apolipoprotein E; BBB, blood brain barrier; bEnd3, mouse brain capillary endothelial cells; BSA, bovine serum albumin; CD, circular dichroism; CPP, cell-penetrating peptide; CLSM, confocal laser scanning microscopy; DPBS, Dulbecco's phosphate buffer
Not miR-ly small RNAs: Big potential for microRNAs in therapy
Keywords: CPP، پپتید نفوذی سلولی; RNA interference; small interfering RNA; microRNA; antagomiRAMD, Age-related macular degeneration; CLL, Chronic lymphocytic leukemia; CPP, Cell-penetrating peptide; dsRNA, Double-strand RNA; HBV, Hepatitis B virus; miRNA, MicroRNA; RISC, RNA-induced silen
Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system
Keywords: CPP، پپتید نفوذی سلولی; Bmpr1a, bone morphogenetic protein receptor type 1 A; CAR, coxsackie and adenovirus receptor; CHEMS, cholesteryl hemisuccinate; Chol, cholesterol; CIDIQ, Confocal image-assisted 3-dimensionally integrative quantification; CPP, cell-penetrating peptide; CW
A Cell-penetrating Helical Peptide as a Potential HIV-1 Inhibitor
Keywords: CPP، پپتید نفوذی سلولی; HIV-1, human immunodeficiency virus type 1; MA, matrix; CA, capsid; NC, nucleocapsid; C-CA, C-terminal domain of capsid; CPP, cell-penetrating peptide; FACS, fluorescence-activated cell sorter; EIAV, equine infectious anemia virus; EM, electron microscope
Differential membrane perturbation caused by the cell penetrating peptide Tp10 depending on attached cargo
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; Tp10, transportan 10; PNA, peptide nucleic acid; LUVs, large unilamellar vesicles; POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPG, 1-palmitoyl-2-oleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]; bt, biotin labele
Bcl-xL protects cerebellar granule neurons against the late phase, but not against the early phase of glutamate-induced cell death
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; FDA, fluorescein diacetate; PI, propidium iodideNecrosis model; Apoptosis; Cell-penetrating peptide; Neurodegeneration; Cerebellar granule neuron; Protein transduction domain
The peptide carrier Pep-1 forms biologically efficient nanoparticle complexes
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; DMEM, Dulbecco’s modified Eagle’s medium; FACS, fluorescence-activated cell sorting; FCS, fetal calf serum; SEM, scanning electron microscopyCell-penetrating peptide; Peptide and protein delivery; Nanoparticle; Morphology; E
Quantitatively determined uptake of cell-penetrating peptides in non-mammalian cells with an evaluation of degradation and antimicrobial effects
Keywords: CPP، پپتید نفوذی سلولی; CPP, cell-penetrating peptide; fl-HPLC, fluorescence-high performance liquid chromatography; MALDI-TOF, matrix assisted laser desorption ionization-time of flight; MAP, model amphipathic peptide; OD, optical density; t-Boc, tert-butyloxycarbonyl; PBS, pho
Developing novel hCT derived cell-penetrating peptides with improved metabolic stability
Keywords: CPP، پپتید نفوذی سلولی; CD, circular dichroism; CF, carboxyfluorescein; CLSM, confocal laser scanning microscopy; CPP, cell-penetrating peptide; DIC, diisopropylcarbodiimide; HATU, O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; hCT, human calcitonin;
Structure–activity relationship study of the cell-penetrating peptide pVEC
Keywords: CPP، پپتید نفوذی سلولی; BMC, Bowes melanoma cells; CPP, cell-penetrating peptide; d-pVEC, ent-pVEC (all-d-enantiomer of pVEC); EIPA, 5-(N-ethyl-N-isopropyl)-amiloride; Fl, 5-(and-6) carboxyfluoresceinyl; HKR, HEPES-buffered Krebs–Ringer solution; LDH, lactate dehydrogenase; MALD
Quantification of the efficiency of cargo delivery by peptidic and pseudo-peptidic Trojan carriers using MALDI-TOF mass spectrometry
Keywords: CPP، پپتید نفوذی سلولی; Acm, acetamidomethyl; Boc, tert-butoxycarbonyl; BSA, bovine serumalbumin; CHCA, α-cyano-4-hydroxycinnamic acid; CHO, Chinese hamster ovary; CPP, cell-penetrating peptide; H-CPP, non-deuterated cell-penetrating peptide; D-CPP, deuterated cell-penetrating p