Keywords: CQ، کلروکین; I/R, ischemia and reperfusion; RIP, receptor-interacting protein; Nec-1, necrostatin-1; ATG, autophagy-related protein; ERK, extracellular signal-regulated kinase; TNF, tumor necrosis factor; ROS, reactive oxygen species; CQ, chloroquine; Rapa, rapamycin;
مقالات ISI CQ، کلروکین (ترجمه نشده)
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Keywords: CQ، کلروکین; Atg, autophagy-related; CPZ, chlorpromazine hydrochloride; CQ, chloroquine; EM, electron microscopy; FPZ, fluphenazine dihydrochloride; HRP, horseradish peroxidase; IND, indatraline hydrochloride; LC3, microtubule-associated protein 1 light chain 3; LOPAC
Keywords: CQ، کلروکین; antimalarials; cutaneous; hydroxychloroquine; lupus erythematosus; smoking; tobaccoCI, confidence interval; CLASI, Cutaneous Lupus Erythematosus Disease Area and Severity Index; CLE, cutaneous lupus erythematosus; CQ, chloroquine; HCQ, hydroxychloroquine;
Keywords: CQ، کلروکین; ART, artemisinin; ACQ, 4-amino-7-chloroquinoline; CQ, chloroquine; MFQ, mefloquine; MLM, HLM, mouse and human liver microsomes, respectivelyMalaria; Thiophene; Furan; Aminoquinoline inhibitors; P. berghei; Chemotherapy; Cytotoxicity; β-Hematin polymerizat
Keywords: CQ، کلروکین; AMPK, AMP-activated protein kinase; Atg, autophagy-related genes; BNIP3, BCL2 and adenovirus E1B 19 kDa-interacting protein 3; BNIP3L, BNIP3 like protein; CQ, chloroquine; Drp1, dynamin-1-like protein; ER, endoplasmic reticulum; Fis1, mitochondrial fissio
Keywords: CQ، کلروکین; BafA1, bafilomycin A1; CNS, central nervous system; CQ, chloroquine; DMSO, dimethyl sulfoxide; 4EBP1, eukaryote initiation factor 4E binding protein 1; FBS, fetal bovine serum; FKBP12, FK506-binding protein 12; FOXO1, forkhead box protein O1; HUVEC, human
Keywords: CQ، کلروکین; Plasmodium falciparum; Allylated chalcones; Chloroquine; Artemisinin; SynergismSAR, Structure–activity relationship; CQ, Chloroquine; ART, Artemisinin; Pf, Plasmodium falciparum
Keywords: CQ، کلروکین; HIF-1α, hypoxia-inducible factor 1-alpha; ROS, reactive oxygen species; OS, osteosarcoma; OC, osteochondroma; LC3, microtubule-associated protein-1 light chain 3; CQ, chloroquine; 3-MA, 3-methyladenineOsteosarcoma; Radioresistance; Hypoxia; Autophagy; HIF
Keywords: CQ، کلروکین; AP, autophagosome; APAP, acetaminophen; APAP-AD, acetaminophen protein adducts; AMAP, 3′-hydroxyacetanilide; ALT, alanine aminotransferase; CQ, chloroquine; CYP2E1, cytochome P450 2E1; GSH, glutathione; HPLC-ED, high pressure liquid chomatography with ele
Keywords: CQ، کلروکین; Purines; Transporter; Malaria; Drug development; Nucleoside/nucleobase transport; Parasite; Plasmodium vivax; Single-nucleotide polymorphism (SNP)ACT, Artemisinin-based Combination Therapies; CQ, chloroquine; EC50, concentration causing 50% of maximal eff
Protective role of autophagy in methionine–choline deficient diet-induced advanced nonalcoholic steatohepatitis in mice
Keywords: CQ، کلروکین; ALT, alanine aminotransferase; CHOP, CCAAT enhancer binding protein homologous protein; CPT-I, carnitine palmitoyl transferase-I; CQ, chloroquine; ER, endoplasmic reticulum; GRP78, glucose-regulated protein 78; LC3, microtubule-associated protein 2 light
Paris Saponin II induced apoptosis via activation of autophagy in human lung cancer cells
Keywords: CQ، کلروکین; Paris Saponin II; Autophagy; Apoptosis; ROSAVOs, acidic vesicular organelles; CQ, chloroquine; GA, gallic acid; NAC, N-acetyl cysteine; p-AKT, Phospho-AKT (phospho-S473); p-ERK1/2, Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204); p-JNK, phospho-SAPK/JNK (Thr
ZT-25, a new vacuolar H+-ATPase inhibitor, induces apoptosis and protective autophagy through ROS generation in HepG2 cells
Keywords: CQ، کلروکین; V-ATPases, vacuolar H+-ATPases; MMP, mitochondrial membrane potential; CQ, chloroquine; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; 3-MA, 3-methyladenine; NAC, N-acetyl-L-cysteine; DMEM, Dulbecco's modified eagle medium; DCFH-DA, 2
Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells
Keywords: CQ، کلروکین; Psoralidin; ROS; NOX4; DNA damage; AutophagyATCC, American type culture collection; CQ, Chloroquine; DCFH2-DA, 5-(6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate; DPI, diphenyleneiodonium chloride; MDC, monodansylcadaverine; MTT, 3-(4,5-cimethylthia
Interference with Akt signaling pathway contributes curcumin-induced adipocyte insulin resistance
Keywords: CQ، کلروکین; Curcumin; Protein kinase B; Autophagy; Ubiquitin proteasome system; AdipocytesAkt, Protein kinase B (PKB/Akt); BFA, Bafilomycin A1; CHX, Cycloheximide; CQ, Chloroquine; Cur, Curcumin; 2-DG, 2-deoxy-D-glucose; GFPu, A green fluorescence protein (GFP) modif
The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair
Keywords: CQ، کلروکین; Breast cancer stem cells; Chloroquine; Mitochondrial damage; Oxidative stressTNBC, triple negative breast cancer; CSCs, cancer stem cells; CQ, chloroquine; FACS, fluorescence-activated cell sorting; MSFE, mammosphere formation efficiency; EM, electron mic
Autophagy activation attenuates angiotensin II-induced cardiac fibrosis
Keywords: CQ، کلروکین; Autophagy; Angiotensin II; Cardiac fibrosis; Rapamycin; ChloroquineAng II, angiotensin II; ECM, extracellular matrix; CFs, cardiac fibroblasts; Rapa, rapamycin; CQ, chloroquine; Col-I, type I collagen; FN, fibronectin; LAMP1, lysosomal associated membrane
Inhibition of autophagy enhances heat-induced apoptosis in human non-small cell lung cancer cells through ER stress pathways
Keywords: CQ، کلروکین; Heat stress; Lung cancer; Autophagy; Apoptosis; ER stressCCK-8, cell counting kit-8; DAPI, 4′,6-diamidino-2-phenylindole; ER stress, endoplasmic reticulum stress; LC3, microtubule-associated protein 1 light chain 3; CQ, chloroquine
SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIγ/AKT-mediated pathway
Keywords: CQ، کلروکین; SKF-96365; Autophagy; Apoptosis; Colorectal cancer; CaMKII△ψm, membrane potential; 3-MA, 3-methyladenine; Ca2+, calcium ion; CaMKIIγ, calmodulin-dependent kinase IIγ; COX-2, cyclooxygenase-2; CQ, chloroquine; CRC, colorectal cancer; cyt c, cytochrome c; E
New quinoline derivatives demonstrate a promising antimalarial activity against Plasmodium falciparum in vitro and Plasmodium berghei in vivo
Keywords: CQ، کلروکین; CQ, chloroquine; ART, artesunate; μg, microgram; μL, microlitre; SI, selectivity index; HeLa, human adenocarcinoma cell line; HepG2, human liver carcinoma cell line; mg/L, milligram/litre; mM, millimolar; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetr
Pre-clinical evaluation of AZD-2014, a novel mTORC1/2 dual inhibitor, against renal cell carcinoma
Keywords: CQ، کلروکین; 3-MA, 3-methyladenine; ATG-5, autophagy protein 5; Cq, chloroquine; RAD001, everolimus; LC3B, light chain 3B; HIF, hypoxia-inducible factor; mTOR, mammalian target of rapamycin; MTT, methylthiazol tetrazolium; PI3K, phosphoinositide-3 kinase; PARP, poly (
Transcription factor IKZF1 is degraded during the apoptosis of multiple myeloma cells induced by kinase inhibition
Keywords: CQ، کلروکین; CDKs, cyclin-dependent kinases; CHX, cycloheximide; CK2, casein kinase II; CQ, chloroquine; CRBN, cereblon; RING, really interesting new gene; CRL4, cullin-4 RING E3 ligase; DDB1, damage-specific DNA-binding protein 1; ROC1, regulator of cullins-1; DRB, 5
Autophagy contributes to the enrichment and survival of colorectal cancer stem cells under oxaliplatin treatment
Keywords: CQ، کلروکین; Colorectal cancer; Autophagy; Cancer stem cells; ChemoresistanceCRC, colorectal cancer; CSCs, cancer stem cells; 5-FU, 5-fluorouracil; OXA, oxaliplatin; H/S, hypoxia/starvation environment; 3-MA, 3-methyladenine; CQ, chloroquine
Dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 synergizes with chloroquine to induce apoptosis in embryonal rhabdomyosarcoma
Keywords: CQ، کلروکین; Apoptosis; NVP-BEZ235; Chloroquine; RhabdomyosarcomaARMS, alveolar RMS; ATTC, American Type Culture Collection; CI, combination index; CQ, chloroquine; ERMS, embryonal rhabdomyosarcoma; FCS, fetal calf serum; GSK3, glycogen synthase kinase 3; mTOR, mammal
Thermoluminescence as a complementary technique for the toxicological evaluation of chemicals in photosynthetic organisms
Keywords: CQ، کلروکین; B-band, TL band due to S2/3QB− recombination; BrB, bromobenzene; C-band, TL band due to D+QA− recombination; CQ, chloroquine; D, tyrosine D of photosystem II; DEA, diethanolamine; EC50, concentration of test chemical that modified the biomarker by 50% in
Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: Involvement of the Akt–mTOR signaling pathway
Keywords: CQ، کلروکین; LDH, lactate dehydrogenase; NAC, N-acety-L-cysteine; DCFH-DA, 2′, 7′-dichlorofluorescein diacetate; CQ, chloroquine; FBS, fetal bovine serum; PI, propidium iodide; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end-labeling; ROS, r
Hsp90 inhibitor 17-AAG sensitizes Bcl-2 inhibitor (-)-gossypol by suppressing ERK-mediated protective autophagy and Mcl-1 accumulation in hepatocellular carcinoma cells
Keywords: CQ، کلروکین; HCC, hepatocellular carcinoma; Hsp90, heat shock protein 90; Bcl-2, B-cell lymphoma-2; LC3, microtubule-associated protein 1 light chain 3; CQ, chloroquine; ERK, extracellular regulated kinase(-)-Gossypol; Bcl-2; Hsp90; Autophagy; ERK
Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol
Keywords: CQ، کلروکین; AOH, alternariol; AO, acridine orange; AMPK, AMP-activated protein kinase; ATM, ataxia telangiectasia mutated; SA-β-Gal, senescence-associate-β-galactosidase; BSA, bovine serum albumin; ConA, concanamycin A; CQ, chloroquine; DMEM, Dulbecco’s modified eagl
tert-Butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation
Keywords: CQ، کلروکین; AMPK, adenosine monophosphate-activated protein kinase; ARE, antioxidant response element; Baf, bafilomycin A1; BSA, bovine serum albumin; CaMKK2, Calcium/calmodulin-dependent protein kinase kinase 2; CQ, chloroquine; EBSS, amino acid and serum depletion
Modeling the endosomal escape of cell-penetrating peptides using a transmembrane pH gradient
Keywords: CQ، کلروکین; CPP, cell-penetrating peptide; BR, Bacteriorhodopsin; Pyrenebutyrate, 4-(1-pyrenyl)-butyric acid; CQ, chloroquine; POPC, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPG, 1-palmitoyl-2-oleoyl-sn-glycero-3[phospho-rac-(1-glycerol)]; BMP, sn-(3-oleoyl
Vitamin D-dependent cathelicidin inhibits Mycobacterium marinum infection in human monocytic cells
Keywords: CQ، کلروکین; CAMP, cathelicidin antimicrobial peptide; VDR, vitamin D receptor; 1,25(OH)2D3, 1α,25-dihydroxyvitamin D3; ATG, autophagy-related genes; CQ, chloroquine; 3-MA, 3-methyladenineCathelicidin antimicrobial peptide; Vitamin D3; Autophagy; Mycobacterium marinum
Autophagy in tumour cell death
Keywords: CQ، کلروکین; ROS, reactive oxygen species; CQ, chloroquine; MOMP, mitochondrial outer membrane permiabilisation; ECM, extracellular matrix; CTL, cytotoxic T-lymphocyte; DAMP, danger-associated molecular pattern; RCC, renal cell carcinoma; PDAC, pancreatic ductal adeno
Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives
Keywords: CQ، کلروکین; Diamidines; Prodrugs; Benzyl phenyl ether derivatives; Antiprotozoal; Antitrypanosomal; Antiplasmodial; AntileishmanialATMS, artemisinin; BPE, benzyl phenyl ether; CQ, chloroquine; FMD, furamidine; HAT, human African trypanosomiasis; IC50, 50% inhibition
Targeting Toll-like receptors by chloroquine protects mice from experimental cerebral malaria
Keywords: CQ، کلروکین; CM, cerebral malaria; CQ, chloroquine; DCs, dendritic cells; ELISA, enzyme linked immunosorbent assay; FCS, fetal calf serum; mDCs, myeloid dendritic cells; MHC, major histocompatibility complex; ODNs, oligodeoxynucleotides; PbA, Plasmodium berghei ANKA;
Autoantibodies in primary Sjögren's syndrome patients induce internalization of muscarinic type 3 receptors
Keywords: CQ، کلروکین; Ca2+]i, cytoplasmic free Ca2+ concentration; CCh, carbachol; CDE, clathrin-dependent endocytosis; CICT, CCh-induced [Ca2+]i transient; CQ, chloroquine; GPCR, G-protein-coupled receptor; hSMG, human submandibular gland; M3R, muscarinic type 3 receptor; pSS
Knockdown of a G protein-coupled receptor through efficient peptide-mediated siRNA delivery
Keywords: CQ، کلروکین; CPP, cell-penetrating peptide; CQ, chloroquine; EYFP, enhanced yellow-fluorescent protein; GPCR, G protein-coupled receptor; hCT, human calcitonin; HEK-293, human embryonic kidney cells; NPY1R, neuropeptide Y1 receptor; siRNA, small interfering ribonuclei
Dihydroartemisinin inhibits the human erythroid cell differentiation by altering the cell cycle
Keywords: CQ، کلروکین; DHA, dihydroartemisinin; ATS, artesunate; ARM, artemisinin; AMS, artemisone; C10-ARM, 10-deoxoartemisinin; Deoxy-ARM, deoxyartemisinin; CQ, chloroquine; RT- PCR, reversed transcribed polymerase chain reaction; DMSO, dimethyl sulfoxide; Hm, haemin; PpIX, p
Targeting autophagy for the treatment of liver diseases
Keywords: CQ، کلروکین; APAP, acetaminophen; ALD, alcoholic liver disease; ALT, alanine aminotransferase; AT, alpha-1-antitrypsin; BAF, Bafilomycin A1; CBZ, carbamazepine; CQ, chloroquine; CMA, chaperone-mediated autophagy; 4EBP1, translational initiation factor 4E binding prote
Cytotoxicity of a mitochondriotropic quercetin derivative: Mechanisms
Keywords: CQ، کلروکین; 3-MA, 3-MethylAdenine; BAPTA-AM, 1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester); BTPI, ButylTriphenylPhosphonium Iodide; CQ, Chloroquine; CsA, Cyclosporin A; CsH, Cyclosporin H; Δμ̃H, proton electrochemical gradient
Novel hybrid molecules based on 15-membered azalide as potential antimalarial agents
Keywords: CQ، کلروکین; Malaria; Antimalarial; Azalide; Quinoline; Hybrid molecules; Synthesis; Plasmodium falciparumAZ, azithromycin; CQ, chloroquine; P. falciparum, Plasmodium falciparum
Resveratrol enhances the therapeutic effect of temozolomide against malignant glioma in vitro and in vivo by inhibiting autophagy
Keywords: CQ، کلروکین; 3-MA, 3-methyladenine; AC, ammonium chloride; BAF, bafilomycin A1; CQ, chloroquine; DCFH-DA, 2,7-dihydrodichlorofluorescein diacetate; DHR123, dihydrorhodamine 123; ERK, extracellular signal-regulated kinase; GBM, glioblastoma multiforme; HEt, dihydroethi
Inhibition of autophagy stimulate molecular iodine-induced apoptosis in hormone independent breast tumors
Keywords: CQ، کلروکین; CQ, chloroquine; I2, molecular iodine; MMTV, mouse mammary tumor virus; ER, estrogen receptorMolecular iodine; Chloroquine; Autophagy
High prevalence of sulfadoxine/pyrimethamine resistance alleles in Plasmodium falciparum parasites from Bangladesh
Keywords: CQ، کلروکین; CQ, chloroquine; SP, sulfadoxine/pyrimethamine; PCR, polymerase chain reactionPlasmodium falciparum; Sulfadoxine/pyrimethamine; dhfr; dhps; Bangladesh; Microsatellite
Selective binding of tumor suppressor p53 protein to topologically constrained DNA: Modulation by intercalative drugs
Keywords: CQ، کلروکین; AA, 2-amino acridine; cccDNA, covalently closed circular DNA; CQ, chloroquine; DX, doxorubicin; Etd, ethidium bromide; p53CON, p53 consensus sequence; linDNA, linear DNA; pro, proflavine; σ, superhelix density; σ0, superhelix density in absence of interca
Early transcriptional response to chloroquine of the Plasmodium falciparum antioxidant defence in sensitive and resistant clones
Keywords: CQ، کلروکین; CQ, chloroquine; IC50, half-maximum inhibitory concentration; ROS, reactive oxygen species; FP IX, ferri/ferroprotoporphyrin IX; IDC, intraerythrocytic developmental cycle; GSH, reduced glutathione; GSSG, glutathione disulphide; AO, acridine orange; EtBr,
Induction of cell death on Plasmodium falciparum asexual blood stages by Solanum nudum steroids
Keywords: CQ، کلروکین; SNs, S. nudum steroids; ΔΨm, mitochondrial membrane potential; CQ, chloroquine; TUNEL, Terminal deoxynucleotidyl transferase-mediated dUTP-fluorescein nick-end labelingSolanum nudum; Plasmodium falciparum; Cell death; Antimalarial drugs
Autophagy and tumorigenesis
Keywords: CQ، کلروکین; ARHI, aplasia Ras homolog member I; ATG, autophagy regulator; BafA, bafilomycin A1; Bif-1, Bax-binding protein-1; C-Vps, class C Vps complex; CML, chronic myelogenous leukemia; CQ, chloroquine; DRAM, damage-regulated autophagy modulator; ER, endoplasmic r
HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia
Keywords: CQ، کلروکین; 4-HPR, N-(4-hydroxyphenyl)retinamide; LC3, microtubule-associated protein light-chain 3; 3-MA, 3-methyladenine; CQ, chloroquine; NAC, N-acetylcysteine; AVO, acidic vesicular organelle; HIF, hypoxia-inducible factors; SRB, sulforhodamine B; PI, propidium i
Persistent cognitive and motor deficits after successful antimalarial treatment in murine cerebral malaria
Keywords: CQ، کلروکین; Plasmodium berghei ANKA; Object recognition; Spatial memory; Motor coordination; Brain pathology; Chloroquine treatmentPbA, Plasmodium berghei ANKA; CQ, chloroquine; CM, Cerebral malaria; RBC, red blood cell; cm, centimeter; dpi, days post-infection
Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice
Keywords: CQ، کلروکین; GFP-LC3; Bodipy Staining; Autophagy Flux; Long-Lived Protein Degradation3-MA, 3-methyladenine; 4-MP, 4-methyl pyrazole; ADH, alcohol dehydrogenase; ALT, alanine aminotransferase; CYP2E1, cytochrome P450 2E1; CQ, chloroquine; EM, electron microscopy; LD, l