Keywords: Asthma; Chronic rhinosinusitis; Fibrin; Nasal polyps; Nattokinase; CRS; Chronic rhinosinusitis; CRSwNP; CRS with nasal polyps; CRSsNP; CRS without nasal polyps; NK; Nattokinase; t-PA; tissue plasminogen activator; PAI-1; plasminogen activator inhibitor-1;