X-ray structure of the ternary MTX·NADPH complex of the anthrax dihydrofolate reductase: A pharmacophore for dual-site inhibitor design
Keywords: DHFR; dihydrofolate reductase; ba; Bacillus anthracis; ec; Escherichia coli; hs; Homo sapiens; MTX; methotrexate; p-ABA; para-aminobenzoic acid; NADPH; nicotinamide adenine dinucleotide phosphate (reduced form); DHF; dihydrofolate; IC50; inhibitor concent