Keywords: Adventitious root; Cryptotanshinone; Tanshinone IIA; Elicitors; Biomass
مقالات ISI (ترجمه نشده)
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Keywords: 7,8-DHF; 7,8-dihydroxyflavone; Aβ; amyloid beta; AchE; acetylcholine-esterase; ABCA1; ATP-binding cassette transporter 1; APP; amyloid precursor protein; Akt; protein kinase B; ApoE; apolipoprotein E; AAV/Aβ; adeno-associated viral vector carrying Aβ c
Keywords: BBB; blood-brain barrier; CAD; Charged Aerosol Detector; CM; chitosan-microsphere; CP; compritol; CTS; cryptotanshinone; DGLC; Double gradient liquid chromatograph; DH-Ppt; dehydrogynated protopanaxatriol; DSS; danshensu; F; bioavailability; FA; ferulic
Keywords: Overall uncertainty; Near infrared; Design of experiment; Uncertainty profile; Cryptotanshinone; Tanshinone extract powder
Keywords: Salvia miltiorrhiza Bunge (Lamiaceae); Cryptotanshinone; Pharmacogenetics; DDIT3; Unfolded protein response (UPR); Eukaryotic initiation factor (eIF)ALL, acute lymphoblastic leukemia; ATF4, activating transcription factor-4; ATF6, activating transcription
Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors
Keywords: TCM; traditional Chinese medicine; DS; Radix Salviae Miltiorrhiaeis; EGFR; epidermal growth factor receptor; FGFR4; fibroblast growth factor receptors 4; CMC; cell membrane chromatography; HPLC-ESI-IT-TOF-MSn; high performance liquid chromatography-electr
Neuroprotective effects of cryptotanshinone and 1,2-dihydrotanshinone I against MPTP induced mouse model of Parkinson's disease
Keywords: 1,2-dihydrotanshinone I (PubChem CID: 105119); cryptotanshinone (PubChem CID: 496348); MPTP (PubChem CID: 1388); Malondialdehyde (PubChem CID: 10964); Parkinson's disease; 1,2-dihydrotanshinone I; Cryptotanshinone; Neuroprotective effect; Antioxidant;
Development of cryptotanshinone-loaded pellets for angina chronotherapy: In vitro/in vivo prediction and evaluation
Keywords: Chronotherapy; Deconvolution; Angina pectoris; Cryptotanshinone; In vitro/in vivo performance; Control release;
Down regulation of pro-inflammatory pathways by tanshinone IIA and cryptotanshinone in a non-genetic mouse model of Alzheimer's disease
Keywords: Aβ1-42 (PubChem CID: 57339251); Cryptotanshinone (PubChem CID: 160254); Tanshinone IIA (PubChem CID: 164676); AD; Alzheimer's disease; APP; amyloid precursor protein; CNS; central nervous system; COX; cyclooxygenase; CRY; cryptotanshinone; CTRL; cont
Diverse responses of tanshinone biosynthesis to biotic and abiotic elicitors in hairy root cultures of Salvia miltiorrhiza and Salvia castanea Diels f. tomentosa
Keywords: AACT; acetyl-CoA C-acetyltransferase; CPS; copalyl diphosphate synthase; CT; cryptotanshinone; CYPs; cytochromes P450; DMAPP; dimethylallyl diphosphate; DT-I; dihydrotanshinone I; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulo
Diverse specialized metabolism and their responses to lactalbumin hydrolysate in hairy root cultures of Salvia miltiorrhiza Bunge and Salvia castanea Diels f. tomentosa Stib
Keywords: CA; caffeic acid; CT; cryptotanshinone; CYP76AH1; cytochrome P450 dependent monooxygenase; CYPs; cytochromes P450; DT-I; dihydrotanshinone I; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulose 5-phosphate synthase; DW; dry weigh
Simultaneous determination of phenolic acids and diterpenoids and their comparative pharmacokinetic study in normal and acute blood stasis rats by UFLC-MS/MS after oral administration of Guan-Xin-Shu-Tong capsules
Keywords: ABS; acute blood stasis; CGA; chlorogenic acid; CHD; coronary heart disease; CTS; cryptotanshinone; DTSI; dihydrotanshinone I; DSS; danshensu; GXSTC; Guan-Xin-Shu-Tong capsules; GA; gallic acid; IS; internal standard; MRM; multiple reaction monitoring; PC
Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2
Keywords: Cytochrome P450; Inhibitory effects; Danshen; CYP2C8; CYP2J2; Herb-drug interactions; AA; arachidonic acid; CA; caffeic acid; Cry; cryptotanshinone; CYPs; Cytochrome P450 enzymes; DSS; danshensu; DI; dihydrotanshinone I; EETs; epoxyeicosatrienoic acids; F
Cryptotanshinone inhibits VEGF-induced angiogenesis by targeting the VEGFR2 signaling pathway
Keywords: CPT; cryptotanshinone; HUVECs; human umbilical vein endothelial cells; VEGF; vascular endothelial growth factor; ERK1/2; extracellular signal-regulated kinase 1/2; FAK; focal adhesion kinase; mTOR; mammalian target of rapamycin; ECM; endothelial cell medi
Cryptotanshinone protects against IL-1β-induced inflammation in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice
Keywords: Cryptotanshinone; Osteoarthritis; Chondrocytes; NF-κB; IL-1β; Inflammation;
Cryptotanshinone induces ROS-dependent autophagy in multidrug-resistant colon cancer cells
Keywords: Cryptotanshinone; Autophagy; Reactive oxygen species; Multidrug resistance; Colon cancer;
Therapeutic effect of Cryptotanshinone on experimental rheumatoid arthritis through downregulating p300 mediated-STAT3 acetylation
Keywords: RA; rheumatoid arthritis; CTS; Cryptotanshinone; DMARDs; disease-modifying anti-rheumatic drugs; FLS; fibroblast-like synoviocytes; CIA; type-II collagen-induced arthritis; STAT; Signal transducer and activator of transcription; IGU; iguratimod; Treg; reg
Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones
Keywords: Cryptotanshinone; Tanshinone IIA; Total tanshinones; Solid dispersion; Dissolution rate;
Cryptotanshinone promotes commitment to the brown adipocyte lineage and mitochondrial biogenesis in C3H10T1/2 mesenchymal stem cells via AMPK and p38-MAPK signaling
Keywords: C3H10T1/2; Cryptotanshinone; Browning; Ucp1; AMPKα; p38-MAPK;
Cryptotanshinone, a compound of Salvia miltiorrhiza inhibits pre-adipocytes differentiation by regulation of adipogenesis-related genes expression via STAT3 signaling
Keywords: Cryptotanshinone; Adipogenesis; C/EBPβ; PPARγ; STAT3; CT; cryptotanshinone; RA; retinoic acid; Tro; troglitazone; C/EBP; CCAAT/enhancer-binding protein; PPARγ; peroxisome proliferation-activity receptor γ; GAPDH; glycerol-3-phosphate dehydrogenase; IB
In vitro inhibitory effects of ethanol extract of Danshen (Salvia miltiorrhiza) and its components on the catalytic activity of soluble epoxide hydrolase
Keywords: Danshen (Salvia miltiorrhiza); Soluble epoxide hydrolase (sEH); Inhibitor; Tanshinone IIA; Cryptotanshinone; Salvianolic acid C
Sensitivity of apoptosis-resistant colon cancer cells to tanshinones is mediated by autophagic cell death and p53-independent cytotoxicity
Keywords: Cryptotanshinone; Dihydrotanshinone; Apoptosis resistance; Autophagic cell death; p53-independent cytotoxicity; Colon cancer;
Therapeutic effect of Cryptotanshinone on collagen-induced arthritis in rats via inhibiting nuclear factor kappa B signaling pathway
Keywords: BMM; bone marrow macrophage; CIA; collagen-induced arthritis; CTS; Cryptotanshinone; FLS; fibroblast-like synoviocytes; Lef; leflunomide; M-CSF; macrophage colony-stimulating factor; MMP; matrix metalloproteinase; PAR; parthenolide; RA; rheumatoid arthr
Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza
Keywords: Cryptotanshinone; Dihydrotanshinone; P-glycoprotein; Multidrug resistance; Salvia miltiorrhiza;
Cryptotanshinone reverses ovarian insulin resistance in mice through activation of insulin signaling and the regulation of glucose transporters and hormone synthesizing enzymes
Keywords: PCOS; ovary; insulin resistance; Chinese medicine; cryptotanshinone;
Proapoptotic and TRAIL-sensitizing constituents isolated from Salvia militiorrhiza (Danshen)
Keywords: Tanshinone IIA; Cryptotanshinone; Tanshinone I; Tumor necrosis factor-related apoptosis-inducing ligand; Ovarian cancer; DanshenPARP, poly(ADP-ribose) polymerase; TRAIL, tumor necrosis factor-related apoptosis-inducing ligand
Coexisted components of Salvia miltiorrhiza enhance intestinal absorption of cryptotanshinone via inhibition of the intestinal P-gp
Keywords: Cryptotanshinone; Salvia miltiorrhiza; Absorption; P-glycoprotein inhibitor; Interaction; HPLC; Everted rat gut sacs;
Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation
Keywords: Cryptotanshinone; Tanshinone IIA; NK cells; Differentiation; Id2;
Cryptotanshinone suppresses androgen receptor-mediated growth in androgen dependent and castration resistant prostate cancer cells
Keywords: Androgen receptor; Anti-androgen; Cryptotanshinone; Danshen; Prostate cancer
Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line
Keywords: CYP; cytochrome P450; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; DRE; dioxin response element; EROD; 7-ethoxyresorufin O-deethylation; B[a]P; benzo[a]pyrene; BNF; β-naphthoflavone; TIIA; tanshinone IIA; CTS; cry
Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and kinetic analysis
Keywords: Cryptotanshinone; Dihydrotanshinone; Cholinesterase; Autodock; Alzheimer's disease;
Cryptotanshinione upregulates α-secretase by activation PI3K pathway in cortical neurons
Keywords: cryptotanshinone; α-secretase; Aβ; ADAM10
Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro
Keywords: Cryptotanshinone; Alzheimer's disease; Amyloid precursor protein (APP); Aβ; α-Secretase;
Cryptotanshinone, a lipophilic compound of Salvia miltiorrriza root, inhibits TNF-α-induced expression of adhesion molecules in HUVEC and attenuates rat myocardial ischemia/reperfusion injury in vivo
Keywords: Cryptotanshinone; Myocardial ischemia and reperfusion injury; Microcirculation disturbance; NF-kB activation; Adhesion molecules; Inflammation;
Dual effects of lipophilic extract of Salvia miltiorrhiza (Danshen) on catecholamine secretion in cultured bovine adrenal medullary cells
Keywords: Adrenal medulla; Catecholamine secretion; Salvia miltiorrhiza; Cryptotanshinone
Mechanisms of the dilator action of cryptotanshinone on rat coronary artery
Keywords: Cryptotanshinone; Danshen; Calcium channel; Coronary artery; (Salvia miltiorrhiza)
Cytotoxicity of major tanshinones isolated from Danshen (Salvia miltiorrhiza) on HepG2 cells in relation to glutathione perturbation
Keywords: Danshen; Salvia miltiorrhiza; Glutathione; Cytotoxicity; HepG2 cells; Cryptotanshinone; Tanshinone I; Tanshinone IIA; Dihydrotanshinone; GSH/GSSG ratio
Structural elucidation of in vitro and in vivo metabolites of cryptotanshinone by HPLC–DAD–ESI–MSn
Keywords: Structural elucidation; Cryptotanshinone; Metabolites; LC–DAD–ESI–MSn
Cryptotanshinone inhibits macrophage migration by impeding F-actin polymerization and filopodia extension
Keywords: Cryptotanshinone; Chemotactic migration; C5a; MIP-1α; Filopodia; F-actin
Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat
Keywords: Salvia miltiorrhiza Bge.; Cryptotanshinone; Tanshinone IIA; Pharmacokinetics; Herb-drug interaction
Simultaneous determination of danshensu, ferulic acid, cryptotanshinone and tanshinone IIA in rabbit plasma by HPLC and their pharmacokinetic application in danxiongfang
Keywords: Danshensu; Ferulic acid; Cryptotanshinone; Tanshinone IIA; Quantification; Pharmacokinetics; HPLC
Tanshinone congeners improve memory impairments induced by scopolamine on passive avoidance tasks in mice
Keywords: Tanshinone I; Tanshinone IIA; Cryptotanshinone; 15, 16-dihydrotanshinone I; Passive avoidance task; Acetylcholinesterase
15,16-Dihydrotanshinone I suppresses the activation of BV-2 cell, a murine microglia cell line, by lipopolysaccharide
Keywords: Microglia; Inflammation; Cryptotanshinone; 15,16-Dihydrotanshinone I;
Cryptotanshinone inhibits cyclooxygenase-2 enzyme activity but not its expression
Keywords: Cryptotanshinone; Cyclooxygenase-2; Prostaglandin E2; Reactive oxygen species
Improved quality control method for Danshen products—Consideration of both hydrophilic and lipophilic active components
Keywords: Cryptotanshinone; Tanshinone I; Tanshinone IIA; Danshensu; Protocatechuic aldehyde; Salvianolic acid B; HPLC
Simultaneous quantification of cryptotanshinone and its active metabolite tanshinone IIA in plasma by liquid chromatography/tandem mass spectrometry (LC–MS/MS)
Keywords: Tanshinone IIA; Cryptotanshinone; Simultaneous quantification; LC–MS/MS; Pharmacokinetics
Cryptotanshinone inhibits endothelin-1 expression and stimulates nitric oxide production in human vascular endothelial cells
Keywords: Cryptotanshinone; Salvia miltiorrhiza; Endothelin-1; Nitric oxide; Vascular endothelial cell
Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-α-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-κB and AP-1
Keywords: Cryptotanshinone; Salviae miltiorrahizae (Salvia miltiorrhiza Bunge); Matrix metalloproteinase-9; Human aortic smooth muscle cells; TNF-α; Migration
Simultaneous determination of tanshinone IIA and cryptotanshinone in rat plasma by liquid chromatography-electrospray ionisation-mass spectrometry
Keywords: Tanshinone IIA; Cryptotanshinone; Liquid chromatography-mass spectrometry; Pharmacokinetics;
Determination of cryptotanshinone and its metabolite in rat plasma by liquid chromatography-tandem mass spectrometry
Keywords: Cryptotanshinone; Tanshinone II A; Metabolism; Pharmacokinetic; LC-MS-MS;