A new series of N5 derivatives of the 1,1,5-trimethyl furo[3,4-c]pyridine-3,4-dione (cerpegin) selectively inhibits the post-acid activity of mammalian 20S proteasomes
Keywords: DMF/DMA, dimethylformamide/dimethylacetal; DMSO, dimethyl sulfoxide; 20S, 20S proteasome catalytic core; CT-L, chymotrypsin-like; T-L, trypsin-like; PA, post-acid or caspase-like; AMC, 7-amino-4-methyl-coumarin; β-NA, β-naphthylamide; PDB, Protein Data Ba