The PrPC C1 fragment derived from the ovine A136R154R171PRNP allele is highly abundant in sheep brain and inhibits fibrillisation of full-length PrPC protein in vitro
Keywords: PrPC, cellular prion protein; CNS, central nervous system; CJD, Creutzfeldt–Jakob disease; CWD, chronic wasting disease; BSE, bovine spongiform encephalopathy; PrPSc, disease associated misfolded prion protein; NPU, Neuropathogenesis Unit; AHVLA, Animal H