Mutational ‘hot-spots’ in mammalian, bacterial and protozoal dihydrofolate reductases associated with antifolate resistance: Sequence and structural comparison
Keywords: DHFR, dihydrofolate reductase; MTX, methotrexate; TMP, trimethoprim; CYC, cycloguanil; PYR, pyrimethamine; NADPH, nicotinamide adenine dinucleotide phosphate (reduced form); DHF, 7,8-dihydrofolate; THF, 5,6,7,8-tetrahydrofolate; PMTX, pemetrexed; TMTX, tr