Design and synthesis of selective CDK8/19 dual inhibitors: Discovery of 4,5-dihydrothieno[3â²,4â²:3,4]benzo[1,2-d]isothiazole derivatives
Keywords: CDK8; CDK19; Cyclin-dependent kinases (CDKs); Transcriptional regulation; STAT1; RPMI8226; SW480; DMG; 4,5-Dihydrothieno[3â²,4â²:3,4]benzo[1,2-d]isothiazole;