
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase
Keywords: CYP11B1 inhibitors; CYP11B2; CYP19; CYP17; Coumarins; Imidazolyl-acetophenonesCYP, cytochrome P450; SAR, structure–activity relationship; SSR, structure–selectivity relationship; QSAR, quantitative structure–activity relationship; CYP19, aromatase; CYP17,