Keywords: CYP2E1، Cytochrome P450 2E1; ALD, alcoholic liver disease; ASH, alcoholic steatohepatitis; AST, aspartate aminotransferase; ALT, alanine aminotransferase; BAL, blood alcohol level; CI, confidence interval; CYP2E1, cytochrome p450 2E1; DNA, deoxyribonucleic acid; HBV, hepatitis B viru
مقالات ISI CYP2E1، Cytochrome P450 2E1 (ترجمه نشده)
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Keywords: CYP2E1، Cytochrome P450 2E1; ACN, acrylonitrile; CYP2E1, cytochrome P450 2E1; GFAP, glial fibrillary acidic protein; GM-CSF, granulocyte–macrophage colony-stimulating factor; GSH, glutathione; IFNγ, interferon γ; IL, interleukin; NF-κB, nuclear factor kappa-light-chain-enhancer of ac
4-Phenylbutyric acid regulates CCl4-induced acute hepatic dyslipidemia in a mouse model: A mechanism-based PK/PD study
Keywords: CYP2E1، Cytochrome P450 2E1; ER, Endoplasmic reticulum; 4-PBA, 4-Phenylbutyric acid; LDL, Low-density lipoprotein; HDL, High-density lipoprotein; PDI, Protein disulfide isomerase; CCl4, Carbon tetrachloride; CYP2E1, Cytochrome P450 2E1; ApoB, Apolipoprotein B; TG, Triglyceride; PK, P
Induction of CYP2E1 in non-alcoholic fatty liver diseases
Keywords: CYP2E1، Cytochrome P450 2E1; CYP2E1, cytochrome P450 2E1; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitisCYP2E1; NASH; NAFLD; Simple steatosis
Chemical characteristics for optimizing CYP2E1 inhibition
Keywords: CYP2E1، Cytochrome P450 2E1; Cytochrome P450 2E1; Topliss; Alcoholic liver disease; Nonalcoholic liver diseaseASH, alcoholic steatohepatitis; NASH, nonalcoholic steatohepatitis; CYP2E1, cytochrome P450 2E1; NADP+, nicotinamide adenine dinucleotide phosphate; TCA, tri-chloro-acetic ac
Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice
Keywords: CYP2E1، Cytochrome P450 2E1; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BSA, bovine serum albumin; CCl4, carbon tetrachloride; COX-2, cyclooxygenase-2; CYP2E1, cytochrome P450 2E1; DMSO, dimethyl sulphoxide; DPPH, 2,2-diphenyl-1-picryl-hydrazyl; DTNB, 5,5′-dithio
Quercetin protects mouse liver against CCl4-induced inflammation by the TLR2/4 and MAPK/NF-κB pathway
Keywords: CYP2E1، Cytochrome P450 2E1; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CAT, catalase; COX-2, cyclooxygenase-2; CYP2E1, cytochrome P450 2E1; iNOS, inducible nitric oxide synthase; MAPK, mitogen-activated protein kinase; QE, quercetin; ROS, reactive oxygen species
Saponins isolated from the leaves of Panax notoginseng protect against alcoholic liver injury via inhibiting ethanol-induced oxidative stress and gut-derived endotoxin-mediated inflammation
Keywords: CYP2E1، Cytochrome P450 2E1; ALD, alcoholic liver disease; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BW, body weight; CYP2E1, cytochrome P450 2E1; GSH, glutathione; H2O2, hydrogen peroxide; HO-1, haem oxygenase-1; HPLC, high performance liquid chromatography; HR
Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury
Keywords: CYP2E1، Cytochrome P450 2E1; ALT, alanine aminotransferase; APAP, acetaminophen; CYP2E1, cytochrome P450 2E1; ERK, extracellular signal-regulated kinase; α-KGDH, α-ketoglutarate dehydrogenase; HAE, 4-hydroxyalkenal; JNK, c-Jun N-terminal protein kinase; MDA, malondialdehyde; MPT, mit
Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats
Keywords: CYP2E1، Cytochrome P450 2E1; ALT, alanine aminotransferase; ALP, alkaline phosphatase; ANOVA, analysis of variance; ARE, antioxidant response element; AST, aspartate aminotransferase; CYP2E1, cytochrome P450 2E1; DHLA, dihydrolipoic acid; ECM, extracellular matrix; ELISA, enzyme-link
Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling
Keywords: CYP2E1، Cytochrome P450 2E1; Cytochrome P450 2E1; c-Jun N-terminal kinase; Alcoholic liver disease; Oxidative stress; Mitogen-activated protein kinasesAPAP, acetaminophen; CYP2E1, cytochrome P450 2E1; ERK1/2, extracellular signal-regulated kinase 1/2; JNK, c-Jun N-terminal kinase; MA
Role and importance of polymorphisms with respect to DNA methylation for the expression of CYP2E1 enzyme
Keywords: CYP2E1، Cytochrome P450 2E1; CYP2E1, cytochrome p450 2E1; DNA, deoxyribonucleic acid; VNTR, Variable Number of Tandem Repeats; CYP, cytochrome p450; ROS, Reactive Oxygen Species; RFLP, Restriction Fragment Length Polymorphism; PCR, Polymerase Chain Reaction; HCC, hepato-cellular carc
Bridging the gap between old and new concepts in drug-induced liver injury
Keywords: CYP2E1، Cytochrome P450 2E1; APAP, acetaminophen; 2-APB, 2-aminoethoxydiphenyl borate; Cx32, connexin 32; CYP2E1, cytochrome P450 2E1; DILI, drug-induced liver injury; MPT, membrane permeability transition; NAC, N-acetylcysteine; NAPQI, N-acetyl-p-benzoquinone imine; OXPHOS, oxidativ
Ethanol potentiates hepatitis B virus replication through oxidative stress-dependent and -independent transcriptional activation
Keywords: CYP2E1، Cytochrome P450 2E1; ADH, acetaldehyde; cccDNA, covalently closed circular DNA; CHB, chronic hepatitis B; CYP2E1, cytochrome p450 2E1; DCFDA, dichlorofluoresceindiacetate; FBS, fetal bovine serum; FXR, farnesoid X receptor; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GSH
Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys
Keywords: CYP2E1، Cytochrome P450 2E1; CYP2B6; CYP2E1; Nicotine; Ethanol; Monkey; Induction; BrainCYPs, cytochrome P450 enzymes; CYP2E1, cytochrome P450 2E1; CYP2B, cytochrome P450 2B; AGM, African green monkey
Aldehyde dehydrogenases in cellular responses to oxidative/electrophilicstress
Keywords: CYP2E1، Cytochrome P450 2E1; ABA, abscisic acid; ADH, alcohol dehydrogenase; ALDH, aldehyde dehydrogenase; CP, cyclophosphamide; CYP2E1, cytochrome P450 2E1; DMSP, dimethyl sulfoniopropionate; G6PD, glucose-6-phosphate dehydrogenase; GABA, γ-aminobutyric acid; 4-HNE, 4-hydroxy-2-none
Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment
Keywords: CYP2E1، Cytochrome P450 2E1; LC3, microtubule associated protein-1 light chain 3; ADH, alcohol dehydrogenase; CYP2E1, cytochrome P450 2E1; SDS–PAGE, sodium dodecyl sulfate; 4-MP, 4-methylpyrazole; DAPI, (4′,6-Diamidine-2′-phenylindole dihydrochloride)Alcoholic liver injury; Oxidant s
Human thyroxine binding globulin (TBG) promoter directs efficient and sustaining transgene expression in liver-specific pattern
Keywords: CYP2E1، Cytochrome P450 2E1; CMV, cytomegalovirus; EF1α, elongation factor 1α; TBG, thyroxine binding globulin; CYP2E1, cytochrome P450 2E1; hAAT, human α1-antitrypsin; AATD, α1-antitrypsin deficiency; PGK, phosphoglycerate kinase; apoE, apolipoprotein E; S.D., standard deviation; RL
Molecular pathogenesis of hepatic fibrosis and current therapeutic approaches
Keywords: CYP2E1، Cytochrome P450 2E1; Collagen; Liver injury; Stellate cells; Extracellular matrixALD, alcoholic liver disease; AP1, activator protein 1; α-SMA, α-smooth muscle actin; CCl4, carbon tetrachloride; CYP2E1, cytochrome P450 2E1; ECM, extracellular matrix; EMT, epithelial-to-mesenc
Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells
Keywords: CYP2E1، Cytochrome P450 2E1; Alcohol; Liver tumors; H-ras; β-Catenin; HNF1αCatnb, β-catenin; CYP2E1, cytochrome P450 2E1; Fabp1, liver fatty acid binding protein 1; Glul, glutamine synthetase; Hnf1α, hepatic nuclear factor 1 alpha; PCNA, proliferating cell nuclear antigen
Secretory phospholipase A2-mediated progression of hepatotoxicity initiated by acetaminophen is exacerbated in the absence of hepatic COX-2
Keywords: CYP2E1، Cytochrome P450 2E1; ALT, alanine aminotransferase; ANOVA, analysis of variance; APAP, acetaminophen; COX-2, cyclooxygenase-2; CYP2E1, cytochrome P450 2E1; GADPH, glyceraldehyde phosphate hydrogenase; KO, knock out; PGs, prostaglandins; sPLA2, secretory phospholipase A2; TNF-
Elevated glutathione level does not protect against chronic alcohol mediated apoptosis in recombinant human hepatoma cell line VL-17A over-expressing alcohol metabolizing enzymes – Alcohol dehydrogenase and Cytochrome P450 2E1
Keywords: CYP2E1، Cytochrome P450 2E1; Ac-DEVD-pNA, Ac-DEVD-p-nitroanilide; ADH, alcohol dehydrogenase; ALD, alcoholic liver disease; CYP2E1, Cytochrome P450 2E1; DAB, 3,3′-diaminobenzidine; DTNB, 5′-dithiobis-2-nitrobenzoic acid; DCF-DA, 2′,7′-dichlorofluorescein diacetate; DMEM, Dulbecco’s m
Impaired methylation as a novel mechanism for proteasome suppression in liver cells
Keywords: CYP2E1، Cytochrome P450 2E1; MHC, major histocompatibility complex; CYP2E1, cytochrome P450 2E1; ADH, alcohol dehydrogenase; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; TBARS, Thiobarbituric Acid Reactive Substances; Cht-L, proteasome chymotrypsin-like activity; ROS, reac
Extract of fermented barley attenuates chronic alcohol induced liver damage by increasing antioxidative activities
Keywords: CYP2E1، Cytochrome P450 2E1; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CAT, catalase; CYP2E1, cytochrome P450 2E1; FBE, fermented barley extract; GPx, glutathione peroxidase; HDL-C, high density lipoprotein cholesterol; MEOS, microsomal ethanol oxidation system;
Biochemical mechanism of Wu-Zi-Yan-Zong-Wan, a traditional Chinese herbal formula, against alcohol-induced oxidative damage in CYP2E1 cDNA-transfected HepG2 (E47) cells
Keywords: CYP2E1، Cytochrome P450 2E1; CYP2E1, cytochrome P450 2E1; DCF-DA, 2′,7′-dichlorofluorescein diacetate; GSH, glutathione in reduced form; LDH, lactate dehydrogenase; MDA, malondialdehyde; PBS, phosphate-buffered saline; ROS, reactive oxygen species; WZ, Wu-Zi-Yan-Zong-WanChinese herba
Peripheral blood effects in benzene-exposed workers
Keywords: CYP2E1، Cytochrome P450 2E1; AIC, Akaike's Information Criterion; BZ, benzene; BMI, body mass index; CI, confidence interval; CYP2E1, Cytochrome P450 2e1; GSTT1, glutathione-S-transferase; MCV, mean corpuscular volume; MPO, myeloperoxidase; MPV, mean platelet volume; NQO1, NAD(P)H qu
Increased mitochondrial stress and modulation of mitochondrial respiratory enzyme activities in acetaminophen-induced toxicity in mouse macrophage cells
Keywords: CYP2E1، Cytochrome P450 2E1; APAP, acetaminophen (N-acetyl-p-aminophenol); COX-2, cyclooxygenase-2; CYP2E1, cytochrome P450 2E1; DMNA, dimethylnitrosamine; GSH, glutathione; Hsp-70, heat shock protein-70; LPS, lipopolysaccharide; NAPQI, n-acetyl-p-benzoquinone imine; NO, nitric oxide
Fatty liver and lipotoxicity
Keywords: CYP2E1، Cytochrome P450 2E1; CAR (NR1I3), constitutive androstane receptor; CYP2E1, cytochrome P450 2E1; ER, endoplasmic reticulum; NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; IR, insulin resistance; FA, fatty acids; PPAR, peroxisome proliferator-ac
Autophagy Reduces Acute Ethanol-Induced Hepatotoxicity and Steatosis in Mice
Keywords: CYP2E1، Cytochrome P450 2E1; GFP-LC3; Bodipy Staining; Autophagy Flux; Long-Lived Protein Degradation3-MA, 3-methyladenine; 4-MP, 4-methyl pyrazole; ADH, alcohol dehydrogenase; ALT, alanine aminotransferase; CYP2E1, cytochrome P450 2E1; CQ, chloroquine; EM, electron microscopy; LD, l
A review of the epidemiologic evidence concerning the reproductive health effects of caffeine consumption: A 2000–2009 update
Keywords: CYP2E1، Cytochrome P450 2E1; ART, assisted reproductive technology; BMI, body mass index; CgA, chromogranin A; CYP1A2, cytochrome P450 1A2; CYP1B1, cytochrome P450 1B1; CYP2E1, cytochrome P450 2E1; GIFT, gamete intra-fallopian transfer; GST, glutathione S-transferase; HR, hazard rati
A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells
Keywords: CYP2E1، Cytochrome P450 2E1; ARE, anti-oxidant response element; CYP2E1, cytochrome P450 2E1; EMSA, electrophoretic mobility shift assay; GFP, green fluorescent protein; Gpx, glutathione peroxidase; H2DCF-DA, 2′,7′-dicholorofluorescin diacetate; MnTBAP, Mn (III) tetrakis (4-benzoic a
Vitamin E supplementation does not prevent ethanol-reduced hepatic retinoic acid levels in rats
Keywords: CYP2E1، Cytochrome P450 2E1; Alc, alcohol (ethanol); CYP2E1, cytochrome P450 2E1; HPLC, high-performance liquid chromatography; PCNA, proliferating cellular nuclear antigen; RA, retinoic acid; VE, vitamin EAlcohol intake; Cell proliferation; CYP2E1; Rat; Retinoic acid; Vitamin E
IP-10 protects while MIP-2 promotes experimental anesthetic hapten - induced hepatitis
Keywords: CYP2E1، Cytochrome P450 2E1; CYP2E1; Trifluoroacetyl chloride; TFA; DILI; MIP-2; IP-10; KC chemokinesAIH, autoimmune hepatitis; CYP2E1, cytochrome P450 2E1; DILI, drug-induced liver injury; IP-10, interferon gamma inducible protein-10; KC, keratinocyte-derived chemokine; KLH, keyhole
Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice
Keywords: CYP2E1، Cytochrome P450 2E1; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CsA, cyclosporin A; CYP2E1, cytochrome P450 2E1; GSH, glutathione; HNE, 4-hydroxynonenal; iNOS, inducible nitric oxide synthase; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccharide; MAPK, m
Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE−/− mouse: Implications for a “multihit” hypothesis of fatty liver disease
Keywords: CYP2E1، Cytochrome P450 2E1; BN–PAGE, blue native gel electrophoresis; CYP2E1, cytochrome P450 2E1; ETS, environmental tobacco smoke; HIF1α, hypoxia-inducible factor 1α; iNOS, inducible nitric oxide synthase; LDL, low-density lipoprotein; mtDNA, mitochondrial DNA; 3-NT, 3-nitrotyrosi
Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: Role of CYP2E1 and TNF-α and activation of JNK and P38 MAP kinase
Keywords: CYP2E1، Cytochrome P450 2E1; ALD, alcoholic liver disease; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CYP2E1, cytochrome P450 2e1; Dex, control dextrose diet; cFLIP, cellular FLICE-like inhibitory protein; EtOH, ethanol diet; GSH, reduced glutathione; HE, hematox
Hepatic effects of a methionine–choline-deficient diet in hepatocyte RXRα-null mice
Keywords: CYP2E1، Cytochrome P450 2E1; L-FABP, liver fatty acid binding protein; Cyp2e1, cytochrome P450 2e1; Cyp4a14, cytochrome P450 4a14; MCD, methionine and choline deficient; PPARα, peroxisome proliferator-activated receptor alpha; SREBP, sterol regulatory element binding protein; ASH, al
Anionic phospholipid-induced regulation of reactive oxygen species production by human cytochrome P450 2E1
Keywords: CYP2E1، Cytochrome P450 2E1; E. coli, Escherichia coli; CYP2E1, cytochrome P450 2E1; NPR, NADPH-dependent cytochrome P450 reductase; PA, phosphatidic acid; PC, phosphatidylcholine; PI, phosphatidylinositol; PS, phosphatidylserine; CL, cardiolipin; POPC, 1-palmitoyl-2-oleoyl-sn-glycer
Lysophosphatidylserine-induced functional switch of human cytochrome P450 1A2 and 2E1 from monooxygenase to phospholipase D
Keywords: CYP2E1، Cytochrome P450 2E1; E. coli, Escherichia coli; PLD, phospholipase D; CYP1A2, cytochrome P450 1A2; CYP2E1, cytochrome P450 2E1; NPR, NADPH-dependent cytochrome P450 reductase; LysoPS, lysophosphatidylserineCytochrome P450; Lysophosphatidylserine; Phospholipase D
Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injury
Keywords: CYP2E1، Cytochrome P450 2E1; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CYP2E1, cytochrome P450 2E1; CRP, c-reactive protein; GSH, glutathione; GSSG, oxidized glutathione; GPX, glutathione peroxidase; IL-6, interleukin-6; MDA, malondialdehyde; PCR, polymerase cha
Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells
Keywords: CYP2E1، Cytochrome P450 2E1; CYP2E1, cytochrome P450 2E1; CcO, cytochrome c oxidase; DCFDA, 2′,7′-dichlorofluorescein diacetate; DMNA, dimethylnitrosamine; DNPH, dinitrophenol hydrazine; GSH, glutathione; GST, glutathione S-transferase; 4-HNE, 4-hydroxynonenal; LPO, lipid peroxidatio
Proteasome Activation by Hepatitis C Core Protein Is Reversed by Ethanol-Induced Oxidative Stress
Keywords: CYP2E1، Cytochrome P450 2E1; CYP2E1, cytochrome P450 2E1; DAS, diallyl sulfide; ER, endoplasmic reticulum; GSH-EE, glutathione ethyl ester; HCV, hepatitis C virus; HSP, heat shock protein; ROS, reactive oxygen species; t-BOOH, t-butyl hydroperoxide
An in vitro method of alcoholic liver injury using precision-cut liver slices from rats
Keywords: CYP2E1، Cytochrome P450 2E1; ATP, adenosine triphosphate; LDH, lactate dehydrogenase; 4-MP, 4-methylpyrazole; AA, acetaldehyde; ALD, alcohol liver disease; ADH, alcohol dehydrogenase; ALDH, aldehyde dehydrogenase; CYP2E1, cytochrome P450 2E1; PCLS, precision-cut liver slicesPrecision
The tandem of free radicals and methylglyoxal
Keywords: CYP2E1، Cytochrome P450 2E1; AG, aminoguanidine; AGE, advanced glycation end-product; ASK1, apoptosis signal-regulating kinase 1; BSA, bovine serum albumin; ATP, adenosine triphosphate; BSO, butionine sulfoximine; CYP2E1, cytochrome P450 2E1; DCFH-DA, 5-(and 6)-carboxy-2′,7′-dichloro
Oxidative and Nitrosative Stress and Fibrogenic Response
Keywords: CYP2E1، Cytochrome P450 2E1; CYP2E1, Cytochrome P450 2E1; ECM, Extracellular matrix; ERK 1/2, Extracellular signal-regulated kinase 1/2; GSH, Glutathione; HSC, Hepatic stellate cells; H2O2, Hydrogen peroxide; IFNγ, Interferon γ; IL, Interleukin; MMPs, Matrix metalloproteinases; MAP
In vitro protection of reactive oxygen species-induced degradation of lipids, proteins and 2-deoxyribose by tea catechins
Keywords: CYP2E1، Cytochrome P450 2E1; CYP2E1, cytochrome P450 2e1; dnph, dinitrophenylhydrazine; dmna, dimethylnitrosamine; EC, (-) epicatechin; ECG, (-) epicatechin gallate; EGCG, (-) epigallocatechin gallate; PMSF, phenyl methylsulfonylfluoride; GSH, glutathione; GST, glutathione S-transfer
Differential Contributions of C3, C5, and Decay-Accelerating Factor to Ethanol-Induced Fatty Liver in Mice
Keywords: CYP2E1، Cytochrome P450 2E1; ASP, acylation-stimulating protein; C3, third component of the complement system; C5, fifth component of the complement system; CYP2E1, cytochrome P450 2E1; DAF, decay-accelerating factor; ELISA, enzyme-linked immunosorbent assay; IFN, interferon; IL, int
Chemoprevention of esophageal squamous cell carcinoma
Keywords: CYP2E1، Cytochrome P450 2E1; AP-1, activator protein-1; ATB, antitumor-B; BITC, benzyl isothiocyanate; BMP-6, bone morphogenetic protein 6; BRB, freeze-dried black raspberries; COX-2, cyclooxygenase-2; CYP2A3, cytochrome P450 2A3; CYP2E1, cytochrome P450 2E1; EA, ellagic acid; 4-ECPR
Acute ethanol pretreatment increases FAS-mediated liver injury in mice: Role of oxidative stress and CYP2E1-dependent and -independent pathways
Keywords: CYP2E1، Cytochrome P450 2E1; ABT, aminobenzotriazole; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CYP2E1, cytochrome P450 2e1; DNPH, 2,4-dinitrophenylhydrazine; GSH, reduced glutathione; GdCl3, gadolinium chloride; HE, hematoxylin-eosin; 4-HNE, 4-hydroxynonenal; I
Ethanol rapidly causes activation of JNK associated with ER stress under inhibition of ADH
Keywords: CYP2E1، Cytochrome P450 2E1; 4-MP, 4-methyl pyrazole; ADH, alcohol dehydrogenase; CYP2E1, cytochrome P450 2E1; DAS, diallyl sulfide; ER, endoplasmic reticulum; GRP78, 78 kDa glucose-regulated protein; GRP, glucose-regulated protein; JIP1, JNK interacting protein 1; JNK, c-Jun NH2-ter