دانلود مقالات ISI درباره Cyp3A + ترجمه فارسی

Effect of hyperlipidemia on ketoconazole-midazolam drug-drug interaction in rat

Keywords: protein binding; CYP3A; pharmacokinetics; pharmacodynamics; enzyme inhibition; antifungal drugs;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Effect of 2 Weeks' Consumption of Pomegranate Juice on the Pharmacokinetics of a Single Dose of Midazolam: An Open-Label, Randomized, Single-Center, 2-Period Crossover Study in Healthy Japanese Volunteers

Keywords: CYP3A; midazolam; pharmacokinetics; pomegranate juice

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Post-translational modification of pregnane x receptor

Keywords: PXR; pregnane x receptor; NR; nuclear receptor; PCN; pregnenalone 16α-carbonitrile; Rif; rifampicin; G6Pase; glucose-6-phosphatase; PEPCK; phosphoenolpyruvate carboxykinase; CYP3A; cytochrome P450 3A; CREs; cyclic AMP response elements; PKA; cyclic AMP-d

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Effect of omeprazole on the pharmacokinetics and toxicities of irinotecan in cancer patients: A prospective cross-over drug-drug interaction study

Keywords: Irinotecan; Omeprazole; Drug-drug interaction; Pharmacokinetics; Toxicities; Neutropenia; Diarrhoea; CYP3A; UGT1A;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Toxicological approach for elucidation of clobazam-induced hepatomegaly in male rats

Keywords: Clobazam; Apoptosis; Hepatomegaly; Cell proliferation; Liver; Oxidative stress; Drug metabolizing enzyme induction; CYP2B; CYP3A; UGT2B;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Effects of simvastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, after oral and intravenous administration in rats: possible role of P-glycoprotein and CYP3A4 inhibition by simvastatin

Keywords: diltiazem; desacetyldiltiazem; simvastatin; CYP3A; P-gp; pharmacokinetics; bioavailability; rats

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Effects of the CYP Oxidoreductase Ala503Val Polymorphism on CYP3A Activity In Vivo: A Randomized, Open-Label, Crossover Study in Healthy Chinese Men

Keywords: Chinese; CYP3A; midazolam; P450 oxidoreductase; polymorphism

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Quantification of cortisol and 6 beta-hydroxycortisol in human urine by LC-MS/MS, and gender-specific evaluation of the metabolic ratio as biomarker of CYP3A activity

Keywords: Cortisol; CYP3A; Metabolite profiling; Humans; Urine; Phenotyping; Gender

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Clarithromycin, a potent inhibitor of CYP3A, greatly increases exposure to oral S-ketamine

Keywords: S-ketamine; Clarithromycin; CYP3A; Interaction; Cold pain;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

High performance liquid chromatographic assay for the simultaneous determination of midazolam and ketoconazole in plasma

Keywords: Drug–drug interaction; CYP3A; HPLC; Pharmacokinetics

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

A pharmacodynamic–pharmacokinetic (PD–PK) study on the effects of Danshen (Salvia miltiorrhiza) on midazolam, a model CYP3A probe substrate, in the rat

Keywords: Danshen (Salvia miltiorrhiza); CYP3A; Midazolam pharmacodynamics/pharmacokinetics in vivo; Rat

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Does exposure to testosterone significantly alter endogenous metabolism in the marine mussel Mytilus galloprovincialis?

Keywords: Testosterone; Mytilus galloprovincialis; Testosterone acyltransferase; CYP3A; Androstenedione; 5α-Reductase; 17β-Hydroxysteroid dehydrogenase; Esterification;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Modulation of acute steroidogenesis, peroxisome proliferator-activated receptors and CYP3A/PXR in salmon interrenal tissues by tributyltin and the second messenger activator, forskolin

Keywords: Tributyltin; PPARs; Forskolin; cAMP; CYP3A; Fish

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Interactions of pharmaceuticals and other xenobiotics on hepatic pregnane X receptor and cytochrome P450 3A signaling pathway in rainbow trout (Oncorhynchus mykiss)

Keywords: Nuclear receptors; PXR; CYP3A; P-glycoprotein; Pharmaceuticals; Fish

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Peroxisome proliferator-activated receptors, estrogenic responses and biotransformation system in the liver of salmon exposed to tributyltin and second messenger activator

Keywords: Tributyltin; Forskolin; Endocrine disruption; Liver; PPAR; Aromatase; CYP3A; Salmon;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients

Keywords: AAIR; atrium paced, atrium sensed inhibited rate modulation; ACC; American College of Cardiology; ACEI; angiotensin converting enzyme inhibitor; ACT; activated clotting time; ADA; American Diabetes Association; AHA; American Heart Association; AMR; antibo

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2010 سفارش ترجمه

Endogenous cortisol 6β-hydroxylation clearance is not an accurate probe for overall cytochrome P450 3A phenotyping in humans

Keywords: CYP3A; Cortisol; 6β-hydroxycortisol; Midazolam

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Human hepatic CYP2B6 developmental expression: The impact of age and genotype

Keywords: CYP450; Ontogeny; CYP2B6; CYP3A; Hepatic

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Validation of a new HPLC method for determination of midazolam and its metabolites: Application to determine its pharmacokinetics in human and measure hepatic CYP3A activity in rabbits

Keywords: HPLC; CYP3A; Therapeutic drug monitoring; Midazolam; Pharmacokinetics

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Effects of atrazine on cytochrome P450 enzymes of zebrafish (Danio rerio)

Keywords: Atrazine; Zebrafish; Cytochrome P450; NADPH-P450 reductase; CYP3A

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1′-hydroxylation and 4-hydroxylation of midazolam

Keywords: SMI; Shenmai injection; MDZ; midazolam; 1′-OH MDZ; 1′-hydroxymidazolam; 4-OH MDZ; 4-hydroxymidazolam; TG; total ginsenoside; OTS; ophiopogon total saponins; OTF; ophiopogon total flavone; KTZ; ketoconazole; RLM; rat liver microsomes; HLM; human liver

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity

Keywords: Methadone; Nelfinavir; CYP3A; CYP2B6; HIV; Drug interactions

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Cytochrome P450 3A, NADPH cytochrome P450 reductase and cytochrome b5 in the upper airways in horse

Keywords: Cytochrome P450; CYP3A; Extrahepatic metabolism; Cytochrome b5; NADPH P450 reductase; Horse

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Presystemic elimination of budesonide in man when administered locally at different levels in the gut, with and without local inhibition by ketoconazole

Keywords: CYP3A; Intubation; Small intestine; Colon; First-pass metabolism; Budesonide

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Molecular characterization of cytochrome P450 1A and 3A and the effects of perfluorooctanoic acid on their mRNA levels in rare minnow (Gobiocypris rarus) gills

Keywords: Perfluorooctanoic acid (PFOA); Rare minnow; CYP1A; CYP3A; Aryl hydrocarbon receptor (AhR); Pregnane X receptor (PXR);

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Ketoconazole, an antifungal imidazole, increases the sensitivity of rainbow trout to 17α-ethynylestradiol exposure

Keywords: CYP1A; CYP3A; Vitellogenin; Ethynylestradiol; Ketoconazole; Fish

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Effects of mammalian CYP3A inducers on CYP3A-related enzyme activities in grass carp (Ctenopharyngodon idellus): Possible implications for the establishment of a fish CYP3A induction model

Keywords: Aminopyrine N-demethylase; CYP3A; Erythromycin N-demethylase; Grass carp; Induction; In vitro model; Rifampicin; Teleost; 6β-Testosterone hydroxylase

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Species Differences in In Vitro and In Vivo Small Intestinal Metabolism of CYP3A Substrates

Keywords: species differences; CYP3A; small intestine; metabolism; first‐pass;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2008 سفارش ترجمه

A developed determination of midazolam and 1′-hydroxymidazolam in plasma by liquid chromatography–mass spectrometry: Application of human pharmacokinetic study for measurement of CYP3A activity

Keywords: Midazolam; 1′-Hydroxymidazolam; CYP3A; LC–MS

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: Is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism?

Keywords: Cynomolgus monkey; CYP2A; CYP2C76; CYP2E; CYP2J; CYP3A; CYP4A; CYP4F; Drug-metabolizing capability; Tissue expression pattern

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Estrogenic modulation of CYP3A38, CYP3A40, and CYP19 in mature male medaka (Oryzias latipes)

Keywords: CYP19; CYP3A; Endocrine-disruption; Estrogenic modulation; Medaka; Testosterone

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

The human cytochrome P450 sub-family: Transcriptional regulation, inter-individual variation and interaction networks

Keywords: CYP3A; Gene expression; PXR; CAR; Nuclear receptor; Inter-individual variability; Drug–drug interactions

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Hepatic metabolism, phase I and II biotransformation enzymes in Atlantic salmon (Salmo Salar, L) during a 12 week feeding period with graded levels of the synthetic antioxidant, ethoxyquin

Keywords: Synthetic antioxidant; Ethoxyquin; EQ; Salmon; UDPGT; GST; CYP1A; CYP3A; AhRα

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2007 سفارش ترجمه

Identification and hepatic expression profiles of cytochrome P450 1-4 isozymes in common minke whales (Balaenoptera acutorostrata)

Keywords: Common minke whale; CYP2C; CYP2E; CYP3A; CYP4A; CYP4V; mRNA expression;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2007 سفارش ترجمه

Contributions of intestinal P-glycoprotein and CYP3A to oral bioavailability of cyclosporin A in mice treated with or without dexamethasone

Keywords: Cyclosporin A; Bioavailability; P-glycoprotein; Dexamethasone; CYP3A; mdr1a/1b knockout mice

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Evidence for cytochrome P450 3A expression and catalytic activity in rat blood lymphocytes

Keywords: CYP3A; Rat; Lymphocytes; Biomarker; Enzyme; mRNA; Protein

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

The influence of CYP3A gene polymorphisms on cyclosporine dose requirement in renal allograft recipients

Keywords: cyclosporine; CYP3A; gene polymorphism; renal allograft

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Curcumin modulates drug metabolizing enzymes in the female Swiss Webster mouse

Keywords: Curcumin; CYP3A; CYP1A; Glutathione S-transferase

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

The xenoestrogen 4-nonylphenol modulates hepatic gene expression of pregnane X receptor, aryl hydrocarbon receptor, CYP3A and CYP1A1 in juvenile Atlantic salmon (Salmo salar)

Keywords: Xenoestrogen; Nonylphenol; CYP3A; CYP1A1; PXR; AhR; Biotransformation; Salmon

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

The effect of tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs) and newer antidepressant drugs on the activity and level of rat CYP3A

Keywords: Antidepressants; Rat; CYP3A; Direct effect; One-day treatment; Chronic treatment

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes

Keywords: Acetaminophen; Bilobalide; CYP3A; Cytochrome P450; Ginkgo biloba; Ginkgolide A; Ginkgolide B; Ginkgolide C; Ginkgolide J; Isorhamnetin; Kaempferol; Quercetin; Triacetyloleandomycin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin A absorption, and effect of dexamethasone in small intestine of mice

Keywords: Cyclosporin A; Bioavailability; P-glycoprotein; Dexamethasone; CYP3A; In situ loop; mdr1a/1b knockout mice

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Generation of specific antibodies and their use to characterize sex differences in four rat P450 3A enzymes following vehicle and pregnenolone 16α-carbonitrile treatment

Keywords: CYP3A; Cytochrome P450 3A; P450 3A1; P450 3A2; P450 3A9; P450 3A18; Specific antibody; Quantitative Western blot; Baculovirus expression system; Testosterone metabolism; Pregnenolone 16α-carbonitrile

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Induction and inhibition of cytochrome P450-dependent monooxygenases of rats by fungicide bitertanol

Keywords: I.P., intraperitoneally; Mab, monoclonal antibody; 3-MC, 3-methylcholanthrene; P450, cytochrome P450; RT-PCR, reverse transcription-polymerase chain reaction; S-9, postmitochondrialBitertanol; Induction; Inhibition; CYP1A1; CYP2B; CYP3A

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Cigarette smokers differ in their handling of natural (RRR) and synthetic (all rac) α-tocopherol: A biokinetic study in apoE4 male subjects

Keywords: ROS; reactive oxygen species; RNS; reactive nitrogen species; CHD; coronary heart disease; α-TTP; α-tocopherol transfer protein; α-CEHC; α-carboxyethyl-hydroxychroman; CIU; clinical investigation unit; 8-iso-PGF2α; 8-iso-prostaglandin F2α; CYP; cyto

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Pharmacogenetics of irinotecan metabolism and transport: An update

Keywords: CPT-11; SN-38; CYP3A; CES; UGT1A; ABCB1; ABCC1; ABCC2; ABCG2

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

Role of pharmacogenetics in irinotecan therapy

Keywords: Irinotecan; Metabolism; Pharmacogenetics; Polymorphism; CYP3A; UGT1A; ABC-transporters

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2006 سفارش ترجمه

Expression of PXR, CYP3A and MDR1 genes in liver of zebrafish

Keywords: Pregnane X-receptor; Cytochrome P4503A; Multidrug-resistance; Zebrafish; Pregnenolone 16α-carboninitrile; Clotrimazole; Nifedipine; PXR; CYP3A; MDR;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Cyclic AMP-independent activation of CYP3A4 gene expression by forskolin

Keywords: Pregnane-X-receptor; Forskolin; CYP3A;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Simultaneous determination of 6β-hydroxycortisol and cortisol in human urine and plasma by liquid chromatography with ultraviolet absorbance detection for phenotyping the CYP3A activity

Keywords: 6β-Hydroxycortisol; Cortisol; HPLC; CYP3A;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه