دانلود مقالات ISI درباره CYP450، سیتوکروم P450 + ترجمه فارسی

اثرات وضعیت هورمون تیروئید بر مسیرهای متابولیک اسید آراشیدونیک در موش و انسان: روش متابومیسی هدفمند

Effects of thyroid hormone status on metabolic pathways of arachidonic acid in mice and humans: A targeted metabolomic approach

Keywords: CYP450، سیتوکروم P450; COX, cyclooxygenase; CYP450, cytochrome P450; 11d-TXB2, 11-dehydro-TXB2; 15d-PGJ2, 15-deoxy-delta-12,14-prostaglandin J2; DHET, dihydroxyeicosatrienoic acid; EET, epoxyeicosatrienoic acid; HETE, hydroxyeicosatetraenoic acid; HDL, high-density lipoprotein;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

متابولومیکها تشکیل آلدئیدها و امینیم را در متابولیسم ژفیتینیب نشان می دهد

Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism

Keywords: CYP450، سیتوکروم P450; CYP450, cytochrome P450; HLM, human liver microsomes; MLM, mouse liver microsomes; GEF, gefitinib; KCZ, ketoconazole; CPT, cisplatin; KCN, potassium cyanide; ILD, interstitial lung disease; GSH, glutathione; OPLS-DA, orthogonal projection to latent struct

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

اثرات سموم در حال حاضر استفاده شده و مخلوط آنها بر عملکرد هورمون تیروئید و گیرنده های آرویل هیدروکربن در کشت سلولی

Effects of currently used pesticides and their mixtures on the function of thyroid hormone and aryl hydrocarbon receptor in cell culture

Keywords: CYP450، سیتوکروم P450; AhR, Aryl hydrocarbon receptor; CA, Concentration addition; CV, Coefficient of variation; CYP450, Cytochrome P450; DAR, Draft Assessment Report; DMSO, Dimethyl sulfoxide; ETU, Ethylenethiourea (mancozeb metabolite); HAH, Halogenated aromatic hydrocarbon;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

The effect of n-3 LCPUFA supplementation on oxidative stress and inflammation in the placenta and maternal plasma during pregnancy

Keywords: CYP450، سیتوکروم P450; CYP450, cytochrome P450; JZ, junctional zone; LPS, lipopolysaccharide; LZ, labyrinth zone; OS, oxidative stress; ROS, reactive oxygen species; RNS, reactive nitrogen speciesOmega-3 fatty acids; Pregnancy; Placenta; Oxidative stress; Inflammation; Nutritio

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Sub-lethal effects and bioconcentration of the human pharmaceutical clotrimazole in rainbow trout (Oncorhynchus mykiss)

Keywords: CYP450، سیتوکروم P450; Biomarkers; Depuration half time; Hematology; HistopathologyBFCOD, 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase; CAT, Catalase; CF, Condition factor; CLO, clotrimazole; CYP450, cytochrome P450; EROD, ethoxyresorufin O-deethylase; GPx, Glutathione p

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Characterizing novel metabolic pathways of melatonin receptor agonist agomelatine using metabolomic approaches

Keywords: CYP450، سیتوکروم P450; CYP450, cytochrome P450; HLM, human liver microsomes; AGM, agomelatine; KCZ, ketoconazole; NF, α-naphthoflavone; GSH, reduced glutathione; NAc, N-acetyl cysteine; OPLS-DA, orthogonal projection to latent structures-discriminant analysis; UHPLC, ultra-high

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Recent Advances in chemistry and pharmacology of 2-methoxyestradiol: An anticancer investigational drug

Keywords: CYP450، سیتوکروم P450; ROS, reactive oxygen species; CYP450, cytochrome P450; VEGFR, vascular endothelial growth factor; HIF, hypoxia inducible factor; PDT, podophyllotoxin; Cdk, cyclin-dependent kinase; TNF, tumour necrosis factor2-Methoxyestradiol; Anticancer; Structure-activ

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2016 سفارش ترجمه

Does dexamethasone affect hepatic CYP450 system of fish? Semi-static in-vivo experiment on juvenile rainbow trout

Keywords: CYP450، سیتوکروم P450; AhR, aryl hydrocarbon receptor; BFCOD, 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase; BQ, 7-benzyloxyquinoline; BQOD, 7-benzyloxyquinoline O-debenzylase; DEX, dexamethasone; EROD, ethoxyresorufin O-deethylase; CYP450, cytochrome P450; PNPH, p-nitrop

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Leukotriene receptor antagonist as a novel tocolytic in an in vitro model of human uterine contractility

Keywords: CYP450، سیتوکروم P450; 5-LO, 5-lipoxygenase; 12-LO, 12-lipooxygenase; AA, arachidonic acid; CysLTR1, cysteinyl leukotrienes receptor 1; COX, cyclooxygenase; CYP450, cytochrome P450; DAG, diacylglycerol; EETs, epoxy-eicosatrienoic acid regioisomers; IP3, inositol 1,4,5-triphosph

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

In vitro identification of cytochrome P450 isoforms responsible for the metabolism of 1-hydroxyl-2,3,5-trimethoxy-xanthone purified from Halenia elliptica D. Don

Keywords: CYP450، سیتوکروم P450; HM-1, 1-hydroxyl-2,3,5-trimethoxyxanthone; HM-5, 1,5-dihydroxy-2,3-dimethoxyxanthone; CYP450, cytochrome P450; LCMSn-IT-TOF, liquid chromatography-ion trap-time-of-flight mass spectrometry; MSn, multi-stage mass spectrum; 1H NMR, hydrogen-1 NMR; 13C NMR,

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Raloxifene preserves phenytoin and sodium valproate induced bone loss by modulating serum estradiol and TGF-β3 content in bone of female mice

Keywords: CYP450، سیتوکروم P450; AED, antiepileptic drug; ALP, alkaline phosphatase; BMD, bone mineral density; BTMs, bone turnover markers; CVD, calcium vitamin D; CYP450, cytochrome P450; DEXA, dual energy X- ray absorptiometry; HxP, hydroxyproline; PHT, phenytoin; RLX, raloxifene; SER

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Metabolites analysis, metabolic enzyme activities and bioaccumulation in the clam Ruditapes philippinarum exposed to benzo[a]pyrene

Keywords: CYP450، سیتوکروم P450; 6-CF, 6-carboxyfluorescein; AHH, aryl hydrocarbon hydroxylase; B[a]P, benzo[a]pyrene; BHT, butylhydroxytoluen; BkF, benzo(k)fluoranthene; BPDE, B[a]P diolepoxides; CDNB, 1-Chloro-2,4-dinitrobenzene; CYP450, cytochrome P450; DD, dihydrodiol dehydrogenase; d

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Rapid and simultaneous quantitation of prostanoids by UPLC–MS/MS in rat brain

Keywords: CYP450، سیتوکروم P450; AA, arachidonic acid; UPLC–MS/MS, ultra performance liquid chromatography tandem mass spectrometry; COX, cyclooxygenase; PG, prostaglandins; CYP450, cytochrome P450; SPE, solid phase extraction; QC, quality control; CV, coefficient of variation; HETE, hyd

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Influence of MDR1 C1236T polymorphism on lopinavir plasma concentration and virological response in HIV-1-infected children

Keywords: CYP450، سیتوکروم P450; ABC, ATP-binding cassette; CDC, Centers for Disease Control and Prevention; CYP450, Cytochrome P450; HAART, highly active antiretroviral therapy; HPLC, high-performance liquid chromatography; LPV, lopinavir; LPV/r, HAART with lopinavir boosted with ritona

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

The influence of cylindrospermopsin on oxidative DNA damage and apoptosis induction in HepG2 cells

Keywords: CYP450، سیتوکروم P450; CYN, cylindrospermopsin; BER, base excision repair; CYP450, cytochrome P450; DCF, 2′,7′-dichlorofluorescein; DCFH-DA, 2′,7′-dichlorfluorescein-diacetate; DSB, double strand break; Fpg, formamidopyrimidine glycosylase; HPBLs, human peripheral blood lymphoc

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Structural organization and classification of cytochrome P450 genes in flax (Linum usitatissimum L.)

Keywords: CYP450، سیتوکروم P450; CYP450, cytochrome P450; BLAST, Basic Local Alignment Search Tool; EST, expressed sequence tag; MEGA, Molecular Evolutionary Genetics Analysis; BLAT, Blast like alignment tool; CDS, coding sequence; UTR, un translated region; UGT, UDP-glycosyltransferases

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Cytochrome P450 2A13 enhances the sensitivity of human bronchial epithelial cells to aflatoxin B1-induced DNA damage

Keywords: CYP450، سیتوکروم P450; CYP450, Cytochrome P450; AFB1, Aflatoxin B1; BEAS-2B cells, immortalized human bronchial epithelial cells; B-2A13 cells, BEAS-2B cells stably expressing CYP2A13; AFB1-FAPY, AFB1-formamidopyrimidine; AFB1-N7-Gua, trans-8,9-dihydro-8-(N7-guanyl)-9-hydroxyaf

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections

Keywords: CYP450، سیتوکروم P450; AA, arachidonic acid; ALR, AIM2-like receptor; CFU, colony forming units; COX, cyclooxygenase; CYP450, cytochrome P450; DDXs/DHXs, DExD/H box proteins; DHA, docosahexaenoic acids; diHETrE, dihydroxy-eicosatrienoic acids; diHOME, dihydroxy-octadecenoic aci

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Phytosynergy in some Hypoxis species and pharmacological properties of a Hypoxis-based phytopharmaceutical formula

Keywords: CYP450، سیتوکروم P450; AChE, acetylcholinesterase; AIDS, acquired immunodeficiency syndrome; APE, African potato extract (Ngwenya quality products); ATCC, American type culture collection; B.s., Bacillus subtilis; COX, cyclooxygenase; CYP450, cytochrome P450; E.c., Escherichia

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Semi-mechanistic physiologically-based pharmacokinetic modeling of clinical glibenclamide pharmacokinetics and drug–drug-interactions

Keywords: CYP450، سیتوکروم P450; DDI, drug–drug interaction; CYP450, cytochrome P450; SU, sulfonylurea; PBPK-model, physiologically-based pharmacokinetic model; Cmax, maximum plasma concentration; AUC, area under the plasma concentration time curve; ADME, absorption, distribution, metabo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Increased EETs participate in peripheral endothelial dysfunction of cirrhosis

Keywords: CYP450، سیتوکروم P450; EET, epoxyeicosatrienoic acid; AA, arachidonic acid; CYP450, cytochrome P450; ET, endothelin; l-NAME, l-NG-Nitroarginine methyl ester; NO, nitric oxide; NOS, nitric oxide synthase; CO, carbon monoxideCirrhosis; Hyperdynamic circulation; Portal hypertensio

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Maternal hair testing for the assessment of fetal exposure to drug of abuse during early pregnancy: Comparison with testing in placental and fetal remains

Keywords: CYP450، سیتوکروم P450; CYP450, cytochrome P450; MAM, 6-monoacetylmorphine; MOR, morphine; COC, cocaine; BEG, benzoylecgonine; MDMA, 3,4-methylenedioxymethamphetamine; MA, methamphetamine; THC, delta-9-tetrahydrocannabinol; THCCOOH, 11-nor-D9-tetrahydrocannabinol-9-carboxylic ac

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Genotoxic and enzymatic effects of fluoranthene in microsomes and freshly isolated hepatocytes from sole (Solea solea)

Keywords: CYP450، سیتوکروم P450; ADL, aldehydic DNA lesions; AHR, aryl hydrocarbon receptor; AHRR, aryl hydrocarbon receptor repressor; BaP, benzo[a]pyrene; CYP1A1, cytochrome P450 1A1; CYP450, cytochrome P450; DMSO, dimethyl sulfoxide; DNA, deoxyribonucleic acid; EROD, ethoxyresorufin-O

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Structure-based phylogeny of polyene macrolide antibiotic glycosyltransferases

Keywords: CYP450، سیتوکروم P450; AGTs, antibiotic glycosyltransferases; AIC, akaike information criterion; BIC, Bayesian information criterion; CYP450, cytochrome P450; FGTs, flavonoid glycosyltransferases; GT, glycosyltransferase; HGT, horizontal gene transfer; MCMCMC, Metropolis-couple

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Endogenous bile acid disposition in rat and human sandwich-cultured hepatocytes

Keywords: CYP450، سیتوکروم P450; BA, bile acids; BSEP, bile salt export pump; BEI, biliary excretion index; CTL, control; CYP450, cytochrome P450; DMSO, dimethyl sulfoxide; DMEM, Dulbecco's modified Eagle medium; EDTA, ethylenediaminetetraacetic acid; GCDCA, glycochenodeoxycholic acid; G

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Treprostinil Improves Hepatic Cytochrome P450 Activity during Rat Liver Transplantation

Keywords: CYP450، سیتوکروم P450; drug metabolism; Ischemia-reperfusion injury; HPLC-mass spectrometry; prostacyclin; cytokinesI/R, ischemia-reperfusion; OLT, orthotopic liver transplantation; PGI2, prostacyclin; CYP450, cytochrome P450; MDZ, midazolam; 1-OH MDZ, 1-hydroxymidazolam; CZN,

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes

Keywords: CYP450، سیتوکروم P450; DEC1, differentially expressed in chondrocytes 1; IL-6, interleukin-6; CYP450, cytochrome P450; PXR, pregnane X receptor; hPXR, human pregnane X receptor; Rif, rifampicin; TNF-α, tumor necrosis factor α; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; PC

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

11,12-EET increases porto-sinusoidal resistance and may play a role in endothelial dysfunction of portal hypertension

Keywords: CYP450، سیتوکروم P450; EET, epoxyeicosatrienoic acid; 20-HETE, 20-hydroxyeicosatetraenoic acid; AA, arachidonic acid; CYP450, cytochrome P450; PE, phenylephrine; ET, endothelin; DBDD, dibromododecenoic acid; CCl4, carbon-tetrachloride; COX, cyclooxygenaseLiver circulation; Arac

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Inhibition of epoxy-eicosanoid degradation improves the tocolytic effects of indomethacin in the uterus from pregnant women

Keywords: CYP450، سیتوکروم P450; AUDA, 12-(3-adamantan-1-yl-ureido)-dodecanoic acid; COX, cyclooxygenase; CYP450, cytochrome P450; DDMS, N-methylsulfonyl-12,12-dibromododec-11-enamide; EET, epoxyeicosatrienoic acid; HETE, hydroxyeicosatetranoic acid; IC25, inhibiting concentration 25%; I

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Metabolism mediated interaction of α-asarone and Acorus calamus with CYP3A4 and CYP2D6

Keywords: CYP450، سیتوکروم P450; AC, Acorus calamus; CYP450, Cytochrome P450; HPLC, high-performance liquid chromatography; RLM, Rat liver microsome; AMMC, (3-[2-(N,N-diethyl-N-methylamino)ethyl]-7-methoxy-4-methylcoumarine); AHMC, (3-[2-(N,N-diethylamino) ethyl]-7-hydroxy-4-methylcoumar

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Cytochrome P450 inhibitory potential of Triphala—A Rasayana from Ayurveda

Keywords: CYP450، سیتوکروم P450; CYP450, cytochrome P450; EO, Emblica officinalis; TB, Terminalia belerica; TC, Terminalia chebula; TL, Triphala formulationAyurveda; Rasayana; Cytochrome P450; Inhibition; Herbal formulation; Triphala; Safety; Herb–drug interaction

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Aromatase, estrone sulfatase, and 17β-hydroxysteroid dehydrogenase: Structure–function studies and inhibitor development

Keywords: CYP450، سیتوکروم P450; AI, aromatase inhibitor; CPR, NADPH-cytochrome P450 reductase; CYP450, cytochrome P450; E2, 17β-estradiol; 17β-HSD, 17β-hydroxysteroid dehydrogenase; 17β-HSD1, 17β-hydroxysteroid dehydrogenase type 1; ER, estrogen receptor; FG, hydroxylformylglycineAromat

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Cytochrome P450 1 enzyme inhibition and anticancer potential of chromene amides from Amyris plumieri

Keywords: CYP450، سیتوکروم P450; CYP450, cytochrome P450; PAH, polycyclic aromatic hydrocarbon; AhR, aryl hydrocarbon receptor; DMBA, 7,12-dimethylbenz(a)anthracene; B[a]P, benzo-a-pyreneAnticancer; CYP450; Chemoprotection; Chemoprevention; Natural products; Jamaica

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Ultraviolet-radiation induced skin inflammation: dissecting the role of bioactive lipids

Keywords: CYP450، سیتوکروم P450; AA, arachidonic acid; ALA, α-linolenic acid; COX, cyclooxygenase; CYP450, cytochrome P450; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; IKK, inhibitor of NFκB (IκB) kinase; LA, linoleic acid; ROS, reactive oxygen species; LOX, lipoxygenase; PUFA

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants

Keywords: CYP450، سیتوکروم P450; CYP450, cytochrome P450; MDMA, 3,4-methylenedioxymethamphetamine; MDA, 3,4-methylenedioxyamphetamine; HHMA, 3,4-dihydroxymetamphetamine; HHA, 3,4-dihydroxyamphetamine; 5-GSH-HHMA, 5-(glutathion-S-yl)-3,4-dihydroxymethamphetamine; 2,5-GSH-HHMA, 2,5-(glutat

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

3,4-Methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition

Keywords: CYP450، سیتوکروم P450; CYP450, cytochrome P450; PXR, pregnane X receptor; MDMA, 3,4-methylenedioxymethamphetamine; DZ, diazepam; DPH, phenytoin; CLZ, clozapine; RSP, risperidone; FLX, fluoxetine; PX, paroxetine; mCPP, chlorophenylpiperazine; AP, amphetamine; R, rifampicin; PCN,

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

The role of free radical generation in increasing cerebrovascular permeability

Keywords: CYP450، سیتوکروم P450; cGMP, cyclic guanosine monophosphate; COX, cyclooxygenase; CYP450, cytochrome P450; EC50, half-maximal effective concentration; eNOS, endothelial nitric oxide synthase; HMGB1, high-mobility group box 1; HUVEC, human umbilical vein endothelial cell; IL-1β,

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

A review of the genotoxicity of 1,2-dichloroethane (EDC)

Keywords: CYP450، سیتوکروم P450; CYP450, cytochrome P450; EDC, 1,2-dichloroethane; GSH, glutathione; GST, glutathione-S-transferase1,2-Dichloroethane; Genotoxicity; Mutagenicity

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

CYP4F2 gene V433M polymorphism is associated with ischemic stroke in the male Northern Chinese Han population

Keywords: CYP450، سیتوکروم P450; AA, arachidonic acid; ACE, angiotensin converting-enzyme; ALOX5AP, 5-lipoxygenase activating protein; ApoE, apolipoprotein E; CYP450, cytochrome P450; CYP4F2, cytochrome P450, family 4, subfamily F, polypeptide 2; COX, cycloxygenase; β-Fg, beta-fibrinogen

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Antithrombotic Activity of the Novel Oral Anticoagulant, Tecarfarin [Sodium 3-[4-((1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yloxy) carbonyl) benzyl]-2-oxo-2H-chromen-4-olate] in Animal Models

Keywords: CYP450، سیتوکروم P450; aPTT, activated partial thromboplastin time; CYP450, cytochrome P450; INR, international normalized ratio; PT, prothrombin time; VKOR, vitamin K epoxide reductaseVitamin K antagonist; VKOR; Antithrombotic; Anticoagulant

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model

Keywords: CYP450، سیتوکروم P450; AA, arachidonic acid; t-AUCB, trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid; AUDA-BE, 12-(3-adamantan-1-yl-ureido)-dodecanoic acid butyl ester; COX, cyclooxygenase(s); CYP450, cytochrome P450; DHET, dihydroxyeicosatrienoic acid; EETs, e

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes

Keywords: CYP450، سیتوکروم P450; IL-6, interleukin-6; CYP450, cytochrome P450; PXR, pregnane X receptor; hPXR, human pregnane X receptor; LPS, lipopolysaccharide; TNF-α, tumor necrosis factor α; DRB, 5,6-dichlororibosidyl-benzimidazole; GAPDH, glyceradehyde-3-phosphate dehydrogenase; PCR

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Effect of in vivo nicotine exposure on chlorpyrifos pharmacokinetics and pharmacodynamics in rats

Keywords: CYP450، سیتوکروم P450; OP, organophosphorus; CPF, chlorpyrifos; CPF-oxon, chlorpyrifos-oxon; TCPy, 3,5,6-trichloro-2-pyridinol; AChE, acetylcholinesterase; ChE, cholinesterase; CYP450, cytochrome P450; AUC, area-under-the-curve; PON-1, paroxonase-1; sc, subcutaneous; PBPK/PD, p

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Impact of genetic and acquired alteration in cytochrome P450 system on pharmacologic and clinical response to clopidogrel

Keywords: CYP450، سیتوکروم P450; Clopidogrel; Polymorphism; Cytochrome P450; Proton pump inhibitorACS, acute coronary syndromes; AOR, adjusted odds ratio; ADP, adenosine diphosphate; CCB, calcium-channel blocker; CI, confidence interval; CYP450, cytochrome P450; HR, hazard ratio; LTA, li

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

The glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 has broad substrate specificity: Physiological and toxicological considerations

Keywords: CYP450، سیتوکروم P450; 11β-HSD, 11β-hydroxysteroid dehydrogenase; AKR, aldo-keto reductase; CYP450, cytochrome P450; ER, endoplasmic reticulum; G6P, glucose-6-phosphate; G6PT, endoplasmic reticulum glucose-6-phophate transporter; GR, glucocorticoid receptor; H6PDH, hexose-6-pho

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo

Keywords: CYP450، سیتوکروم P450; CYP450, cytochrome P450; HBSS, Ca2+- and Mg2+-free Hank’s buffered salt solution; DMEM, Dulbecco’s minimal essential medium; FCS, foetal calf serum; BSA, bovine serum albumin; DEX, dexamethasone; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium b

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions

Keywords: CYP450، سیتوکروم P450; CAR, constitutive androstane receptor; Cy3-CTP, cyanine 3-cytosine triphosphate; Cy5-CTP, cyanine 5-cytosine triphosphate; CYP450, cytochrome P450; DMSO, dimethyl sulfoxide; FCS, fetal calf serum; IPA, Ingenuity Pathways Analysis; PB, phenobarbital; PCA,

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Monocrotaline pyrrol is cytotoxic and alters the patterns of GFAP expression on astrocyte primary cultures

Keywords: CYP450، سیتوکروم P450; CNS, central nervous system; CYP450, cytochrome P450; DHMC, dehydromonocrotaline; DMF, dimethylformamide; GFAP, glial fibrillary acid protein; IF, intermediate filaments; LDH, lactate dehydrogenase; MCT, monocrotaline; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Effects of coffee and its chemopreventive components kahweol and cafestol on cytochrome P450 and sulfotransferase in rat liver

Keywords: CYP450، سیتوکروم P450; BROD, benzyloxyresorufin O-debenzylase; CYP450, cytochrome P450; EROD, ethoxyresorufin O-deethylase; GCS, γ-glutamylcysteine-synthetase; GSH, glutathione; GST, glutathione-S-transferase; K/C, kahweol and cafestol; MGMT, O6-methylguanine-DNA methyltransfer

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

trans-Arachidonic acids induce a heme oxygenase-dependent vasorelaxation of cerebral microvasculature

Keywords: CYP450، سیتوکروم P450; CYP450, Cytochrome P450; NOS, Nitric oxide synthase; HO, Heme oxygenase; PG, Prostaglandin; TAA, trans-arachidonic acid; NO2·, Nitrogen dioxide; cGMP, Cyclic 3′:5′-guanosine monophosphate; sGC, Soluble guanylyl cyclase; BKCa, Large conductance calcium-dep

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه