Co-administration with simvastatin or lovastatin alters the pharmacokinetic profile of sinomenine in rats through cytochrome P450-mediated pathways
Keywords: RA; rheumatoid arthritis; CV; cardiovascular; CYP enzyme; cytochrome P450 enzyme; DDI; drug-drug interaction; RLMs; rat liver microsomes; IS; internal standard; Sinomenine (PubChem CID: 5459308); Simvastatin (PubChem CID: 54454); Lovastatin (PubChem CID: