Keywords: AA; Arachidonic acid; AhR; Aryl hydrocarbon receptor; BBB; Blood-brain barrier; cDNA; Complementary DNA, deoxyribonucleic acid; CNS; Central nervous system; CP; Chlorpyrifos; CPO; Chlorpyrifos-oxon; CPR; Cytochrome p450 reductase; CYP; Cytochrome P450; EE
مقالات ISI (ترجمه نشده)
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Keywords: Direct infusion; Quantification; Single ion monitoring (SIM); Q Exactive; Cytochrome P450 (CYP)
Keywords: Letrozole; Medaka (Oryzias latipes); Cytochrome P450 (CYP); Aromatase inhibitor;
N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole
Keywords: Metamizole; N-methyl-4-aminoantipyrine; N-demethylation; Cytochrome P450 (CYP); Myeloperoxidase;
Effects of Baoyuan decoction, a traditional Chinese medicine formula, on the activities and mRNA expression of seven CYP isozymes in rats
Keywords: BYD; Baoyuan decoction; TCM; traditional Chinese medicine; CYP; cytochrome P450; HDI; herb-drug interaction; IS; internal standard; RT-PCR; real-time reverse transcription-polymerase chain reaction; QC; quality control; ESI; electrospray ionization; RSD;
Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics
Keywords: ADH; alcohol dehydrogenase; CDC; Centers for Disease Control and Prevention; CYP; cytochrome P450; del; deletion; EDDP; 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine; EM; extensive metabolizer; EMDP; 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline; FDA; Food and
Ultraviolet B radiation induces impaired lifecycle traits and modulates expression of cytochrome P450 (CYP) genes in the copepod Tigriopus japonicus
Keywords: UV-B radiation; Cytochrome P450 (CYP); Copepod; Tigriopus japonicus;
Marine copepod cytochrome P450 genes and their applications for molecular ecotoxicological studies in response to oil pollution
Keywords: Cytochrome P450 (CYP); copepod; Tigriopus japonicus; Paracyclopina nana; Water accommodated fraction (WAF);
Inducing rat brain CYP2D with nicotine increases the rate of codeine tolerance; predicting the rate of tolerance from acute analgesic response
Keywords: Codeine phosphate (PubChem CID: 5359227); Dextromethorphan hydrobromide (PubChem CID: 5464025); Morphine sulfate (PubChem CID: 16051935); Nicotine bitartrate (PubChem CID: 6708476); Propranolol hydrochloride (PubChem CID: 62882); Cytochrome P450 (CYP); To
Developmental exposures to an azole fungicide triadimenol at environmentally relevant concentrations cause reproductive dysfunction in females of medaka fish
Keywords: Triadimenol; Triadimenfon; Medaka (Oryzias latipes); Cytochrome P450 (CYP); Developmental toxicity; Reproductive toxicity;
Isolation of the monooxygenase complex from Rhipicephalus (Boophilus) microplus - clues to understanding acaricide resistance
Keywords: Cytochrome P450 (CYP); Cytochrome P450 oxidoreductase (CPR); Cytochrome b5; Rhipicephalus microplus; Pesticide resistance;
Pharmacogenetics and Personalized Medicine in Pain Management
Keywords: Pharmacogenetics; Polymorphism; Cytochrome P450 (CYP); Genomic testing; Pain management;
Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1
Keywords: CCM; Cerebral Cavernous Malformation; CHM; common hispanic mutation; ICH; intracerebral hemorrhage; CYP; cytochrome P450; MMP; matrix metalloproteinase; ROS; reactive oxygen species; ECM; extracellular matrix; NVU; neurovascular unit; BBB; blood-brain b
The enhancement of cardiac toxicity by concomitant administration of Berberine and macrolides
Keywords: hERG; Cytochrome P450 (CYP); Berberine (BBR); Azithromycin (AZM); Clarithromycin (CLR); Cardiac toxicity;
Characterization and sexual dimorphic expression of Cytochrome P450 genes in the hypothalamic-pituitary-gonad axis of yellow catfish
Keywords: Cytochrome P450 (CYP); Pelteobagrus fulvidraco; Phylogenetic analysis; Sexual dimorphism; Hormone treatment;
Investigation of cytochrome P450 inhibitory properties of maslinic acid, a bioactive compound from Olea europaea L., and its structure-activity relationship
Keywords: Cytochrome P450 (CYP); Olea europaea; Maslinic acid; Oleanolic acid; Pentacyclic triterpenes.;
Inhibitory effects of celastrol on rat liver cytochrome P450 1A2, 2C11, 2D6, 2E1 and 3A2 activity
Keywords: Celastrol; Cytochrome P450 (CYP); Competitive inhibitor; Mixed-type inhibitor
Rational design of novel CYP2A6 inhibitors
Keywords: Cytochrome P450 (CYP); CYP2A6; Nicotine; Inhibition; Smoking reduction therapy;
Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker
Keywords: Profenofos; 4-Bromo-2-chlorophenol (BCP); Cytochrome P450 (CYP); Pooled human liver microsomes; Recombinant human CYPs;
Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: A source of excessive hydroxy-estrogens and ROS?
Keywords: Cytochrome P450 (CYP); Catechol-O-methyltransferase (COMT); NAD(P)H:quinone oxidoreductase 1 (NQO1); (NRH):quinone oxidoreductase 2 (NQO2); Glutathione S-transferase pi 1 (GSTP1); Sulfotransferases (SULTs);
Prediction of sites of metabolism in a substrate molecule, instanced by carbamazepine oxidation by CYP3A4
Keywords: Cytochrome P450 (CYP); Carbamazepine (CBZ); Sites of metabolism (SOM); Molecular dynamics simulation; Multiple initial structures;
Overview of strategies for addressing BRIs in drug discovery: Impact on optimization and design
Keywords: CYP; cytochrome P450; DIT; drug-induced toxicity; GSH; reduced glutathione; LC-MS/MS; liquid chromatography-tandem mass spectrometry; PCB; protein covalent binding; Cytochrome P450 (CYP); Drug design; Reactive metabolites;
Inhibition of human drug metabolizing cytochrome P450 enzymes by plant isoquinoline alkaloids
Keywords: Corydalis cava; Papaveraceae; Isoquinoline alkaloids; Cytochrome P450 (CYP); Inhibition; Fluorometric assay
Role of zebrafish cytochrome P450 CYP1C genes in the reduced mesencephalic vein blood flow caused by activation of AHR2
Keywords: Aryl hydrocarbon; β-naphthoflavone (BNF); Blood flow; Cytochrome P450 (CYP); 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); Zebrafish embryo;
Comparison of warfarin sensitivity between rat and bird species
Keywords: Avian; Cytochrome P450 (CYP); Inhibitor constant (Ki); Raptor; Vitamin K epoxide reductase (VKOR); Vitamin K; Warfarin
Pharmacogenetics in palliative care
Keywords: Analgesia; Pain; Cytochrome P450 (CYP); Opioids; Tamoxifen; Polymorphism
In vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L. by anti-oxidant activity and inhibition of selected cytochrome P450 enzymes
Keywords: Fucus vesiculosus; Fucaceae; Fucophlorethols; Phlorotannin; Anti-oxidant; Radical-scavenging; Phloroglucinol; Cytochrome P450 (Cyp); Aromatase; Chemoprevention;
Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR)
Keywords: Constitutive androstane receptor (CAR); Nonylphenol; Cytochrome P450 (CYP); Sexually dimorphic; Liver
Analysis of CYP2D6 substrate interactions by computational methods
Keywords: Cytochrome P450 (CYP); Automated docking; Homology modelling; Molecular dynamics (MD); Site-directed mutagenesis
1,25-Dihydroxyvitamin D3 regulates genes responsible for detoxification in intestine
Keywords: Vitamin D and intestine; VDR; Microarrays; Cytochrome P450 (CYP); Phase I and phase II biotransformation
Functional characterization of human and cynomolgus monkey cytochrome P450 2E1 enzymes
Keywords: Cytochrome P450 (CYP); CYP2E1; Chlorzoxazone 6-hydroxylation; 4-Nitrophenol 2-hydroxylation; Primates; Human; Cynomolgus monkey
Herbicide resistance of transgenic rice plants expressing human CYP1A1
Keywords: Cytochrome P450 (CYP); Xenobiotic metabolism; Herbicide resistance; Atrazine; Chlorotoluron; Norflurazon; Phytoremediation; Detoxification
Metabolism of pyrene by aquatic crustacean, Daphnia magna
Keywords: Daphnia magna; Pyrene; Metabolism; Sulfate conjugation; Sulfotransferase (SULT); Cytochrome P450 (CYP)
Cytochrome P450 (CYP) inhibition screening: Comparison of three tests
Keywords: Cytochrome P450 (CYP); Inhibition; Human liver microsomes; Recombinant enzymes; In vitro cocktail; Fluorescent probes; Sotalol; Propranolol; Citalopram; Fluoxetine; Oxazepam; Diazepam
cDNA cloning and characterization of feline CYP1A1 and CYP1A2
Keywords: Cat; Cytochrome P450 (CYP); CYP1A1; CYP1A2;
Accessions of Solanum tuberosum ssp. andigena show differences in photosynthetic recovery after drought stress as reflected in gene expression profiles
Keywords: Anthocyanin; Basic leucine zipper (bZIP); Cytochrome P450 (CYP); Histone deacetylase; Metallothionein; Small heat shock protein
In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations in Human Liver Microsomes: a Comparison with SKF-525A
Keywords: Cytochrome P450 (CYP); human liver microsomes; 1-aminobenzotriazole (ABT); SKF-525A;
In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes
Keywords: Compound A; 5-{4-[3-(4-Cyclohexyl-2-propylphenoxy)propoxy]phenyl}-1,3-oxazolidine-2,4-dione; Cytochrome P450 (CYP); Liquid chromatography (LC); Mass spectrometry (MS); Nuclear magnetic resonance (NMR); Peroxisome proliferator-activated receptor (PPAR);
Role of tumor necrosis factor-α in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin
Keywords: Tumor necrosis factor-α (TNF-α); Cytochrome P450 (CYP); P-glycoprotein; Endotoxin; TNF-α knockout mice;
Cytochrome P450 2E polymorphism in feline liver
Keywords: Cat; Cytochrome P450 (CYP); CYP2E1; CYP2E2; Polymorphism;