High-dose supplementation with natural α-tocopherol does neither alter the pharmacodynamics of atorvastatin nor its phase I metabolism in guinea pigs
Keywords: ATV, atorvastatin; CEHC, carboxyethyl hydroxychromanol; CYP, cytochrome P450; HFC, high-fat control; OATP C, organic anion-transporting peptide C; T, tocopherolAtorvastatin; Cholesterol; Cytochrome P450 expression; Metabolites; Nutrient–drug interactions;