Keywords: Microglia; Stress; Alzheimer's disease; Neurodegeneration; Neuroinflammation; Synaptic remodeling; Microglial phenotypes; Dark microglia; Aβ; Amyloid beta; ABCA7; ATP-binding cassette transporter A7; AD; Alzheimer's disease; APOE; Apolipoprotein E; APP;
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Keywords: BHI; Brain Heart Infusion; DAP12; DNAX-activating protein of 12 kDa; DAPI; 4â²,6-diamidino-2-phenylindole; IFN-α; interferon-α; mAb; monoclonal antibody; MDMs; monocyte-derived macrophages; Siglec; sialic acid-binding Ig-like lectin; Sn; sialoadhesin;
Keywords: 2-DG; 2-deoxy glucose; Akt; protein kinase B; ARDS; acute respiratory distress syndrome; Arg; arginase; BALF; broncho-alveolar lavage fluid; BCG; Bacillus Calmette-Guérin; CD; cluster of differentiation; cGAS; cyclic GMP-AMP synthase; COX-2; cyclooxyge
Keywords: TREM2; triggering receptor expressed on myeloid cells-2; DC; dendritic cell; DAP12; DNAX-activation protein 12; sTREM2; soluble TREM2; AD; Alzheimer's disease; NHD; Nasu-Hakola disease; LOAD; late-onset AD; MS; multiple sclerosis; Aβ; amyloid beta; CNS
Keywords: BDNF; brain-derived neurotrophic factor; casp8; caspase 8; Cox-2; cyclooxygenase-2; CXCL1; chemokine (C-X-C motif) ligand 1; CX3CR1; CX3C chemokine receptor 1; DAP12; DNAX-activation protein 12; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; HMGB1; high
Keywords: Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange
Heterozygous TYROBP deletion (PLOSLFIN) is not a strong risk factor for cognitive impairment
Keywords: Genetics; Alzheimer's disease; Dementia; TYROBP; DAP12; PLOSL;
Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice
Keywords: Chemotherapeutic neuropathy; Cisplatin; Microglial activation; TREM2; DAP12;
Research articleADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157
Keywords: TREM2; Triggering receptor expressed on myeloid cells; AA; amino acids; DAP12; DNAX activating protein 12; ADAM1; a disintegrin and metalloproteinase domain containing protein; TACE; TNFα converting enzyme; Shedding; Alzheimers disease; Macrophages; Neur
Measles virus nucleocapsid protein modulates the Signal Regulatory Protein-β1 (SIRPβ1) to enhance osteoclast differentiation in Paget's disease of bone
Keywords: Paget's disease of bone; Osteoclast; MVNP; DAP12; SIRPβ1;
N-glycan and Alzheimer's disease
Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; APOE; apolipoprotein E; APP; amyloid precursor protein; BACE1; β-site APP cleaving enzyme-1; DAP12; DNAX-activating protein of 12 kD; GnT-III; N-acetylglucosaminyltransferase-III; NFT; neurofibrillary tangle; PS
Immunoreceptors on neutrophils
Keywords: ADCC; antibody-dependent cellular cytotoxicity; ANCAs; anti-neutrophil autoantibodies; Btk; Bruton's tyrosine kinase; DAG; diacyl-glycerol; DAP12; DNAX activation protein of 12Â kDa; ERK; extracellular signal-regulated kinase; fMLP; N-Formylmethionine-leu
The Paracaspase MALT1
Keywords: NF-κB signaling; Protease; Caspase; Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1); ABC; activated B cell-like; ABC-DLBCL; activated B cell-like diffuse large B cell lymphoma; Ac; acetyl; ALL; acute lymphomblastic leukemia; AM
Original Full Length ArticleSialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) mediates periarticular bone loss, but not joint destruction, in murine antigen-induced arthritis
Keywords: AIA; antigen-induced arthritis; DAP12; DNAX-activating protein 12 kDa; FcRγ; Fc receptor common γ; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; ITAM; immunoreceptor tyrosine-based activation motif; mBSA; methylated bovine serum albumin; micro-CT; m
ReviewWhat happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic?
Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase domain-containing protein; CpG DNA; cytosine-phosphate-guanidine deoxynucleic acid; CSF; cerebrospinal fluid; CTF; C-terminal fragment; DAP12; DNAX-activating protein
The C9ORF72 expansion does not affect the phenotype in Nasu-Hakola disease with the DAP12 mutation
Keywords: Polycystic lipomembranous osteodysplasia and sclerosing leukoencephalopathy; TYROBP; DAP12; TREM2; C9ORF72; Frontotemporal dementia; Epilepsy;
Sex differences in murine susceptibility to systemic viral infections
Keywords: Female; IFNαβ; DAP12; HSV; MCMV; Vaccinia; Survival;
Fyn positively regulates the activation of DAP12 and FcRγ-mediated costimulatory signals by RANKL during osteoclastogenesis
Keywords: Fyn; Costimulatory signal; FcRγ; DAP12; Osteoclast; Differentiation;
Involvement of the TREM-1/DAP12 pathway in the innate immune responses to Porphyromonas gingivalis
Keywords: TREM-1; Triggering Receptor Expressed on Myeloid cells 1; DAP12; DNAX activating protein of 12Â kDa; qPCR; quantitative real-time polymerase chain reaction; TLR; Toll-like receptor; IL; interleukin; TREM-1; DAP12; LP17; MonoMac-6; Porphyromonas gingivalis
Involvement of human endogenous retroviral syncytin-1 in human osteoclast fusion
Keywords: OC(s); osteoclast(s); TRACP; tartrate resistant acid phosphatase; MIP-1α; macrophage inflammatory protein 1α; MT1-MMP; membrane type-1 matrix metalloproteinase; SIRP1α; signaling regulatory protein 1α; DAP12; DNAX-activating protein of molecular mass
No evidence for shared etiology in two demyelinative disorders, MS and PLOSL
Keywords: MS; PLOSL; DAP12; TREM2; Association
Form, function and phylogenetics of NITRs in bony fish
Keywords: Teleost; Innate immunity; Natural killer receptors; ITIM; ITSM; DAP12; CD8; KIR
A novel compound heterozygous mutation in the DAP12 gene in a patient with Nasu-Hakola disease
Keywords: Compound heterozygote; DAP12; Loss of function mutations; TYROBP; Nasu-Hakola disease
Structural characteristics of zebrafish orthologs of adaptor molecules that associate with transmembrane immune receptors
Keywords: FcR; Fc receptor; Ig; immunoglobulin; ITAM; immunoreceptor tyrosine-based activation motif; ITIM; immunoreceptor tyrosine-based inhibition motif; NK; natural killer; TCR; T-cell antigen receptor.DAP10; DAP12; FcRγ; CD3ζ
ITAM-based signaling beyond the adaptive immune response
Keywords: ITAM; Syk; Adaptive immunity; Innate immunity; DAP12; Fc-receptor γ-chain; Platelets; Osteoclasts; NK-cells; Neutrophils; Macrophages; Dendritic cells
Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: Continuous shuttling to and from the plasma membrane regulated by cell stimulation
Keywords: regulated exocytosis; endocytosis; regulated recycling; membrane traffic; PLOSL; BSA; bovine serum albumin; [Ca2+]; concentration of Ca2+; DAPI; 4â²,6-diamidino-2-phenylindole; DAP12; DNAX-activating protein of 12 kDa (DAP12), also called killer cell act
Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS
Keywords: Neurodegeneration; Innate immunity; Microglia; Activating receptor; DAP12; TREM2;