
Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment
Keywords: AKR; aldo-keto reductase; CDK; cyclin-dependent kinase; CI; combination index; Dau; daunorubicin; Dau-ol; daunorubicinol; DOX; doxorubicin; DMSO; dimethyl sulfoxide; Fa; fraction affected; HCT116-AKR1C3; cells transfected with pCI_AKR1C3; HCT116-EV; cells