Keywords: DEN، دیاتیلنتایرواسمین; Fatty liver disease; Liver cancer; Western diet; Broccoli; DiethylnitrosamineAHF, altered hepatic foci; ALT, alanine aminotransferase; AMPK, 5' AMP-activated protein kinase; Cyp, cytochrome P450; DEN, diethylnitrosamine; GAPDH, glyceraldehyde 3-phosphate
مقالات ISI DEN، دیاتیلنتایرواسمین (ترجمه نشده)
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Keywords: DEN، دیاتیلنتایرواسمین; AFP, alpha fetoprotein; ALP, alkaline phosphatase; BCLC, Barcelona-Clinic Liver Cancer; CLIP, Cancer of the Liver Italian Program; DEN, diethylnitrosamine; GEO, Gene Expression Omnibus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; TCA, tricarbox
Keywords: DEN، دیاتیلنتایرواسمین; 2-AAF, 2-acetylaminofluorene; ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; DEN, diethylnitrosamine; EDTA, ethylenediamine tetraacetic acid; eNOS, endothelial nitric oxide synthase; GGT, gamma-glutamyl transfera
Keywords: DEN، دیاتیلنتایرواسمین; 1-D, one-dimensional; CPMG, Carr-Purcell-Meiboom-Gill 3B; DEN, diethylnitrosamine; FID, free induction decay; 1H, human proton; HCC, hepatocellular carcinoma; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NOESY, nuclear overhauser effect sp
Keywords: DEN، دیاتیلنتایرواسمین; RCC, Renal cell carcinoma; DEN, Diethylnitrosamine; Fe-NTA, Ferric nitilotriacetate; GPx, glutathione peroxidase; GSH, glutathione; GR, glutathione reductase; GST, glutathione-S-transferase; LPO, lipid peroxidation; MDA, malondialdehyde; PMS, post-mitocho
ADRB2 signaling promotes HCC progression and sorafenib resistance by inhibiting autophagic degradation of HIF1α
Keywords: DEN، دیاتیلنتایرواسمین; ADRB2, beta-2 adrenergic receptor; HCC, hepatocellular carcinoma; DEN, diethylnitrosamine; FOR, formoterol; HIF1α, hypoxia-inducible factor α; IHC, immunohistochemistryBeta-2 adrenergic receptor; Liver cancer; Autophagy; Sorafenib resistance
Hepatitis C virus suppresses Hepatocyte Nuclear Factor 4 alpha, a key regulator of hepatocellular carcinoma
Keywords: DEN، دیاتیلنتایرواسمین; AP, acute phase; APR, acute phase response; C3, complement component 3; DEN, diethylnitrosamine; FBG-β, fibrinogen beta; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; HNF1α, hepatocyte nuclear factor 1 alpha; HNF4α, hepatocyte nuclear factor 4 al
Effect of alcohol on diethylnitrosamine-induced hepatic toxicity: Critical role of ROS, lipid accumulation, and mitochondrial dysfunction
Keywords: DEN، دیاتیلنتایرواسمین; ADH, alcohol dehydrogenase; ALT, alanine transaminase; AST, aspartate transaminase; CYP2E1, cytochrome P4502E1; DEN, diethylnitrosamine; FFA, free fatty acids; HCC, hepatocellular carcinoma; HSCs, hepatic stellate cells; MPTP, mitochondrial permeability t
A medium-term gpt delta rat model as an in vivo system for analysis of renal carcinogenesis and the underlying mode of action
Keywords: DEN، دیاتیلنتایرواسمین; Medium-term animal model; Chemical carcinogenicity; Kidney; gpt Delta rat; In vivo mutagenicity; Tumor-promoting activityUN, unilateral nephrectomy; PH, partial hepatectomy; GST-P, glutathione S-transferase placental form; DEN, diethylnitrosamine; AT, aty
Genetic polymorphism of interleukin-6 influences susceptibility to HBV-related hepatocellular carcinoma in a male Chinese Han population
Keywords: DEN، دیاتیلنتایرواسمین; AFP, α-fetoprotein; ALB, albumin; ALT, alanine aminotransferase; CI, confidence interval; CT, computed tomography; DEN, diethylnitrosamine; HBcAb, hepatitis B virus core antibody; HBeAb, hepatitis B virus e antibody; HBeAg, hepatitis B virus e antigen; HB
Laser capture microdissection after γ-glutamyl transferase histochemistry: An optimization for gene expression analysis
Keywords: DEN، دیاتیلنتایرواسمین; GGT, γ-glutamyl transferase; GMNA, γ-glutamyl-4-methoxy-2-naphthylamide; LCM, laser capture microdissection; qRT–PCR, quantitative reverse transcriptase polymerase chain reaction; DEN, diethylnitrosamine; 2AAF, 2-acetylaminofluorene; DEPC, diethylpyrocarb
Improvement and validation of a medium-term gpt delta rat model for predicting chemical carcinogenicity and underlying mode of action
Keywords: DEN، دیاتیلنتایرواسمین; PH, partial hepatectomy; GST-P, glutathione S-transferase placental form; CYP, cytochrome P450; i.p., intraperitoneal; DEN, diethylnitrosamine; DADS, diallyl disulfide; PBO, piperonyl butoxide; PHE, phenytoin; ES, estragole; AA, aristolochic acid; BNF, β-
Inter-laboratory comparison of turkey in ovo carcinogenicity assessment (IOCA) of hepatocarcinogens
Keywords: DEN، دیاتیلنتایرواسمین; FAH, foci of altered hepatocytes; IOCA, in ovo carcinogenicity assessment; DEN, diethylnitrosamine; NNK, 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCarcinogenesis; Histopathology; Liver; Preneoplasia; Preclinical safety-assessment; Risk identifica
Panax ginseng exerts antiproliferative effects on rat hepatocarcinogenesis
Keywords: DEN، دیاتیلنتایرواسمین; DAVID, Database for Annotation, Visualization, and Integrated Discovery; DAB, 3,3′-diaminobenzidine; DEN, diethylnitrosamine; GS, Panax ginseng CA Meyer; GST-P–positive foci, glutathione S-transferase P form–positive foci; JN, Panax japonicus CA Meyer; PC
p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression
Keywords: DEN، دیاتیلنتایرواسمین; 4-HNE, 4-hydroxynonenal; ActD, actinomycin D; BAD, Bcl-2 antagonist of cell death; DEN, diethylnitrosamine; H&E, hematoxylin and eosin; HSP27, heat shock protein 27; IL, interleukin; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; MP
Nanocapsulated curcumin: Oral chemopreventive formulation against diethylnitrosamine induced hepatocellular carcinoma in rat
Keywords: DEN، دیاتیلنتایرواسمین; Cur, curcumin; PLGA, polylactide co-glycolide; Nano Cur, Nanocapsulated curcumin; HCC, hepatocellular carcinoma; DEN, diethylnitrosamine; FTIR, Fourier Transform Infra Red; ROS, reactive oxygen species; EPR, enhanced permeability and retention effect; BSA
A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches
Keywords: DEN، دیاتیلنتایرواسمین; MAPK; Hepatocellular Carcinoma; Insulin Resistance; c-Jun; TNF; AcetaminophenAP, activator protein; ASK, apoptosis signal-regulating kinase; ATF, activating transcription factor; cIAP, cellular inhibitor of apoptosis; DEN, diethylnitrosamine; EGF, epiderm
Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a
Keywords: DEN، دیاتیلنتایرواسمین; 5-aza-dC, 5-aza-2′-deoxycytidine; CIS, carcinoma in situ; DEN, diethylnitrosamine; DNMTs, DNA methyltransferases; MCA, 3-methylcholanthrene; MSP, methylation-specific polymerase chain reaction; NSCLC, non-small cell lung cancer; RT-PCR, reverse transcript
Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats
Keywords: DEN، دیاتیلنتایرواسمین; DEN, diethylnitrosamine; qRT-PCR, quantitative real-time-polymerase chain reaction; HCC, hepatocellular carcinoma; GST, glutathione-S-transferase; PCNA, proliferating cell nuclear antigenNeoplastic nodules; Chemoprevention; Chrysin; Apoptosis; Diethylnitr
RB and p53 Cooperate to Prevent Liver Tumorigenesis in Response to Tissue Damage
Keywords: DEN، دیاتیلنتایرواسمین; Liver Cancer; Mouse Model; Genetics; Tumor Environment; DENCGH, comparative genomic hybridization; DEN, diethylnitrosamine; PCR, polymerase chain reaction; p-γH2AX, phospho-γH2AX; RB, retinoblastoma
BRE over-expression promotes growth of hepatocellular carcinoma
Keywords: DEN، دیاتیلنتایرواسمین; BRE, brain and reproductive organ-expressed; TNFRSF1A, tumor necrosis factor receptor superfamily member 1A; BRCC45, BRCA1/2-containing complex subunit 45; HCC, hepatocellular carcinoma; DEN, diethylnitrosamine; DISC, death-inducing signaling complex; TTR
CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine
Keywords: DEN، دیاتیلنتایرواسمین; CIS, carcinoma in situ; DEN, diethylnitrosamine; MCA, 3-methylcholanthrene; MSP, methylation-specific polymerase chain reaction; TSGs, tumor suppressor genes3-Methylcholanthrene; Diethylnitrosamine; DNA methylation; Carcinogenesis; Lung cancer; Tumor supp
Morin fosters apoptosis in experimental hepatocellular carcinogenesis model
Keywords: DEN، دیاتیلنتایرواسمین; DEN, diethylnitrosamine; HCC, hepatocellular carcinoma; ppm, parts per million; LY294002, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; TBS-T, Tris-buffered saline with 0.2% Tween 20; EDTA, ethylenediaminetetraacetate; HL-60, human promyelocytic leuke
Chemopreventive effects of 13α,14α-epoxy-3β-methoxyserratan-21β-ol (PJJ-34), a serratane-type triterpenoid, in a rat multi-organ carcinogenesis bioassay
Keywords: DEN، دیاتیلنتایرواسمین; PJJ-34; Serratane-type triterpenoid; Chemoprevention; Rat; Multi-organ carcinogenesisBBN, N-butyl-N-(4-hydroxy-butyl)nitrosamine; DEN, diethylnitrosamine; DHPN, 2,2′-dihydroxy-di-N-propylnitrosamine; DMH, 1,2-dimethylhydrazine dihydrochloride; GST-P, glut
Targeted deletion of hepatocyte Ikkβ confers growth advantages
Keywords: DEN، دیاتیلنتایرواسمین; Ikkβ, IκB kinase β; IKK, IκB kinase complex; PH, partial hepatectomy; DEN, diethylnitrosamine; HCC, hepatocellular carcinoma; ECM, extracellular matrix; TGF, transforming growth factor; PBS, phosphate-buffered saline; GFP, green fluorescent protein; FAK,
Morin regulates the expression of NF-κB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma
Keywords: DEN، دیاتیلنتایرواسمین; DEN, diethylnitrosamine; HCC, hepatocellular carcinoma; MMPs, matrix metalloproteinases; COX, cyclooxygenase; NF-κB, nuclear factor kappa B; PG, prostaglandin; kDa, kilodaltons; DAB, 3,3-diaminobenzidine tetrahydrochloride; TBS-T, tris-buffered saline wit
Tumor promoting and co-carcinogenic effects in medium-term rat hepatocarcinogenesis are not modified by co-administration of 12 pesticides in mixture at acceptable daily intake
Keywords: DEN، دیاتیلنتایرواسمین; ADI, acceptable daily intake; GGT, γ-glutamyl transpeptidase; GSTP, glutathione S-transferase P; NOAEL, non-observed adverse effects level; HCC, hepatocellular carcinoma; DEN, diethylnitrosamine; 2AAF, 2-acetylaminofluorene; PH 70%, partial hepatectomy; A
Enhancement of preneoplastic lesion yield by Chios Mastic Gum in a rat liver medium-term carcinogenesis bioassay
Keywords: DEN، دیاتیلنتایرواسمین; BrdU, 5-bromo-2′-deoxyuridine; CMG, Chios Mastic Gum; CYP, cytochrome P450; DEN, diethylnitrosamine; GST-P, glutathione S-transferase placental form; 8-OHdG, 8-hydroxydeoxyguanosine; PCR, polymerase chain reaction.Chios Mastic Gum; GST-P foci; Ito-test; R
Chemopreventive action of Lygodium flexuosum extract in human hepatoma PLC/PRF/5 and Hep 3B cells
Keywords: DEN، دیاتیلنتایرواسمین; ANOVA, analysis of variance; DEN, diethylnitrosamine; DMEM, Dulbecco's Modified Eagle Medium; DMSO, dimethyl sulfoxide; DTT, dithiothreitol; EDTA, ethylene diamine tetra acetic acid; EGFR, epidermal growth factor receptor; EGTA, ethylene glycol-bis (2-ami
Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesi
Keywords: DEN، دیاتیلنتایرواسمین; MeIQx, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; DEN, diethylnitrosamine; GST-P, glutathione S-transferase placental form; DMH, 1,2-dimethylhydrazine; DMBA, 7,12-dimethylbenz[a]anthracene; DHPN, 2,2′-dihydroxy-di-n-propylnitrosamine; ACF, aberrant cr
Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3′,4,4′-tetrachlorobiphenyl (PCB-77)
Keywords: DEN، دیاتیلنتایرواسمین; AAF, 2-acetylaminofluorene; ANOVA, analysis of variance; BrdU, bromodeoxyuridine; CoQ10, coenzyme CoQ10; DEN, diethylnitrosamine; EGCG, epigallocatechin-3-gallate; GC–MS, gas chromatography–mass spectrometry; Glu-P-1, 2-amino-6-methyldipyrido[1,2-a:3′,2′-
Vitamin A and β-carotene inhibitory effect during 1,2-dimethylhydrazine induced hepatocarcinogenesis potentiated by 5-azacytidine
Keywords: DEN، دیاتیلنتایرواسمین; 5-Azc, 5-azacytidine; DEN, diethylnitrosamine; 1,2-DMH, 1,2-dimethylhydrazine; γ-GT, γ-glutamyltranspeptidase; PNL, preneoplastic lesions; RH, resistant hepatocyte; 2-AAF, 2-acetylaminofluoreneHepatocarcinogenesis; 1,2-Dimethylhydrazine; 5-Azacytidine; Ch
The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats
Keywords: DEN، دیاتیلنتایرواسمین; BrdU, bromodeoxyuridine; BROD, benzyloxyresorufin O-dealkylase; DEN, diethylnitrosamine; EROD, Ethyoxyresorufin O-dealkylase; LPS, lipopolysaccaride; PCBs, polychlorinated biphenyls; PCB-153, 2,2′,4,4′,5,5′-hexachlorobiphenyl; PCB-77, 3,3′,4,4′-tetrachlor
RB Loss Abrogates Cell Cycle Control and Genome Integrity to Promote Liver Tumorigenesis
Keywords: DEN، دیاتیلنتایرواسمین; CIN, chromosomal instability; DEN, diethylnitrosamine; HCC, hepatocellular carcinoma; RB, retinoblastoma tumor suppressor
Sodium Iodide Symporter Is Expressed at the Preneoplastic Stages of Liver Carcinogenesis and in Human Cholangiocarcinoma
Keywords: DEN، دیاتیلنتایرواسمین; CCA, cholangiocarcinoma; DEN, diethylnitrosamine; HCC, hepatocellular carcinoma; IHC, immunohistochemistry; NIS, sodium iodide symporter; ROI, regions of interest; RT-PCR, reverse transcription polymerase chain reaction; SPECT/CT, single photon emission c
Time-dependent onset of Interferon-α2b-induced apoptosis in isolated hepatocytes from preneoplastic rat livers
Keywords: DEN، دیاتیلنتایرواسمین; IFN-α2b, interferon alfa-2b; TGF-β1, transforming growth factor β1; ROS, radical oxygen species; ΔΨ, transmembrane potential; DEN, diethylnitrosamine; 2-AAF, 2-acetylaminofluorene; DCFH-DA, 2′,7′-dichlorofluorescin diacetate; TMRM, tetramethylrhodamine me
Dietary sphingolipids suppress a subset of preneoplastic rat liver lesions exhibiting high PTEN, low phospho-Akt and high levels of ceramide species
Keywords: DEN، دیاتیلنتایرواسمین; GST-P, glutathione-S-transferase Pi; EAF, enzyme-altered foci; pAkt, phosphorylated Akt; DEN, diethylnitrosamine; pAkt−/cer+ EAF, pAkt-negative/ceramide-positive enzyme altered foci; PTEN, phosphatase and tensin homolog deleted on chromosome 10Sphingolipi
Deletion of the SOCS3 Gene in Liver Parenchymal Cells Promotes Hepatitis–Induced Hepatocarcinogenesis
Keywords: DEN، دیاتیلنتایرواسمین; AlbCre, albumin-Cre; Bcl-XL, B-cell lymphoma-XL; Bcl-2, B-cell lymphoma-2; C-Myc, c-myelocytomatosis; cKO, conditional knockout; DEN, diethylnitrosamine; ERK, extracellular regulated kinase; IL, interleukin; IRF, interferon regulatory factor; KO, knockout
Cyclooxygenase-2 in hepatocellular carcinoma
Keywords: DEN، دیاتیلنتایرواسمین; AA, arachidonic acid; COX-2, cyclooxygenase-2; cPLA2, cytosolic phospholipase A2; DEN, diethylnitrosamine; EGFR, epidermal growth factor receptor; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; HGF, hepatocyte growth factor