
Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase
Keywords: DHF, 7,8-dihydrofolate; DHFR, dihydrofolate reductase; HSQC, heteronuclear single-quantum correlation; ITC, isothermal titration calorimetry; Kd, dissociation constant; NMR, nuclear magnetic resonance; NADP+, nicotinamide adenine dinucleotide phosphate; N