
Ligand-based design, in silico ADME-Tox filtering, synthesis and biological evaluation to discover new soluble 1,4-DHP-based CFTR activators
Keywords: DHP; 3D-QSAR; ADME-Tox; CFTR potentiators; GRIND; VolSurf+CF, cystic fibrosis; CFTR, cystic fibrosis transmembrane conductance regulator; ADME-Tox, absorption distribution metabolism toxicity; DHP, 1,4-dihydropyridine; QSAR, quantitative structure–activit