
Keywords: Schistosoma mansoni; Nucleotide metabolism; Dihydrofolate reductase (DHFR); Isothermal titration calorimetry (ITC); X-ray crystallography; DHFR; dihydrofolate reductase; rSmDHFR; recombinant Schistosoma mansoni DHFR; NADPH and NADP+; nicotinamide adenine