Mechanism and Thermodynamics of Guanidinium Chloride-induced Denaturation of ALS-associated Mutant Cu,Zn Superoxide Dismutases
Keywords: superoxide dismutase; amyotrophic lateral sclerosis; protein stability and folding; dimeric protein; guanidine hydrochloride denaturationhSOD, human superoxide dismutase; ΔG, change in Gibbs free energy; m, dependence of ΔG unfolding on denaturant concent