دانلود مقالات ISI درباره DIPEA، N، N-Diisopropylethylamine + ترجمه فارسی

کوینازولین ها و کوینازولینون ها به عنوان بخش های ساختاری همه جا در شیمی دارویی: به روز رسانی در توسعه روش های مصنوعی و تنوع دارویی

Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological diversification

Keywords: DIPEA، N، N-Diisopropylethylamine; BPO, Benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate; BSA, bovine serum albumin; BZD, benzodiazepine; DBU, 1,8-diazabicycloundec-7-ene; DIPEA, N,N-Diisopropylethylamine; DMAD, dimethyl acetylenedicarboxylate; DNA, Deoxyribonucl

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2016 سفارش ترجمه

طراحی، سنتز و ارزیابی بیولوژیکی یک پلی اتیل مخزن انتخابی بسیار قوی و سلول سرطانی

Design, synthesis and biological evaluation of a highly-potent and cancer cell selective folate–taxoid conjugate

Keywords: DIPEA، N، N-Diisopropylethylamine; ATCC, American Type Culture Collection; CFM, confocal fluorescence microscopy; DIC, N,N′-diisopropylcarbodiimide; DIPEA, N,N-diisopropylethylamine; DMAP, 4-(dimethylamino)pyridine; DMEM, Dulbecco’s modified eagle’s medium; DMF, N,N-dimethylformamide; DMSO

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

ساختار، سنتز و ساختار فعالیت-رابطه مشتقات تتراهیدروتیازولوپیریدین به عنوان آنتاگونیست های قوی و خنثی

Design, synthesis, and structure–activity-relationship of tetrahydrothiazolopyridine derivatives as potent smoothened antagonists

Keywords: DIPEA، N، N-Diisopropylethylamine; Hedgehog signaling pathway; Smoothened; Antagonist; GPCR; Scaffold hopping; Cancer therapyAUC, area under curve; CE, collision energy; DCM, dichloromethane; DIPEA, N,N-diisopropylethylamine; DMF, N,N-dimethylformamide; DMSO, dimethyl sulfoxide; DP, declus

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

سنتز و ارزیابی اولیه 5،7-دی متیل-2-aryl-3H-pyrrolizin-3-them به عنوان مهارکننده های آنژیوژنز

Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors

Keywords: DIPEA، N، N-Diisopropylethylamine; HBTU, 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate; CSF-1R, colony-stimulating factor-1 receptor; DIPEA, N,N-diisopropylethylamine; FLT-3, Fms-like tyrosine kinase 3; FOV, field of view; HUVEC, human umbilical vein endothelial c

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis, and evaluation of Trolox-conjugated amyloid-β C-terminal peptides for therapeutic intervention in an in vitro model of Alzheimer’s disease

Keywords: DIPEA، N، N-Diisopropylethylamine; AA, amino acid; Aβ, amyloid-β; AD, Alzheimer’s disease; DCFH-DA, 2′,7′-dichlorodihydrofluorescein diacetate; DIPEA, N,N-diisopropylethylamine; DMF, N,N-dimethylformamide; DMSO, dimethyl sulfoxide; HBTU, O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium h

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations

Keywords: DIPEA، N، N-Diisopropylethylamine; ACN, acetonitrile; Boc, tert-butyloxycarbonyl; CHO, Chinese hamster ovary; DAMGO, [D-Ala2,NMePhe4,Gly5-ol]enkephalin; DALEA, [D-Ala2, Leu5] enkephalin amide; DCM, dichloromethane; DIPEA, N,N-diisopropylethylamine; HBTU, N,N,N′,N′-tetra methyl-O-(1H-benzot

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and evaluation of fac-[99mTc/Re(CO)3]+ complexes with a new (N,S,N) bifunctional chelating agent: The first example of a fac-[Re(CO)3(N,S,N-sst2-ANT)] complex bearing a somatostatin receptor antagonist peptide

Keywords: DIPEA، N، N-Diisopropylethylamine; Rhenium; Technetium; Tricarbonyl complexes; SPECT; Somatostatin receptor antagonistDCC, N,N′-Dicyclohexylcarbodiimide; DIPEA, N,N-Diisopropylethylamine; EDC, 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide; HBTU, N,N,N′,N'-Tetramethyl-O-(1H-benzotriazol-1-y

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Discovery of novel Tetrahydrobenzo[b]thiophene and pyrrole based scaffolds as potent and selective CB2 receptor ligands: The structural elements controlling binding affinity, selectivity and functionality

Keywords: DIPEA، N، N-Diisopropylethylamine; CB2 selective ligands; CB2 agonist; CB2 inverse agonist; CannabinoidsCB1, Cannabinoid receptor 1; CB2, Cannabinoid receptor 2; DIPEA, N,N-Diisopropylethylamine; EDC, 1-Ethyl-3-(3’-dimethylamino)carbodiimide HCl salt; HATU, 1-[Bis(dimethylamino)methylene]-

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

The natural, peptaibolic peptide SPF-5506-A4 adopts a β-bend spiral structure, shows low hemolytic activity and targets membranes through formation of large pores

Keywords: DIPEA، N، N-Diisopropylethylamine; Aib, α-aminobutyric acid; AMP, antimicrobial peptide; CD, circular dichroism; DIPEA, N,N-diisopropylethylamine; CLSM, confocal laser scanning microscopy; d22-DHPC, 1,2-dihexanoyl-d22-sn-glycero-3-phosphocholine; d54-DMPC, 1,2-dimyristoyl-d54-sn-glycero-3-

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

New macrocyclic analogs of the natural histone deacetylase inhibitor FK228; design, synthesis and preliminary biological evaluation

Keywords: DIPEA، N، N-Diisopropylethylamine; Boc-, tert-Butyloxycarbonyl-; DCM, dichloromethane; DIPEA, N,N-diisopropylethylamine; DMAP, 4-(dimethylamino)pyridine; DMF, N,N-dimethylformamide; DTT, dithiotreitol; Fmoc, fluorenyl-9-methyloxycarbonyl-; mGly, malonyl-glycine; HOBt, 1-hydroxy-benzotriazo

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A

Keywords: DIPEA، N، N-Diisopropylethylamine; Lysine demethylase; Tranylcypromine; EpigeneticBOC, t-butyloxycarbonyl; DIPEA, N,N-diisopropylethylamine; DMF, N,N-dimethyl formamide; DMSO, dimethylsulfoxide; HDAC, histone deacetylase; KDM1A, lysine-specific histone demethylase type 1; MAO, monoamine ox

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors

Keywords: DIPEA، N، N-Diisopropylethylamine; CYP, cytochrome P450; DCM, dichloromethane; DIPEA, N,N-diisopropylethylamine; DMF, N,N-dimethylformamide; DMSO, dimethyl sulfoxide; DSH, Dishevelled; HPLC, high performance liquid chromatography; mp, melting point; N-G-L, NIH3T3-GRE-Luc reporter gene assa

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)

Keywords: DIPEA، N، N-Diisopropylethylamine; 2-Nal, l-3-(2-naphthyl)alanine; CXCL12, CXC chemokine ligand 12; CXCR4, CXC chemokine receptor 4; DIPEA, N,N-diisopropylethylamine; EDC, N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide; HATU, 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridini

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: A novel class of irreversible inhibitors of histone demethylase KDM1A

Keywords: DIPEA، N، N-Diisopropylethylamine; Epigenetics; Histone lysine demethylases; Tranylcypromine; Antiproliferation; X-ray crystallographyLSD, lysine-specific histone demethylase; MAO, monoamine oxidase; DIPEA, N,N-diisopropylethylamine

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Anticancer activity of ruthenium(II) arene complexes bearing 1,2,3,4-tetrahydroisoquinoline amino alcohol ligands

Keywords: DIPEA، N، N-Diisopropylethylamine; Anticancer; Tetrahydroisoquinoline; RutheniumA549, human lung epithelial adenocarcinoma; atm, atmosphere; ATR, attenuated total reflectance; Cbz-Cl, benzyl chloroformate; DIPEA, N,N-diisopropylethylamine; DBU, 1,8- diazabicycloundec-7-ene; ESI-QTOF, elect

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis, structure–property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor

Keywords: DIPEA، N، N-Diisopropylethylamine; P2Y12 receptor; Anti-platelet; Sulfonylureas; Solubility; Stability3-aze, 3-amino-azetidinyl; CDI, N,N′-carbonyl diimidazole; CLint, intrinsic clearance; cy-Pr, cyclopropyl; Caco-2, adenocarcinoma cells from human colon; DIPEA, N,N-diisopropylethylamine;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Total synthesis and structure–activity relationships of new echinocandin-like antifungal cyclolipohexapeptides

Keywords: DIPEA، N، N-Diisopropylethylamine; Echinocandin; Caspofungin; Cyclolipohexapeptide; Total synthesis; Antifungal; SARHOBt, 1-hydroxybenzotrizole; MTBE, methyl tertiary butyl ether; EDC, 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide; TFA, rifluoroactic acid; DIPEA, N,N-diisopropylethylamine

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Design, synthesis and biological activity of novel peptidyl benzyl ketone FVIIa inhibitors

Keywords: DIPEA، N، N-Diisopropylethylamine; Activated factor VII; Serine protease inhibitor; Peptidyl benzyl ketone; C-Terminal modified peptide; Stabilization agentbk, benzyl ketone; DIPEA, N,N-diisopropylethylamine; FXa, activated Factor X; HOAt, 1-hydroxy-7-azabenzotrizole; HPLC-CLND, high perfo

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Structure–function relationship of conotoxin lt14a, a potential analgesic with low cytotoxicity

Keywords: DIPEA، N، N-Diisopropylethylamine; nAChR, nicotinic acetylcholine receptor; DMF, N,N-dimethylformamide; TFA, trifluoroacetic acid; HBTU, 2-(1H-benzotriazol-l-yl) 1,1,3,3-tetrametyluronium hexafluorophosphate; DIPEA, N,N-diisopropylethylamine; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylt

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

The inhibitor profiling of the caspase family of proteases using substrate-derived peptide glyoxals

Keywords: DIPEA، N، N-Diisopropylethylamine; Ac, acetyl; AFU, arbitrary fluorescence units; AMC, amidomethylcoumarin; BCA, bicinchoninic acid; BCIP, 5-bromo-4-chloro-3′-indolyphosphate p-toluidine salt; Cbz, carboxybenzyl; DIPEA, N,N-diisopropylethylamine; DMF, dimethylformamide; DTT, dithiothreitol

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Multivalent cyclic RGD ligands: influence of linker lengths on receptor binding

Keywords: DIPEA، N، N-Diisopropylethylamine; DCM, dichloromethane; DIC, N,N′-diisopropylcarbodiimide; DIPEA, N,N-diisopropylethylamine; DMF, N,N-dimethylformamide; EG, ethylene glycol; Fmoc, 9-fluorenylmethyloxycarbonyl; HBTU, 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis of novel dendrimers having aspartate grafts and their ability to enhance the aqueous solubility of model drugs

Keywords: DIPEA، N، N-Diisopropylethylamine; Dendrimers; Aspartic acid; Solubility enhancement; L-Histidine; Naproxen; MethotrexateDCC, Dicyclohexylcarbodiimide; HOBt, Hydroxybenzotriazole; TFA, Trifluoroacetic acid; DCM, Dichloromethane; DIPEA, N,N-Diisopropylethylamine; HBTU, o-Benzotriazol-1-yl-t

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Polyamide Amino Acids trimers as TAR RNA ligands and anti-HIV agents

Keywords: DIPEA، N، N-Diisopropylethylamine; Polyamide Amino Acids; TAR RNA ligands; Anti-HIV agentsNMP, N-methyl-2-pyrrolidinone; DIPEA, N,N-diisopropylethylamine; HBTU, 2-(1-H-benzotriazol-1-yl)1,1,3,3-tetramethyluroniumhexafluorophosphate; Pyr, pyridine; TFA, trifluoroacetic acid; TFMSA, trifluor

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases

Keywords: DIPEA، N، N-Diisopropylethylamine; ABz, ortho-aminobenzoate; AOMK, (acyloxy)methyl ketone; DCC, N,N′-dicyclohexylcarbodiimide; DIPEA, N,N-diisopropylethylamine; HEPES, 4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid; HOBt, 1-hydroxybenzotriazole; HBTU, O-(benzotriazol-1-yl)-N,N,N′,N′-te

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Fluorous silica gel-supported perfluoro-tagged palladium nanoparticles catalyze Suzuki cross-coupling reaction in water

Keywords: DIPEA، N، N-Diisopropylethylamine; FSG, fluorous silica gel; ICP, inductively coupled plasma; TEM, transmission electron microscope; TBAB, tetra-n-butylammonium bromide; DIPEA, N,N-diisopropylethylamine; EtOAc, ethyl acetate; DMF, dimethyl formamide; SDS, sodium dodecylsulphateFluorous sil

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Synthesis and characterization of de novo designed peptides modelling the binding sites of [4Fe–4S] clusters in photosystem I

Keywords: DIPEA، N، N-Diisopropylethylamine; Chl a, Chlorophyll a; CW, Continuous Wave; DCPIP, 2,6-dichlorophenolindophenol; DIPEA, N,N-diisopropylethylamine; β-DM, n-dodecyl-β-d-maltoside; ENDOR, Electron Nuclear DOuble Resonance; EPR, Electron Paramagnetic Resonance; ESEEM, Electron Spin Echo Enve

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2009 سفارش ترجمه

Secondary and tertiary structures of the transmembrane domains of the translocator protein TSPO determined by NMR. Stabilization of the TSPO tertiary fold upon ligand binding

Keywords: DIPEA، N، N-Diisopropylethylamine; DPC, dodecyl phosphocholine; DIPEA, N,N-diisopropylethylamine; DSS, dimethylsilapentane-sulfonic acid, sodium salt; HATU, 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo-[4,5-b]pyridinium hexafluorophosphate; HSQC, heteronuclear single quantum correlati

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Design, synthesis, and application of novel triclosan prodrugs as potential antimalarial and antibacterial agents

Keywords: DIPEA، N، N-Diisopropylethylamine; DIPEA, N,N-diisopropylethylamine; DMAE, dimethylaminoethanol; CDI, 1,1′-carbonyldiimidazole; MDMAEG, mono-(dimethylaminoethanyl)glutaryl; P. falciparum, Plasmodium falciparum; E. coli, Escherichia ColiProdrug; Triclosan; Antimalarial; Antibacterial; Plasm

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors

Keywords: DIPEA، N، N-Diisopropylethylamine; DIPEA, N,N-diisopropylethylamine; HATU, O-(7-azabenzotriazole-1-yl)-N,N,N′N′-tetramethyluronium hexafluorophosphate; pyr, pyridine; o-CAPN1, ovine calpain 1; o-CAPN2, ovine calpain 2; h-CAPN1, human calpain 1; h-CAPN2, human calpain 2; p-CAPN1, porcine ca

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Further structure–activity studies of lactam derivatives of MT-II and SHU-9119: Their activity and selectivity at human melanocortin receptors 3, 4, and 5

Keywords: DIPEA، N، N-Diisopropylethylamine; AAA, amino acid analysis; Boc, tert-butyloxycarbonyl; BSA, bovine serum albumin; Bzl, benzyl; tBu, tert-butyl; cAMP, adenosine 3′,5′-cyclic monophosphate; DCM, dichloromethane; DIPEA, N,N-diisopropylethylamine; DMF, N,N-dimethylformamide; Et3SiH, triethyl

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Elevated F2-isoprostanes in thalassemic patients

Keywords: DIPEA، N، N-Diisopropylethylamine; BHT, butylated hydroxytoluene; BSTFA, N,O-bis(trimethylsilyl)trifluoroacetamide; DIPEA, N,N-diisopropylethylamine; DTNB, 5, 5′-dithiobis-2-nitrobenzoic acid; F2-IsoPs, F2-isoprostanes; GSH-Px, glutathione peroxidase; PFBBr, pentafluorobenzylbromide; SOD,

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition

Keywords: DIPEA، N، N-Diisopropylethylamine; Dendrimer; Oligonucleotide; hVEGF; Antisense therapyBoc, tert-Butyloxycarbonyl; Dde, N-(1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl); CH3CN, acetonitrile; DCC, dicyclohexyl carbodiimide; DCM, dichloromethane; DIPEA, N,N-diisopropylethylamine; DMF, N,N-

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis

Keywords: DIPEA، N، N-Diisopropylethylamine; ESI-MS, electrospray ionization mass spectrometry; RCM, ring-closing metathesis; SPPS, solid phase peptide synthesis; SPE, solid phase extraction; Boc, tert-butyloxycarbonyl; DCM, dichloromethane; DiPEA, N,N-diisopropylethylamine; DMF, N,N-dimethylformami

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه