دانلود مقالات ISI درباره عامل ضد ویروسی مستقیم عمل + ترجمه فارسی

بررسی کاهش بار غفلت هپاتیت ویروسی در آفریقا: استراتژی برای یک رویکرد جهانی

ReviewReducing the neglected burden of viral hepatitis in Africa: Strategies for a global approach

Keywords: عامل ضد ویروسی مستقیم عمل; AIDS; acquired immunodeficiency syndrome; ALT; alanine aminotransferase; ANRS; French Research Agency on HIV/AIDS and viral hepatitis; ART; antiretroviral treatment; AST; aspartate aminotransferase; DAA; direct-acting antiviral agent; GAVI; Global Allianc

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

عامل های ضد ویروسی مستقیم و راه استقلال اینترفرون

Direct-Acting Antiviral Agents and the Path to Interferon Independence

Keywords: عامل ضد ویروسی مستقیم عمل; DAA; NS3/4A Protease Inhibitor; Nucleoside/Nucleotide; Non-nucleoside; DAA; direct-acting antiviral agent; DCV; daclatasvir; HCV; hepatitis C virus; HTA; host-targeted antiviral agent; IFN; interferon; ISG; interferon-stimulated gene; NI; nucleoside inhib

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Efficacy of Sofosbuvir and Velpatasvir, With and Without Ribavirin, in Patients With Hepatitis C Virus Genotype 3 Infection and Cirrhosis

Keywords: عامل ضد ویروسی مستقیم عمل; Direct-Acting Antiviral Agent; Outcome; Drug Resistance; AE; adverse event; HCV; hepatitis C virus; HIV; human immunodeficiency virus; NS5A; nonstructural protein 5A; NS5B; nonstructural protein 5B; RAS; resistance-associated substitution; SAE; serious ad

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase

Keywords: عامل ضد ویروسی مستقیم عمل; HCV NS5B; Polymerase; Cyclopropyl-fused indolobenzazepine; Metabolic stability; Direct-acting antiviral agent; Antiviral agent;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Efficacy of 8 Weeks of Sofosbuvir, Velpatasvir, and Voxilaprevir in Patients With Chronic HCV Infection: 2 Phase 3 Randomized Trials

Keywords: عامل ضد ویروسی مستقیم عمل; Direct-Acting Antiviral Agent; Shortened Duration Therapy; Clinical Trial; Comparison; CI; confidence interval; DAA; direct-acting antiviral agent; HCV; hepatitis C virus; SVR; sustained virologic response;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Changes in the Prevalence of Hepatitis C Virus Infection, Nonalcoholic Steatohepatitis, and Alcoholic Liver Disease Among Patients With Cirrhosis or Liver Failure on the Waitlist for Liver Transplantation

Keywords: عامل ضد ویروسی مستقیم عمل; Population Analysis; US; DAA Therapy; Obesity; ALD; alcohol-related liver disease; CI; confidence interval; CTP; Child-Turcotte-Pugh; CLF; chronic liver failure; DAA; direct-acting antiviral agent; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; HI

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Hepatitis due to Reactivation of Hepatitis B Virus in Endemic Areas Among Patients With Hepatitis C Treated With Direct-acting Antiviral Agents

Keywords: عامل ضد ویروسی مستقیم عمل; Therapy; Risk Factor; Coinfection; Prognostic Factor; CHC; chronic hepatitis C; DAA; direct-acting antiviral agent; HBeAg; hepatitis B e antigen; HBsAg; hepatitis B surface antigen; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HCV; hepatitis C v

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Real-World Effectiveness and Safety of Oral Combination Antiviral Therapy for Hepatitis C Virus Genotype 4 Infection

Keywords: عامل ضد ویروسی مستقیم عمل; Routine Clinical Practice; Direct-Acting Antiviral Agents; Cirrhosis; Genotype 4; DAA; direct-acting antiviral agent; EOT; end of treatment; GT; genotype; HCV; hepatitis C virus; LDV; ledipasvir; OMV; ombitasvir; PTV; paritaprevir; r; ritonavir; RBV; riba

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Effect of interferon-based and -free therapy on early occurrence and recurrence of hepatocellular carcinoma in chronic hepatitis C

Keywords: عامل ضد ویروسی مستقیم عمل; Direct-acting antiviral agent; Hepatocarcinogenesis; Wisteria floribunda agglutinin positive Mac-2 binding protein; HCC occurrence; HCC recurrence;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Daclatasvir Prevents Hepatitis C Virus Infectivity by Blocking Transfer of the Viral Genome to Assembly Sites

Keywords: عامل ضد ویروسی مستقیم عمل; Chronic Hepatitis C; Direct-Acting Antiviral Agent; DAA; CHX; cycloheximide; DCV; daclatasvir; DI; domain I; DMV; double membrane vesicle; ER; endoplasmic reticulum; HCV; hepatitis C virus; LD; lipid droplet; MOI; multiplicity of infection; NS; non-struct

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewThe importance of resistance to direct antiviral drugs in HCV infection in clinical practice

Keywords: عامل ضد ویروسی مستقیم عمل; HCV; hepatitis C virus; DAA; direct-acting antiviral agent; NS3; non-structural protein 3; NS5A; non-structural protein 5A; NS5B; non-structural protein 5B; RAVs; resistance associated variants; IP-10; interferon-gamma-inducible protein 10; IFNL4; interfe

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2016 سفارش ترجمه

Efficacy of the Combination of Sofosbuvir, Velpatasvir, and the NS3/4A Protease Inhibitor GS-9857 in Treatment-Naïve or Previously Treated Patients With Hepatitis C Virus Genotype 1 or 3 Infections

Keywords: عامل ضد ویروسی مستقیم عمل; Clinical Trial; LEPTON; Difficult to Treat; Time of Treatment; DAA; direct-acting antiviral agent; HCV; hepatitis C virus; PEG+RBV; pegylated interferon plus ribavirin; RAS; resistance-associated substitution; SOF; sofosbuvir; SVR12; sustained virologic r

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2016 سفارش ترجمه

Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients With Hepatitis C Virus Genotype 2, 3, 4, or 6 Infections in an Open-Label, Phase 2 Trial

Keywords: عامل ضد ویروسی مستقیم عمل; Clinical Trial; Direct-Acting Antiviral; DAA; Non-Genotype 1 HCV; CI; confidence interval; DAA; direct-acting antiviral agent; HCV; hepatitis C virus; RAS; resistance-associated substitution; SVR; sustained virologic response; SVR12; sustained virologic r

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2016 سفارش ترجمه

Case ReportRapid clearance of HCV-related splenic marginal zone lymphoma under an interferon-free, NS3/NS4A inhibitor-based treatment. A case report

Keywords: عامل ضد ویروسی مستقیم عمل; HCV; hepatitis C virus; NHL; non-Hodgkin lymphoma; SMZL; splenic marginal zone lymphoma; NS3; non-structural protein 3; IFN; interferon; RBV; ribavirin; FDV; faldaprevir; DLV; deleobuvir; DAA; direct-acting antiviral agent; MALT; mucosa-associated lymphoi

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Serious Pulmonary Toxicity Secondary to Novel Hepatitis C Antiviral Therapy in a Liver Transplant Recipient

Keywords: عامل ضد ویروسی مستقیم عمل; DAA; direct-acting antiviral agent; DAD; diffuse alveolar damage; FDA; Food and Drug Administration; HCV; hepatitis C virus; LT; liver transplant; SIM; simeprevir; SOF; sofosbuvir;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticleHepatitis C virus variants resistant to macrocyclic NS3-4A inhibitors subvert IFN-β induction by efficient MAVS cleavage

Keywords: عامل ضد ویروسی مستقیم عمل; CHC; chronic hepatitis C; DAA; direct-acting antiviral agent; HCV; hepatitis C virus; IFN; interferon; IP-10; interferon-γ-induced protein 10; MAVS; mitochondrial antiviral-signaling protein; MD; molecular dynamics; PI; protease inhibitor; RAV; resistanc

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticleVirology analyses of HCV isolates from genotype 1-infected patients treated with simeprevir plus peginterferon/ribavirin in Phase IIb/III studies

Keywords: عامل ضد ویروسی مستقیم عمل; HCV; hepatitis C virus; PR; peginterferon and ribavirin; QD; once-daily; GT; genotype; SVR; sustained virologic response; DAA; direct-acting antiviral agent; EC50; half maximal effective concentration; EOS; end of study; Hepatitis C virus; Genotype 1; Onc

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticlePharmacokinetics and safety of co-administered paritaprevir plus ritonavir, ombitasvir, and dasabuvir in hepatic impairment

Keywords: عامل ضد ویروسی مستقیم عمل; HCV; hepatitis C virus; Cmax; maximal plasma concentration; AUC; area under the plasma concentration-time curve; DAA; direct-acting antiviral agent; NS; nonstructural; CYP; cytochrome P450; Paritaprevir/r; paritaprevir administered with ritonavir; SVR12;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticleDrug-drug interaction profile of the all-oral anti-hepatitis C virus regimen of paritaprevir/ritonavir, ombitasvir, and dasabuvir

Keywords: عامل ضد ویروسی مستقیم عمل; PTV/r; paritaprevir/ritonavir; OBV; ombitasvir; DSV; dasabuvir; DAA; direct-acting antiviral agent; HCV; hepatitis C virus; Cmax; maximum observed plasma concentration; AUC; area under the plasma concentration-time curve; SVR; sustained virologic response

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Alisporivir Inhibition of Hepatocyte Cyclophilins Reduces HBV Replication and Hepatitis B Surface Antigen Production

Keywords: عامل ضد ویروسی مستقیم عمل; Cyclophilin Inhibition; Direct-Acting Antiviral Agent; Peptidyl-Prolyl Isomerase; Viral Replication; ALV; alisporivir; BL; baseline; CYP; cyclophilin; DMEM; Dulbecco's modified Eagle medium; DMSO; dimethyl sulfoxide; ELISA; enzyme-linked immunosorbent a

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2015 سفارش ترجمه

Journal of Hepatology Update: Hepatitis CSimplification of antiviral hepatitis C virus therapy to support expanded access in resource-limited settings

Keywords: عامل ضد ویروسی مستقیم عمل; ARV; antiretroviral; ART; antiretroviral therapy; DAA; direct-acting antiviral agent; FDC; fixed-dose combination; HCV; hepatitis C virus; HIV; human immunodeficiency virus; IFN; interferon; PCR; polymerase chain reaction; RBV; ribavirin; WHO; World Healt

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Original ResearchFull Report: Clinical-LiverABT-450, Ritonavir, Ombitasvir, and Dasabuvir Achieves 97% and 100% Sustained Virologic Response With or Without Ribavirin in Treatment-Experienced Patients With HCV Genotype 1b Infection

Keywords: عامل ضد ویروسی مستقیم عمل; PEARL-II; Ribavirin-Free; IFN; Interferon-Free Therapy; AE; adverse event; ALT; alanine aminotransferase; AST; aspartate aminotransferase; CI; confidence interval; DAA; direct-acting antiviral agent; HCV; hepatitis C virus; pegIFN; peginterferon; RBV; rib

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Research ArticleA randomized, double-blind, multiple-dose study of the pan-genotypic NS5A inhibitor samatasvir in patients infected with hepatitis C virus genotype 1, 2, 3 or 4

Keywords: عامل ضد ویروسی مستقیم عمل; HCV; hepatitis C virus; NS5A; nonstructural protein 5A; DAA; direct-acting antiviral agent; EC50; 50% effective concentration; CYP; cytochrome P450; HBV; hepatitis B virus; HIV; human immunodeficiency virus; QD; once daily; BID; twice daily; AE; adverse e

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Simeprevir With Peginterferon and Ribavirin Leads to High Rates of SVR in Patients With HCV Genotype 1 Who Relapsed After Previous Therapy: A Phase 3 Trial

Keywords: عامل ضد ویروسی مستقیم عمل; PROMISE; Chronic Hepatitis C; Drug; DAA; AE; adverse event; CI; confidence interval; DAA; direct-acting antiviral agent; EC50; median effective concentration; EOT; end of treatment; FDA; Food and Drug Administration; HCV; hepatitis C virus; IQR; interquar

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Combination of Vaniprevir With Peginterferon and Ribavirin Significantly Increases the Rate of SVR in Treatment-Experienced Patients With Chronic HCV Genotype 1 Infection and Cirrhosis

Keywords: عامل ضد ویروسی مستقیم عمل; Clinical Trial; Fibrosis; Direct-Acting Antiviral Agent; HCV; hepatitis C virus; LLQ; lower limit of quantification; mITT; modified intention-to-treat; P/R; peginterferon alfa and ribavirin; RAV; resistance-associated variants; RVR; rapid virologic respon

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Original ResearchFull Report: Basic and Translational-LiverA Serine Palmitoyltransferase Inhibitor Blocks Hepatitis C Virus Replication in Human Hepatocytes

Keywords: عامل ضد ویروسی مستقیم عمل; Direct-Acting Antiviral Agents; DAAs; HCV Lifecycle; Drug; cDNA; complementary DNA; DAA; direct-acting antiviral agent; HCV; hepatitis C virus; IC50; 50% inhibitory concentration; PCR; polymerase chain reaction; PEG-IFN; pegylated interferon alfa-2a; RBV;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Genetic Factors and Hepatitis C Virus Infection

Keywords: عامل ضد ویروسی مستقیم عمل; DAA; direct-acting antiviral agent; HCV; hepatitis C virus; ISG; interferon-stimulated genes; ITPase; inosine triphosphatase; pegIFN; peginterferon alfa; RBV; ribavirin; SNP; single nucleotide polymorphisms; SVR; sustained virological response;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

PharmacotherapyNew drug reviewBoceprevir: A Protease Inhibitor for the Treatment of Hepatitis C

Keywords: عامل ضد ویروسی مستقیم عمل; boceprevir; direct-acting antiviral agent; nonstructural protein 3 serine protease inhibitor; SCH 503034;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2012 سفارش ترجمه