Alendronate prevents angiotensin II-induced collagen I production through geranylgeranylation-dependent RhoA/Rho kinase activation in cardiac fibroblasts
Keywords: DMAPP، dimethylallyl pyrophosphate; Alendronate; Collagen I; Geranylgeranylation; RhoA; Rho kinaseALN, alendronate; Ang II, angiotensin II; ANOVA, a one-way analysis of variance; CF, cardiac fibroblast; DMAPP, dimethylallyl pyrophosphate; DMEM, Dulbecco's modified Eagle's medium; ECM, extra