Keywords: DMH، 1،2-dimethylhydrazine; Colon cancer; Nutraceuticals; Therapeutics; Marine organisms; Plant derivativesACC, acetyl CoA carboxylase; ACF, aberrant crypt foci; ACL, ATP-citrate lyase; ASTX, astaxanthin; COX-2, cyclooxygenase 2; DHA, decahexaenoic acid; DMH, 1,2-dimethylhydrazine;
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α-Mangostin from Garcinia mangostana Linn: An updated review of its pharmacological properties
Keywords: DMH، 1،2-dimethylhydrazine; CAT, catalase; CD, concentration required to double QR induction activity; CNS, central nervous system; COX, cyclooxygenase; CPK, creatine phosphokinase; LD50, lethal dose 50%; DMH, 1,2-dimethylhydrazine; GSH, reduced glutathione; GML, Garcinia mangostana
Thymoquinone effects on DMH-induced erythrocyte oxidative stress and haematological alterations during colon cancer promotion in rats
Keywords: DMH، 1،2-dimethylhydrazine; CAT, catalase; CD, conjugated diene; DMH, 1,2-dimethylhydrazine; GPx, glutathione peroxidase; Hb, haemoglobin; Ht, haematocrit; TBARS, thiobarbituric acid reactive substances; RBCs, red blood cells; Plts, platelets; ROS, reactive oxygen species; SOD, supe
Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis
Keywords: DMH، 1،2-dimethylhydrazine; AOM, azoxymethane; O6-meG, O6-methylguanine; MGMT, O6-methylguanine DNA methyltransferase; DMH, 1,2-dimethylhydrazine; CRC, colorectal cancer; DSB, double-strand breakAzoxymethane; O6-meG adduct; DNA repair; MGMT; Apoptosis; Colon cancer
Pathology of Rodent Models of Intestinal Cancer: Progress Report and Recommendations
Keywords: DMH، 1،2-dimethylhydrazine; Intestinal Neoplasms; Pathology; Genetically Engineered Mice; Disease Models; AnimalACF, aberrant crypt foci; AOM, azoxymethane; DMH, 1,2-dimethylhydrazine; DSS, dextran sodium sulfate; GI, gastrointestinal; GIN, gastrointestinal intraepithelial neoplasia
Is the tissue persistence of O6-methyl-2′-deoxyguanosine an indicator of tumour formation in the gastrointestinal tract?
Keywords: DMH، 1،2-dimethylhydrazine; 2-Cl-Ado, 2′-chloroadenosine; AOM, azoxymethane; CE, collision energy potential; CXP, collision exit potential; dGua, 2′-deoxyguanosine; DMH, 1,2-dimethylhydrazine; DP, declustering potential; EP, entrance potential; FP, focusing potential; IS, internal s
Xanthohumol, a prenylated flavonoid contained in beer, prevents the induction of preneoplastic lesions and DNA damage in liver and colon induced by the heterocyclic aromatic amine amino-3-methyl-imidazo[4,5-f]quinoline (IQ)
Keywords: DMH، 1،2-dimethylhydrazine; ACF, aberrant crypt foci; BSA, bovine serum albumin; CDNB, 1-chloro-2,4-dinitrobenzene; CYP, cytochrome P450; DMH, 1,2-dimethylhydrazine; DMSO, dimethyl sulfoxide; GI tract, gastro-intestinal tract; GSH, reduced glutathione; GSSG, oxidized glutathione; GS
Combination of curcumin and green tea catechins prevents dimethylhydrazine-induced colon carcinogenesis
Keywords: DMH، 1،2-dimethylhydrazine; ACF, aberrant crypt foci; DMH, 1,2-dimethylhydrazine; PCNA, proliferating cell nuclear antigen; EGCG, (−)-epigallocatechins-3-gallate; EGC, (−)-epigallocatechins; ECG, (−)-epicatechins-3-gallate; EC, (−)-epicatechins; C, (+)-catechinsCurcumin; Catechins;
Inhibitory effect of morin on DMH-induced biochemical changes and aberrant crypt foci formation in experimental colon carcinogenesis
Keywords: DMH، 1،2-dimethylhydrazine; DMH, 1,2-dimethylhydrazine; ACF, aberrant crypt foci; HMG CoA reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase; AOM, azoxymethane; MAM, methylazoxymethanol; O6-MeG, O6-methyl guanineColon cancer; DMH; ACF; Lipids; Glycoconjugates
Modifying effects of morin on the development of aberrant crypt foci and bacterial enzymes in experimental colon cancer
Keywords: DMH، 1،2-dimethylhydrazine; DMH, 1,2-dimethylhydrazine; ACF, Aberrant crypt foci; EDTA, Ethylene diamine tetra aceticacid; TCA, Trichloro aceticacidColon cancer; Bacterial enzymes; DMH; ACF
Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesi
Keywords: DMH، 1،2-dimethylhydrazine; MeIQx, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; DEN, diethylnitrosamine; GST-P, glutathione S-transferase placental form; DMH, 1,2-dimethylhydrazine; DMBA, 7,12-dimethylbenz[a]anthracene; DHPN, 2,2′-dihydroxy-di-n-propylnitrosamine; ACF, aberrant cr
Effects of resistant starch on colonic preneoplastic aberrant crypt foci in rats
Keywords: DMH، 1،2-dimethylhydrazine; AC, Aberrant crypt; ACF, Aberrant crypt foci; AOM, Azoxymethane; CRC, Colorectal cancer; DMH, 1,2-Dimethylhydrazine; HAS, High amylose maize starch; PI, Pre-initiation; P, Promotion; RPS, Raw potato starch; RS, Resistant starchResistant starch; Aberrant c
Possible carcinogenic risks of copper gluconate and their prevention by co-administered green tea catechins evaluated by a rat medium-term multi-organ carcinogenicity bioassay protocol
Keywords: DMH، 1،2-dimethylhydrazine; 8-oxoG, 8-oxoguanine; BBN, N-butyl-N-(4-hydroxybutyl)-nitrosamine; DEN, N-nitrosodiethylamine; DHPN, 2,2′-dihydroxy-di-n-propylnitrosamine; DMH, 1,2-dimethylhydrazine; GST-P, glutathione S-transferase placental form; LEC, Long Evans Cinnamon; MNU, N-methy
Mutagenic and carcinogenic potential of a textile azo dye processing plant effluent that impacts a drinking water source
Keywords: DMH، 1،2-dimethylhydrazine; AC, aberrant crypts; ACF, aberrant crypt foci; bw, body weight; DMH, 1,2-dimethylhydrazine; DWTP, drinking water treatment plant; TLC, thin layer chromatographyAberrant crypt foci; Azo dye; Colon carcinogenesis; Industrial effluent; Disperse dyes; Salmone
Effect of dietary caraway (Carum carvi L.) on aberrant crypt foci development, fecal steroids, and intestinal alkaline phosphatase activities in 1,2-dimethylhydrazine-induced colon carcinogenesis
Keywords: DMH، 1،2-dimethylhydrazine; ACF, aberrant crypt foci; ALP, alkaline phosphatase; b.w., body weight; CMC, carboxymethylcellulose; DMH, 1,2-dimethylhydrazine; H and E, hematoxylin and eosin; PBS, phosphate-buffered salineAberrant crypt foci; Bile acids; Caraway; Colon cancer; 1,2-Dime
Lack of chemopreventive effects of α-eleostearic acid on 7,12-dimethylbenz[a]anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary and colon carcinogenesis in female Sprague–Dawley rats
Keywords: DMH، 1،2-dimethylhydrazine; ACF, aberrant crypt foci; AOM, azoxymethane; CLA, conjugated linoleic acid; CLNA, conjugated α-linolenic acid; COX, cyclo-oxygenase; DHA, docosahexaenoic acid; DMBA, 7,12-dimethylbenz[a]anthracene; DMH, 1,2-dimethylhydrazine; EPA, eicosapentaenoic acid; H
Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in β-catenin that are independent of β-catenin mutation status
Keywords: DMH، 1،2-dimethylhydrazine; APC, adenomatous polyposis coli; AP-2α, activator protein-2α; CHL, chlorophyllin; DMH, 1,2-dimethylhydrazine; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GSK-3β, glycogen synthase kinase-3β; I3C, indole-3-carbinol; LEF, lymphoid enhancer factor; PCR-
Modulatory influence of dietary resveratrol during different phases of 1,2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant status and aberrant crypt foci development in rat colon carcinogenesis
Keywords: DMH، 1،2-dimethylhydrazine; ACF, Aberrant crypt foci; CAT, Catalase; DC, Diene conjugates; DMH, 1,2-dimethylhydrazine; GLUTs, Glucose transporter; GPX, Glutathione peroxidase; GR, Glutathione reductase; GSH, Reduced glutathione; GST, Glutathione S-transferase; LOOH, Lipid hydroperox