DNA-lesion mapping in mammalian cells
Keywords: DNA adducts; Mutation; PCR amplification; Primer extension
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Formation of adducts by bisphenol A, an endocrine disruptor, in DNA in vitro and in liver and mammary tissue of mice
Keywords: Endocrine disruptors; Bisphenol A; DNA adducts; Mouse liver; Mouse mammary cells
Accurate characterization of carcinogenic DNA adducts using MALDI tandem time-of-flight mass spectrometry
Keywords: DNA adducts; Collision-induced dissociation; MALDI; Tandem time-of-flight
Effect of vitamin levels on biomarkers of exposure and oxidative damage—The EXPAH study
Keywords: Molecular epidemiology; DNA adducts; Cross-sectional study
Brevetoxin B is a clastogen in rats, but lacks mutagenic potential in the SP-98/100 Ames test
Keywords: Brevetoxin; DNA adducts; Epoxidation; Harmful algal bloom; Karenia brevis; Metabolism
Screening of hydrophobic DNA adducts in flounder (Platichthys flesus) from the Baltic Sea
Keywords: DNA adducts; Biomarker; Fish; Platichthys flesus; PAH; Ecotoxicology
ECETOC workshop on the biological significance of DNA adducts: Summary of follow-up from an Expert Panel Meeting
Keywords: DNA adducts; Mutagenesis; Thresholds; Genotoxicity; Carcinogenicity; Dose–response; Mode of action; Risk assessment; Workshop
Differences between human slow N-acetyltransferase 2 alleles in levels of 4-aminobiphenyl-induced DNA adducts and mutations
Keywords: N-Acetyltransferase 2; Acetylator genotype; 4-Aminobiphenyl; DNA adducts
Time course evaluation of N-nitrosodialkylamines-induced DNA alkylation and oxidation in liver of mosquito fish
Keywords: N-Nitrosamines; Oxidatively damaged DNA; DNA alkylation; LC–MS/MS; Small fish model; Gambusia; Mosquitofish; DNA adducts
H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides
Keywords: PAH; Diol epoxide; BPDE; DBPDE; DNA adducts; H2AX
Molecular cloning of apoptosis-inducing Pierisin-like proteins, from two species of white butterfly, Pieris melete and Aporia crataegi
Keywords: Gb3, globotriaosylceramide; Gb4, globotetraosylceramideDNA ADP-ribosylation; Cytotoxicity; Apoptosis; Pierisin-3; Pierisin-4; DNA adducts; Oligo-capping method; TUNEL assay
Ultra-performance liquid chromatography-tandem mass spectrometry for rapid and highly sensitive analysis of stereoisomers of benzo[a]pyrene diol epoxide-DNA adducts
Keywords: UPLC; ESI-MS/MS; Benzo[a]pyrene; DNA adducts;
Increased micronuclei and bulky DNA adducts in cord blood after maternal exposures to traffic-related air pollution
Keywords: DNA adducts; Fetus; Micronuclei; Susceptibility; Traffic-related air pollution
Relative contribution of DNA strand breaks and DNA adducts to the genotoxicity of benzo[a]pyrene as a pure compound and in complex mixtures
Keywords: Polycyclic aromatic hydrocarbons; DNA damage; DNA adducts; Comet assay; Benzo[a]pyrene; HPLC-mass spectrometry; Oxidative stress;
Mutagenicity, stable DNA adducts, and abasic sites induced in Salmonella by phenanthro[3,4-b]- and phenanthro[4,3-b]thiophenes, sulfur analogs of benzo[c]phenanthrene
Keywords: Mutagenicity; Salmonella; Sulfur-PAH; DNA adducts
Differences in DNA damage and repair produced by systemic, hepatocarcinogenic and sarcomagenic dibenzocarbazole derivatives in a model of rat liver progenitor cells
Keywords: AFB1; aflatoxin B1; B[a]P; benzo[a]pyrene; DBC; 7H-dibenzo[c,g]carbazole; DiMeDBC; 5,9-dimethyldibenzo[c,g]carbazole; Fpg; formamidopyrimidine-DNA glycosylase/AP endonuclease; γH2AX; histone H2AX phosphorylated on Ser139; MI; mitotic index; MNi; micronuc
Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells
Keywords: Breast cancer; MCF-7 cells; Long-term estrogen exposure; Benzo(a)pyrene; DNA adducts
Ethyl methanesulfonate toxicity in Viracept—A comprehensive human risk assessment based on threshold data for genotoxicity
Keywords: Viracept; Ethyl methanesulfonate; Contamination; Mutation threshold; Cancer; Birth defects; Patient exposure risk; Cmax; AUC; Ethyl valine adducts; DNA adducts; DNA repair; MGMT
DNA damage associated with PCBs in the whole blood cells of Inuit
Keywords: PCBs; Inuit; DNA adducts; 32P-postlabeling
Exposure of mice to cigarette smoke and/or light causes DNA alterations in heart and aorta
Keywords: Environmental cigarette smoke; UV-containing light; Oxidatively damaged DNA; DNA adducts; Heart; Aorta
No-observed effect levels are associated with up-regulation of MGMT following MMS exposure
Keywords: O6-methylguanine DNA methyltransferase; N-methylpurine-DNA glycoslase; Thresholds; Methyl methanesulphonate; DNA adducts; DNA repair;
Dose-dependent reduction of 3,2′-dimethyl-4-aminobiphenyl-derived DNA adducts in colon and liver of rats administered celecoxib
Keywords: 3,2′-Dimethyl-4-aminobiphenyl; DNA adducts; Celecoxib; Colon cancer; 32P-postlabeling
Transplacental transfer of acrylamide and glycidamide are comparable to that of antipyrine in perfused human placenta
Keywords: AA, acrylamide; GA, glycidamide; LC/MS, liquid chromatography/mass spectrometryFetal exposure; DNA adducts; Xenobiotic metabolism; Food carcinogens
Lipid peroxidation-related 1,N2-propanodeoxyguanosine-DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil
Keywords: DNA adducts; Lipid peroxidation; Fatty acids; Cancer
Quantification of aristolochic acid-derived DNA adducts in rat kidney and liver by using liquid chromatography–electrospray ionization mass spectrometry
Keywords: Aristolochic acid; Aristolochic acid nephropathy; DNA adducts; LC–MS
Possible genotoxic modes of action for naphthalene
Keywords: Naphthalene; Cancer; Carcinogenicity; Mutagenicity; Mode of action; Mechanism of action; Genotoxicity; Metabolism; 1,2-Naphthoquinone; DNA adducts; Stable adducts; Depurinating adducts; Biomarkers
DNA adducts and PM10 exposure in traffic-exposed workers and urban residents from the EPIC-Florence City study
Keywords: DNA adducts; Environmental epidemiology; Particulate matter; Smoking; Occupational exposure
Tumor necrosis factor-α potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression
Keywords: TNF-α; BaP; CYP1B1; Liver progenitor cells; AhR; DNA adducts;
Genotoxic effects of acrylamide and glycidamide in mouse lymphoma cells
Keywords: Acrylamide; Glycidamide; Genotoxicity; Loss of heterozygosity; DNA adducts
Mutagenicity and DNA adduct formation of PAH, nitro-PAH, and oxy-PAH fractions of atmospheric particulate matter from São Paulo, Brazil
Keywords: Air mutagenicity; Nitroarenes; Air pollution; DNA adducts; Nitroaromatics; Salmonella microsome assay; Ames test; YG1041; TA98
Preparation, identification and analysis of stereoisomeric anti-benzo[a]pyrene diol epoxide–deoxyguanosine adducts using phenyl liquid chromatography with diode array, fluorescence and tandem mass spectrometry detection
Keywords: Benzo[a]pyrene; DNA adducts; (±)-anti-BPDE; HPLC; LC–MS/MS
Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide
Keywords: Benzo[a]pyrene; Dibenzo[a,l]pyrene; Nucleotide excision repair; DNA adducts; Replication bypass; Mutations
DNA adducts formation and induction of apoptosis in rat liver epithelial ‘stem-like’ cells exposed to carcinogenic polycyclic aromatic hydrocarbons
Keywords: PAHs; Liver progenitor cells; Cytochromes P450; DNA adducts; p53 protein; Apoptosis
DNA repair in response to anthracycline–DNA adducts: A role for both homologous recombination and nucleotide excision repair
Keywords: DNA repair; Doxorubicin; DNA adducts; Barminomycin; Doxoform
Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy
Keywords: Aristolochic acid; Aristolochic acid nephropathy; Balkan endemic nephropathy; Reductive activation; DNA adducts
The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo
Keywords: DNA adducts; Carcinogenesis; Diesel exhaust; PAH; Cytochrome P450
Modifications of nucleosides by endogenous mutagens–DNA adducts arising from cellular processes
Keywords: Reactive oxygen species; Endogenous mutagens; Oxidized bases; DNA adducts; Lipid peroxidation; DNA damage
Biomarkers of exposure to carcinogenic PAHs and their relationship with environmental factors
Keywords: PAH; polycyclic aromatic hydrocarbon; c-PAHs; carcinogenic PAHs; B[a]P; benzo[a]pyrene; B[a]P DNA adduct; a 'benzo[a]pyrene-like' adduct that chromatographed on 2D TLC at the same position as authentic B[a]P adduct; Benzo[a]pyrene; Carcinogenic polycy
Inhibition by dietary hydroquinone of acetylaminofluorene induction of initiation of rat liver carcinogenesis
Keywords: Hydroquinone; Antioxidants; Hepatocarcinogenesis; DNA adducts; Cell proliferation; Hepatocellular altered foci
3-Methylcholanthrene elicits DNA adduct formation in the CYP1A1 promoter region and attenuates reporter gene expression in rat H4IIE cells
Keywords: 3-Methylcholanthrene; CYP1A1; Gene regulation; 32P-Postlabeling; Ah receptor; DNA adducts; Sequence-specific; Transient transfections;
Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells
Keywords: DNA adducts; Hair dyes; 4-Aminobiphenyl; PhIP; Breast; Aromatic amines; Tobacco;
Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and α-hydroxytamoxifen
Keywords: CYP, cytochrome P450; ES-MS, electrospray mass spectrometry; ES-MS/MS, electrospray tandem mass spectrometry; HPLC, high performance liquid chromatographyN,N-Didesmethyltamoxifen; Tamoxifen; DNA adducts
Usefulness of biomarkers in population studies: From exposure to susceptibility and to prediction of cancer
Keywords: Biomarkers; Population studies; Susceptibility; DNA adducts; Chromosome aberrations; Gene mutations; Challenge assay; Mutagen sensitivity assay; Cancer risk assessment
Simultaneous analysis of four stereoisomers of anti-benzo[a]pyrene diol epoxide-deoxyguanosine adducts in short oligodeoxynucleotides using reversed-phase high-performance liquid chromatography
Keywords: Benzo[a]pyrene; (±)-anti-BPDE; DNA adducts;
Characterization of naphtho[1,2-a]pyrene and naphtho[1,2-e]pyrene DNA adducts in C3H10T1/2 fibroblasts
Keywords: DNA adducts; Naphthopyrene; 32P-postlabeling; C3H10T1/2 fibroblastsPAHs, polycyclic aromatic hydrocarbons; DB[a,l]P, dibenzo[a,l]pyrene; C3H10T1/2, C3H10T1/2C18; B[a]P, benzo[a]pyrene; N[1,2-a]P-9,10-diol, (±)-trans-9,10-dihydroxy-9,10-dihydro-N[1,2-a]P;
The metabolism and molecular toxicology of chloroprene
Keywords: Chloroprene; Metabolism; DNA adducts;
Comparison of the nucleic acid covalent binding capacity of two nitro-substituted benzazolo[3,2-a]quinolinium salts upon enzymatic reduction
Keywords: DNA adducts; Bioreductive drugs; Benzazolo[3,2-a]quinolinium; Hypoxia; Mass spectrometry; BQ; benzazolo[3,2-a]quinolinium chloride; NBQ or BQ-NO2; nitrobenzazolo[3,2-a]quinolinium chloride; ABQ or BQ-NH2; aminobenzazolo[3,2-a]quinolinium chloride; NBQ-38;
Mutagenic bypass of the butadiene-derived 2′-deoxyuridine adducts by polymerases η and ζ
Keywords: BD, 1,3-butadiene; EB, 1,2-epoxy-3-butene; DEB, 1,2,3,4-diepoxybutane; HMVK, hydroxymethylvinylketone; EBD, 3,4-epoxy-1,2-butanediol; BD N3-dU, N3 2′ deoxyuridine; pol, polymerase; dC, deoxycytosineButadiene; DNA adducts; Butadiene-derived 2′-deoxyuridine
Effects of diet on biomarkers of exposure and effects, and on oxidative damage
Keywords: PAHs; polycyclic aromatic hydrocarbons; 8-OxodG; 8-oxo-7,8-dihydro-2â²-deoxyguanosine; c-PAH; carcinogenic PAH; M1dG; cyclic pyrimidopurinone Nâ1,N2 malondialdehyde-2â²-deoxyguanosine; PCA; principal component analysis; GLM; general linear model; FISH
Follow-up testing of rodent carcinogens not positive in the standard genotoxicity testing battery: IWGT workgroup report
Keywords: IWGT; Genetic toxicology testing; Organ-specificity; Mode of action; Carcinogenicity testing; Transgenic mutation assay; Comet assay; DNA adducts