دانلود مقالات ISI درباره داکت + ترجمه فارسی

Synthesis, anti-inflammatory, p38α MAP kinase inhibitory activities and molecular docking studies of quinoxaline derivatives containing triazole moiety

Keywords: داکت; Quinoxaline; p38α MAP kinase; Docking; Anti-inflammatory; Ulcerogenicity;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Synthesis of podophyllotoxin linked β-carboline congeners as potential anticancer agents and DNA topoisomerase II inhibitors

Keywords: داکت; β-Carbolines; Podophyllotoxin; Topoisomerase II inhibition; Cytotoxicity; Docking;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HT7 receptor agents with antidepressant activity

Keywords: داکت; Serotonin receptors; 5-HT7R ligands; Hydantoin; Arylpiperazine; Docking; Antidepressant; CNS drugability;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacophore-based drug design for potential AChE inhibitors from Traditional Chinese Medicine Database

Keywords: داکت; AD; AChE; Flavonoids; TCM; Pharmacophore models; Docking;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

[1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A3 adenosine receptor subtype

Keywords: داکت; G protein-coupled receptor; Adenosine receptor; A3 antagonist; [1,2,4]triazolo[1,5-c]pyrimidine; Molecular modeling; Docking; AR; adenosine receptor; cAMP; cyclic adenosine monophosphate; CCPA; 2-chloro-N6-cyclopentyladenosine; CHO; chinese hamster ovary;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

In silico and in vitro analysis of coumarin derivative induced anticancer effects by undergoing intrinsic pathway mediated apoptosis in human stomach cancer

Keywords: داکت; SBC; Apoptosis; Docking; ADME; Stomach cancer cell line (AGS); Anti-proliferative; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; ADME; absorption, distribution, metabolism and excretion; FBS; fetal bovine serum; RPMI; rosewell park m

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Integration of multi-scale molecular modeling approaches with experiments for the in silico guided design and discovery of novel hERG-Neutral antihypertensive oxazalone and imidazolone derivatives and analysis of their potential restrictive effects on cel

Keywords: داکت; AT1 receptor; Virtual screening; Docking; MD simulations; Synthesis; Wound healing; Cell cycle analysis; Binary QSAR models;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production

Keywords: داکت; Indole-2-carboxamides; Pyrazino[1,2-a]indole; EGFR; BRAF; Docking; Anti-cancer; Anti-oxidant;

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Molecular determinants of PPARγ partial agonism and related in silico/in vivo studies of natural saponins as potential type 2 diabetes modulators

Keywords: داکت; Type 2 diabetes; Saponins; PPARγ; Partial agonists; Pharmacophore; Docking; CAT; catalase; GSH; reduced glutathione; HB; hydrogen bond; MDA; malondialdehyde; NADPH; beta-nicotinamide adenine dinucleotide 2′-phosphate; PDB; Protein Data Bank; PPARγ;

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

Structure-based drug design for envelope protein E2 uncovers a new class of bovine viral diarrhea inhibitors that block virus entry

Keywords: داکت; BVDV; Pestivirus; Docking; Virtual screening; Reporter virus; Antivirals;

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

Molecular docking, vibrational, structural, electronic and optical studies of {4 - (2, 6) dichlorophenyl amino 2 - methylidene 4 - oxobutanoic acid and 4- (2, 5)} dichlorophenyl amino 2 - methylidene 4 - oxobutanoic acid - A comparative study

Keywords: داکت; Butanoic acid; Fukui; RDG; DSSC; TD-DFT; Docking;

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

Design, synthesis and biological assessment of new thiazolylhydrazine derivatives as selective and reversible hMAO-A inhibitors

Keywords: داکت; Thiazole; Hydrazine; hMAO enzymes; Enzyme inhibition; Docking;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

Modeling, dynamics and phosphoinositide binding of the pleckstrin homology domain of two novel PLCs: η1 and η2

Keywords: داکت; Pleckstrin homology domain; Phosphoinositide binding; Molecular modeling; Docking; MD simulation; PLC; Phospholipase C; PHη1; PH domain of PLCη1; PHη2; PH domain of PHη2; IP3; inositol-(1,4,5)-triphosphate; IP4; Inositol-(1,3,4,5)-tetrakisphosphate; u

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

Synthesis, spectroscopic analyses (FT-IR and NMR), vibrational study, chemical reactivity and molecular docking study and anti-tubercular activity of condensed oxadiazole and pyrazine derivatives

Keywords: داکت; DFT; Oxadiazole; ALIE; RDF; Docking;

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

Rutin attenuates negatively charged surfactant (SDS)-induced lysozyme aggregation/amyloid formation and its cytotoxicity

Keywords: داکت; Amyloid; Lysozyme; SDS; Rutin; Cytotoxcity; Genotoxcity; Docking;

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2018 سفارش ترجمه

The 3-phenylcoumarin derivative 6,7-dihydroxy-3-[3′,4′-methylenedioxyphenyl]-coumarin downmodulates the FcγR- and CR-mediated oxidative metabolism and elastase release in human neutrophils: Possible mechanisms underlying inhibition of the formation a

Keywords: داکت; ABAH; 4-aminobenzoic acid hydrazide; ANOVA; analysis of variance; CL-luc; lucigenin-enhanced chemiluminescence; CL-lum; luminol-enhanced chemiluminescence; CR; complement receptor; DAPI; 4',6-diamidino-2-phenylindole dihydrochloride; DMSO; dimethyl sulfox

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2018 سفارش ترجمه

Synthesis, docking, QSAR, ADMET and antimicrobial evaluation of new quinoline-3-carbonitrile derivatives as potential DNA-gyrase inhibitors

Keywords: داکت; ADMET; DNA-gyrase; Antimicrobial activity; Docking; QSAR; Quinoline-3-carbonitrile;

دانلود رایگان متن کامل مقاله ISI 63 صفحه سال انتشار : 2018 سفارش ترجمه

Discovery of a cobalt complex with high MEK1 binding affinity

Keywords: داکت; MEK; Kinase; Schiff base; Cobalt complex; Docking;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Linolenic acid prevents early and advanced glycation end-products (AGEs) modification of albumin

Keywords: داکت; Linolenic acid; Advanced glycation end-products; HbA1c; Docking; Confocal microscopy;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Docking based design of diastereoisomeric MTCA as GPIIb/IIIa receptor inhibitor

Keywords: داکت; GPIIb/IIIa; Platelet activation; Thrombosis; Inhibitor; Docking;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

New Caspase-1 inhibitor by scaffold hopping into bio-inspired 3D-fragment space

Keywords: داکت; Scaffold hopping; 3D fragments; Docking; Natural product; Caspase-1;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases

Keywords: داکت; Carbonic anhydrase; Isatin; 2-Indolinone; Docking;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Supervised machine learning techniques to predict binding affinity. A study for cyclin-dependent kinase 2

Keywords: داکت; Bioinformatics; CDK2; Kinase; Drug design; Docking; Machine learning;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Interaction of an antiepileptic drug, lamotrigine with human serum albumin (HSA): Application of spectroscopic techniques and molecular modeling methods

Keywords: داکت; Lamotrigine; HSA; Interaction; Docking; Spectroscopy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of novel inhibitors of multidrug-resistant Acinetobacter baumannii

Keywords: داکت; AB_OmpW2; A. baumannii OmpW; MIC; minimum inhibitory concentration; MDR; multidrug-resistant; CFU; colony-forming units; Acinetobacter baumannii; In silico; Docking; Antibacterial; Outer membrane protein;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Quinazolinone derivatives: Synthesis and comparison of inhibitory mechanisms on α-glucosidase

Keywords: داکت; Quinazolinone; α-Glucosidase; Fluorescence; Docking;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Structure-based drug design of novel peptidomimetic cellulose derivatives as HCV-NS3 protease inhibitors

Keywords: داکت; Cellulose; Docking; HCV; Hexa-peptide; NS3 protease; NS3 inhibitors; Structure-based drug design;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Two new substituted polychiral 5, 6-dihydro-α-pyrones from Orthosiphon diffusus and molecular docking studies

Keywords: داکت; TOPO-I-DNA complex; Topoisomerase-I - DNA complex; LRESIMS; low resolution electrospray ionization mass spectrometry; NMR; nuclear magnetic resonance; COSY; 1H-1H correlation spectroscopy; HSQC; heteronuclear single-quantum correlation; NOESY; nuclear ove

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain

Keywords: داکت; Alpha; amplified luminescent proximity homogeneous assay; ATAD2; ATAD2 ATPase family, AAA domain containing 2; BAZ2A; bromodomain adjacent to zinc finger domain protein 2A; BAZ2B; bromodomain adjacent to zinc finger domain protein 2B; BRPF1; bromodomain a

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery and mechanism of action of Novel Baicalein modified derivatives as potent antihepatitis agent

Keywords: داکت; Anti-hepatitis B virus; Baicalein; HepG2.2.15 cells; Pharmacokinetic; HBV transgenic mice; Docking;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Structure-activity relationships and docking studies of synthetic 2-arylindole derivatives determined with aromatase and quinone reductase 1

Keywords: داکت; 2-Arylindole; Anticancer; Aromatase; Docking; Estrogen; Quinone reductase 1;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular modelling and docking analysis of katG and rpoB gene in MDR-TB isolates from North Central Indian population

Keywords: داکت; Sahariya tribe; MDR-TB; Molecular modelling; Docking;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Quercetin, ascorbic acid, caffeine and ellagic acid are more efficient than rosiglitazone, metformin and glimepiride in interfering with pathways leading to the development of neurological complications associated with diabetes: A comparative in-vitro stu

Keywords: داکت; Diabetes mellitus; Neuropathy; Docking; Natural molecules; Glucose uptake;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery and structure-activity relationship of auriculatone: A potent hepatoprotective agent against acetaminophen-induced liver injury

Keywords: داکت; Auriculatone; Acetaminophen-induced liver injury; Hepatoprotective agent; Structure activity relationship; Docking;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Purification, modification and inhibition mechanism of angiotensin I-converting enzyme inhibitory peptide from silkworm pupa (Bombyx mori) protein hydrolysate

Keywords: داکت; Silkworm pupa protein; Angiotensin I-converting enzyme; Inhibitory peptide; Stability; Docking;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

The computer-aided discovery of novel family of the 5-HT6 serotonin receptor ligands among derivatives of 4-benzyl-1,3,5-triazine

Keywords: داکت; Serotonin receptors; 5-HT6 ligands; 1,3,5-Triazine; Docking; CNS drugability;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Biobetters From an Integrated Computational/Experimental Approach

Keywords: داکت; Rational drug design; Molecular dynamics; Docking; Potential of mean force; Free energy perturbation;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Evidence of bovine serum albumin-viologen herbicide binding interaction and associated structural modifications

Keywords: داکت; BSA; EV; Interaction; Spectroscopy; Docking;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Studies on molecular interactions between Schiff bases and eye lens chaperone human αA-crystallin

Keywords: داکت; Human αA-crystallin; Schiff base; Fluorescence quenching; Resonance energy transfer; CD; Docking;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Structure-based identification of inhibitors targeting obstruction of the HIVgp41 N-heptad repeat trimer

Keywords: داکت; HIV; gp41; Docking; DOCK; Virtual screening; Footprint similarity; Hungarian similarity; Viral entry; Structure-based drug design; Computer-aided drug design;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and biological activity of 3-oxoamino-benzenesulfonamides as selective and reversible LSD1 inhibitors

Keywords: داکت; LSD1; Inhibitors; Selective; Reversible; Docking; DCM; dichloromethane; TBSCl; tert-butyldimethylsilyl chloride; TBAF; tetrabutylammonium fluoride; rt; room temperature; DMF; N,N-dimethylformamide; THF; tetrahydrofuran; DIEA; N,N-diisopropylethylamine;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Probing the inhibitory activity of epigallocatechin-gallate on toxic aggregates of mutant (L84F) SOD1 protein through geometry based sampling and steered molecular dynamics

Keywords: داکت; EGCG; SOD1; L84F; Docking; Conformational sampling;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Conf-VLKA: A structure-based revisitation of the Virtual Lock-and-key Approach

Keywords: داکت; Vlka; Descriptors; Docking; Target fishing; Ligand-based; Structure-based; Biological target; Inhibitors;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Brief CommunicationQSAR, docking studies of 1,3-thiazinan-3-yl isonicotinamide derivatives for antitubercular activity

Keywords: داکت; QSAR; Docking; Thiazinan-3-yl isonicotinamide; Enoyl ACP reductase;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Computational insights into the molecular interactions of environmental xenoestrogens 4-tert-octylphenol, 4-nonylphenol, bisphenol A (BPA), and BPA metabolite, 4-methyl-2, 4-bis (4-hydroxyphenyl) pent-1-ene (MBP) with human sex hormone-binding globulin

Keywords: داکت; Endocrine disruption; Octylphenol; Bisphenol A; Nonylphenol; Docking; Sex hormone-binding globulin;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Toward a hierarchical virtual screening and toxicity risk analysis for identifying novel CA XII inhibitors

Keywords: داکت; Carbonic anhydrase isoform XII; Pharmacophore modeling; Virtual screening; Toxicity; Docking; Tanimoto;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

In silico and in vitro inhibition of cytochrome P450 3A by synthetic stilbenoids

Keywords: داکت; CYP; cytochrome P450; P450s; cytochrome P450 enzymes; RLM; rat liver microsomes; CYP3A4; Resveratrol; Nitrostilbene; Di-methoxy-nitrostilbene; Microsomes; Docking;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Machine learning and docking models for Mycobacterium tuberculosis topoisomerase I

Keywords: داکت; Bayesian models; Collaborative drug discovery tuberculosis database; Docking; Function class fingerprints; Homology model; Mycobacterium tuberculosis; Topoisomerase; Tuberculosis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Mefloquine inhibits voltage dependent Nav1.4 channel by overlapping the local anaesthetic binding site

Keywords: داکت; Docking; Local anaesthetic; Mefloquine; Oocytes; Selectivity filter;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

The potential roles of Pinto bean (Phaseolus vulgaris cv. Pinto) bioactive peptides in regulating physiological functions: Protease activating, lipase inhibiting and bile acid binding activities

Keywords: داکت; Bioactive peptides; Docking; Phaseolus vulgaris cv. Pinto; Physiological effects;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه