
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3′-carboxamido)morphinan analogues as opioid receptor ligands
Keywords: cAMP, cyclic adenosine monophosphate; CHO, Chinese hamster ovary; DAMGO, [d-Ala2-MePhe4-Gly(ol)5]enkephalin; DFT, density functional theory; DOR, delta opioid receptor; DPN, diprenorphine; EDCI, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide; GIRK, G prote