دانلود مقالات ISI درباره تعاملات دارویی + ترجمه فارسی

Metabolic Pathway of Icotinib In Vitro: The Differential Roles of CYP3A4, CYP3A5, and CYP1A2 on Potential Pharmacokinetic Drug-Drug Interaction

Keywords: تعاملات دارویی; drug interaction; drug metabolizing enzyme; cancer chemotherapy; human liver microsomes; in vitro-in vivo correlations (IVIVC); mass spectrometry; CYP; cytochrome P450; HRMS; high-resolution mass spectrometer; LC; liquid chromatography; MS; mass spect

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2018 سفارش ترجمه

Effect of Fluconazole on the Pharmacokinetic Properties of Imrecoxib, a Novel NSAID: A Single-center, Open-label, Self-controlled Study in Healthy Chinese Male Volunteers

Keywords: تعاملات دارویی; COX-2 inhibitor; drug interaction; fluconazole; imrecoxib; pharmacokinetics; NASID;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Clinical trials on drug-drug interactions registered in ClinicalTrials.gov reported incongruent safety data in published articles: an observational study

Keywords: تعاملات دارویی; Clinical trials on drug-drug interaction as topic; Drug interaction; Databases; Reporting; Adverse events; Bias;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Mechanistic Physiologically Based Pharmacokinetic Modeling of the Dissolution and Food Effect of a Biopharmaceutics Classification System IV Compound-The Venetoclax Story

Keywords: تعاملات دارویی; amorphous; absorption, distribution, metabolism, and excretion (ADME); bioavailability; food effect; physiologically based pharmacokinetic modeling; clinical pharmacokinetics; intestinal absorption; passive diffusion/transport; drug interaction; ASD; Amor

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Drug interactions between non-rifamycin antibiotics and hormonal contraception: a systematic review

Keywords: تعاملات دارویی; antibiotics; contraceptive failure; drug interaction; hormonal contraception; pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Effect of genetic polymorphism on the inhibition of dopamine formation from p-tyramine catalyzed by brain cytochrome P450 2D6

Keywords: تعاملات دارویی; CYP2D6; Dopamine formation; Genetic polymorphism; Drug interaction; CLint; intrinsic clearance; CYP or P450; cytochrome P450; DHEA; dehydroepiandrosterone; IC50; 50% inhibitory concentration; Iu; unbound concentration of the inhibitor; Ki; inhibitory cons

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Interactions between tafenoquine and artemisinin-combination therapy partner drug in asexual and sexual stage Plasmodium falciparum

Keywords: تعاملات دارویی; Plasmodium falciparum; Tafenoquine; Malaria; Gametocyte; Drug interaction; 8-Aminoquinoline; Isobologram; ACT;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Correlation of binding efficacies of DNA to flavonoids and their induced cellular damage

Keywords: تعاملات دارویی; Drug interaction; Flavonoids; Cytotoxicity; Comet assay; Antioxidant;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Supplemental Analysis of the Prediction of Hepatic Clearance of Binary Mixtures of Bisphenol A and Naproxen Determined in an Isolated Perfused Rat Liver Model to Promote the Understanding of Potential Albumin-Facilitated Hepatic Uptake Mechanism

Keywords: تعاملات دارویی; albumin-mediated uptake; clearance; DDI; drug interaction; hepatocytes; IVIVE; IPRL; pharmacokinetics; PBPK models;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

A validated LC-MS/MS method for the estimation of glimepiride and pitavastatin in rat plasma: Application to drug interaction studies

Keywords: تعاملات دارویی; Glimepiride; Pitavastatin; LC-MS/MS; Drug interaction; Rat liver microsomes;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleImpact of azithromycin on the clinical and antimicrobial effectiveness of tobramycin in the treatment of cystic fibrosis

Keywords: تعاملات دارویی; Inhaled antibiotics; Drug interaction; Pseudomonas aeruginosa; Clinical trial; Azithromycin; Tobramycin; MexXY; Cystic fibrosis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

In vitro inhibitory mechanisms and molecular docking of 1′-S-1′-acetoxychavicol acetate on human cytochrome P450 enzymes

Keywords: تعاملات دارویی; 1′-S-1′-acetoxychavicol acetate; Drug interaction; Cytochrome P450; Inhibition; Enzyme kinetics; Molecular docking; ACA; 1′-s-1′-acetoxychavicol acetate; BOMCC; 7-benzyloxymethyloxy-3-cyanocoumarin; CYPS; cytochrome p450s; DBOMF; dibenzyloxymethyl

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Intestinal Drug Interactions Mediated by OATPs: A Systematic Review of Preclinical and Clinical Findings

Keywords: تعاملات دارویی; drug interaction; inhibition; transporter; organic anion-transporting polypeptide transporters; intestinal absorption; polymorphism; AUC; area under the plasma concentration-time curve; DDIs; drug-drug interactions; EMA; European Medicines Agency; FDA

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods

Keywords: تعاملات دارویی; drug interaction; cytochrome P450s; membrane transport/transporters; regulatory; guidance/guideline; ADME; absorption, distribution, metabolism and excretion; BCRP; breast cancer resistance protein; CYP; cytochrome P-450; d; induction calibration factor;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Prediction of Hepatic Efflux Transporter-Mediated Drug Interactions: When Is it Optimal to Measure Intracellular Unbound Fraction of Inhibitors?

Keywords: تعاملات دارویی; transporters; drug interaction; hepatocytes; pharmacokinetics/pharmacodynamics; protein binding; AFE; average fold error; AUC; area under the curve; BSA; bovine serum albumin; CLBile; biliary clearance; CLBL; basolateral efflux clearance; CLUptake; uptake

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions

Keywords: تعاملات دارویی; clinical pharmacokinetics; drug interaction; race; organic anion-transporting polypeptide transporters; ABC transporters; efflux pumps; hepatic transport; intestinal absorption;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Effects of Histamine 2-receptor Antagonists and Proton Pump Inhibitors on the Pharmacokinetics of Gefitinib in Patients With Non-small-cell Lung Cancer

Keywords: تعاملات دارویی; CYP2C19; Drug interaction; Gefitinib; Histamine 2-receptor antagonists; Proton pump inhibitors;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Propofol-fentanyl interaction in Beagles - Apnea, response to mechanical ventilation, endotracheal tube, and tetanic stimulation

Keywords: تعاملات دارویی; Dog; Drug interaction; Fentanyl; Pharmacodynamics; Propofol;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Simulations of Cytochrome P450 3A4-Mediated Drug-Drug Interactions by Simple Two-Compartment Model-Assisted Static Method

Keywords: تعاملات دارویی; bioavailability; cytochrome P450; drug interaction; dynamic simulation; first pass metabolism; hepatic clearance; intestinal metabolism; pharmacokinetics; simulations; parallel tube model; Ae (Ae,oral); dose fractions of urinary excreted unchanged drug af

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models

Keywords: تعاملات دارویی; cytochrome P450; drug interaction; hepatic clearance; mathematical model; organic anion-transporting polypeptide transporters; pharmacokinetics; AUC; area under the plasma concentration-time curve; CL; clearance; CLint,all; overall hepatic intrinsic cle

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2017 سفارش ترجمه

The association between antidepressant use and glycemic control in the Southern Community Cohort Study (SCCS)

Keywords: تعاملات دارویی; Diabetes; Antidepressants; A1C; Glycemic control; Drug interaction;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Evaluation of the in vitro and in vivo metabolic pathway and cytochrome P450 inhibition/induction profile of Huperzine A

Keywords: تعاملات دارویی; Huperzine A; Metabolic pathway; CYP inhibition; CYP induction; Drug interaction;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Effect of Red Ginseng on cytochrome P450 and P-glycoprotein activities in healthy volunteers

Keywords: تعاملات دارویی; cytochrome P450; drug interaction; P-glycoprotein; Red Ginseng;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Quantification of darunavir and etravirine in human peripheral blood mononuclear cells using high performance liquid chromatography tandem mass spectrometry (LC–MS/MS), clinical application in a cohort of 110 HIV-1 infected patients and evidence of a pote

Keywords: تعاملات دارویی; LC–MS/MS; Intracellular; Anti-retroviral drugs; HIV-1; Drug interaction; Darunavir; Etravirine; PBMCs

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Chloroquine and Hydroxychloroquine Are Novel Inhibitors of Human Organic Anion Transporting Polypeptide 1A2

Keywords: تعاملات دارویی; chloroquine; hydroxychloroquine; solute carrier transporters; organic anion transporters; organic anion-transporting polypeptide transporters; organic cation transporters; drug interaction; inhibition; OATP1A2; SLCs; solute carrier transporters; CQ; chlor

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling

Keywords: تعاملات دارویی; clinical pharmacokinetics; CYP enzymes; drug interaction; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasm

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma and its application to pharmacokinetic study

Keywords: تعاملات دارویی; Methyphenidate; Ethylphenidate; Chiral separation; UFLC-MS/MS; Pharmacokinetics; Drug interaction

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Regular articleInhibitory and inductive effects of Phikud Navakot extract on human cytochrome P450

Keywords: تعاملات دارویی; Cytochrome P450; Drug interaction; Induction; Inhibition; Phikud Navakot;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Evaluation of the In Vitro Efficacy of Sevelamer Hydrochloride and Sevelamer Carbonate

Keywords: تعاملات دارویی; sevelamer; inductively coupled plasma; phosphate binding; langmuir equation; bioequivalence; polymeric drugs; kinetics; absorption; drug interaction;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Évaluation à un an de l'information reçue par les patients ambulatoires sur l'interaction rilpivirine-modificateurs du pH gastrique

Keywords: تعاملات دارویی; Anti-acide; Anti-sécrétoire; Évaluation; Interaction médicamenteuse; Nourriture; Rilpivirine; PH gastrique; VIH; Antacid; Antisecretory; Evaluation; Drug interaction; Food; Gastric pH; HIV; Rilpivirine;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

The mixture of Salvia miltiorrhiza–Carthamus tinctorius (Danhong injection) alleviates low-dose aspirin induced gastric mucosal damage in rats

Keywords: تعاملات دارویی; Danhong injection; Aspirin; Drug interaction; Cyclooxygenase; Drug combination; Gastric mucosal damageASA, aspirin; CAT, catalase; COX, cyclooxygenase; DCFH-DA, 2, 7-dichlorofuorescin diacetate; DHI, Danhong injection; DSS, danshensu; EIA, enzyme immunoas

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Les principales interactions médicamenteuses pharmacocinétiques

Keywords: تعاملات دارویی; absorption; distribution; élimination; interaction médicamenteuse; interaction pharmacocinétique; métabolisationabsorption; distribution; drug interaction; elimination; metabolization; pharmacokinetic interaction

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Glyceollin Effects on MRP2 and BCRP in Caco-2 Cells, and Implications for Metabolic and Transport Interactions

Keywords: تعاملات دارویی; active transport; drug interaction; efflux pumps; food effects; flavonoids; genistein; glyceollin; intestinal absorption; intestinal metabolism; phytoestrogen;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Gastrointestinal Behavior of Weakly Acidic BCS Class II Drugs in Man-Case Study of Diclofenac Potassium

Keywords: تعاملات دارویی; oral drug delivery; biopharmaceutics; clinical pharmacokinetics; gastrointestinal; supersaturation; precipitation; disposition; food effects; drug interaction; Biopharmaceutics Classification System (BCS);

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Simultaneous determination of amoxicillin and chloramphenicol and their drug interaction study by the validated UPLC method

Keywords: تعاملات دارویی; Antibiotic; UPLC method; Amoxicillin; Chloramphenicol; Drug interaction

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Pharmacokinetic-pharmacodynamic influence of N-palmitoylethanolamine, arachidonyl-2′-chloroethylamide and WIN 55,212-2 on the anticonvulsant activity of antiepileptic drugs against audiogenic seizures in DBA/2 mice

Keywords: تعاملات دارویی; PEA; Cannabinoid compounds; PPAR-α receptors; Audiogenic seizure model; Antiepileptic drugs; Drug interaction;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Lotus leaf alkaloid fraction can strongly inhibit CYP2D6 isoenzyme activity

Keywords: تعاملات دارویی; Lotus; Nelumbo nucifera; Alkaloid; CYP2D6; Drug interaction;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2016 سفارش ترجمه

Simultaneous determination of telmisartan and pitavastatin in rat plasma by UPLC-MS/MS: Application to pharmacokinetic interaction study

Keywords: تعاملات دارویی; Telmisartan; Pitavastatin; LC-MS/MS; Pharmacokinetics; Drug interaction;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

Pharmacological interaction between LABAs and LAMAs in the airways: optimizing synergy

Keywords: تعاملات دارویی; LABA; LAMA; COPD; Drug interaction; Dual bronchodilation; Translation research; Airways smooth muscle; Clinical trials;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Study of pharmacokinetic interaction of paroxetine and roxithromycin on bencycloquidium bromide in healthy subjects

Keywords: تعاملات دارویی; Bencycloquidium bromide; Drug interaction; Pharmacokinetics; Paroxetine; Roxithromycin

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Liver-selective distribution in rats supports the importance of active uptake into the liver via organic anion transporting polypeptides (OATPs) in humans

Keywords: تعاملات دارویی; Organic anion transporting polypeptide; Drug interaction; Hepatic uptake; Tissue distribution; Regulatory science

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Mécanismes des interactions pharmacocinétiques impliquant les agents anticancéreux oraux

Keywords: تعاملات دارویی; Agents anticancéreux oraux; Interaction médicamenteuses; Pharmacocinétique; Oral anticancer agents; Drug interaction; Pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Development of an LC–MS/MS method for simultaneous determination of memantine and donepezil in rat plasma and its application to pharmacokinetic study

Keywords: تعاملات دارویی; Memantine; Donepezil; Alzheimer’s disease; LC–MS/MS; Pharmacokinetics; Drug interaction

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The effects of drugs with immunosuppressive or immunomodulatory activities on xenobiotics-metabolizing enzymes expression in primary human hepatocytes

Keywords: تعاملات دارویی; Transplant drugs; Cytochrome P450; Human hepatocytes; Drug interaction; Xenoreceptors;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Effects of Fostamatinib on the Pharmacokinetics of Digoxin (a P-Glycoprotein Substrate): Results From in Vitro and Phase I Clinical Studies

Keywords: تعاملات دارویی; digoxin; drug interaction; fostamatinib; pharmacokinetic parameters; rheumatoid arthritis;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction

Keywords: تعاملات دارویی; CYP2B6; Metabolism based inhibition; Selegiline; Drug interaction; Static model

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Original ResearchEvaluation of the Potential for Pharmacokinetic Drug-Drug Interaction Between Armodafinil and Carbamazepine in Healthy Adults

Keywords: تعاملات دارویی; armodafinil; carbamazepine; carbamazepine-10; 11-epoxide; drug interaction;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Synergistic interaction between tapentadol and flupirtine in the rat orafacial formalin test

Keywords: تعاملات دارویی; Tapentadol; Flupirtine; Pharmacodynamics; Orofacial formalin test; Rat; Drug interaction;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2015 سفارش ترجمه

Drug–laboratory interaction between beta-lactam antibiotics and the galactomannan antigen test used to detect mould infections

Keywords: تعاملات دارویی; Piperacillin–tazobactam; Galactomannan; Beta-lactams; Drug interaction

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

Interaction pristinamycine/antivitamine K : analyse de la base française de pharmacovigilance

Keywords: تعاملات دارویی; pristinamycine; antivitamine K; interaction; pharmacovigilance; hémorragies; pristinamycin; vitamin K antagonist; drug interaction; pharmacovigilance; haemorrhage; Afssaps; Agence française de sécurité sanitaire des produits de santé; AMM; autorisati

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه